AC T00345
XX
ID T00345
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DT 20.10.1992 (created); ewi.
DT 08.02.2006 (updated); vma.
CO Copyright (C), QIAGEN.
XX
FA H
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SY H; Hairy.
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OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
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GE G018871 h.
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CL C0010; bHLH.
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SZ 337 AA; 37.0 kDa (cDNA) (calc.).
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SQ MVTGVTAANMTNVLGTAVVPAQLKETPLKSDRRSNKPIMEKRRRARINNCLNELKTLILD
SQ ATKKDPARHSKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSR
SQ FPGIEPAQRRRLLQHLSNCINGVKTELHQQQRQQQQQSIHAQMLPSPPSSPEQDSQQGAA
SQ APYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAV
SQ AAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPSSPANSSYE
SQ PMDIKPSVIQRVPMEQQPLSLVIKKQIKEEEQPWRPW
XX
SC Swiss-Prot#P14003
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FT 32 89 
PF00010; Helix-loop-helix DNA-binding domain.
FT 32 89 
PS50888; HLH.
FT 37 94 
SM00353; finulus.
FT 105 145 
PF07527; Hairy Orange.
FT 105 145 
SM00511; ORANGE.
FT 107 136 
PS51054; ORANGE.
XX
SF WRPW peptide is essential for Hairy activity [8];
SF WRPW motif is required for interaction with Groucho protein that mediates maternal influences on neurogenesis, segmentation and sex determination [4];
SF may bind specifically to non-canonical sequences [3];
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FF transcriptional repressor [2];
FF pair-rule gene product, involved in embryonic segmentation and adult bristle patterning [2] [3] [8] [1];
FF repression of Ac by H is essential for peripheral nervous system development [2];
FF hairy gene is regulated by dorsal and bicoid (maternal effect genes) [6];
FF expressed in 7 regularly spaced stripe along the anterior-posterior egg axis plus 12-15 nuclei in region 0 (95-85% egg length) [6];
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IN T02451 groucho; fruit fly, Drosophila melanogaster.
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MX M00067 I$HAIRY_01.
MX M03145 I$H_01.
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BS R04159.
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DR TRANSPATH: MO000024866.
DR EMBL: X15904;
DR EMBL: X15905;
DR UniProtKB: P14003;
DR FLYBASE: FBgn0001168; h.
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RN [1]; RE0000472.
RX PUBMED: 2479541.
RA Rushlow C. A., Hogan A., Pinchin M. A., Howe K. M., Lardelli M., Ish-Horowicz D.
RT The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc
RL EMBO J. 8:3095-3103 (1989).
RN [2]; RE0002933.
RX PUBMED: 7958929.
RA van Doren M., Bailey A. M., Esnayra J., Ede K., Posakony J. W.
RT Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete
RL Genes Dev. 8:2729-2742 (1994).
RN [3]; RE0002934.
RX PUBMED: 7958930.
RA Ohsako S., Hyer J., Panganiban G., Oliver I., Caudy M.
RT hairy function as a DNA-binding helix--loop--helix repressor of Drosophila sensory organ formation
RL Genes Dev. 8:2743-2755 (1994).
RN [4]; RE0003668.
RX PUBMED: 8001118.
RA Paroush Z., Finley jr R. L., Kidd T., Wainwright S. M., Ingham P. W., Brent R., Ish-Horowicz D.
RT Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
RL Cell 79:805-815 (1994).
RN [5]; RE0003669.
RX PUBMED: 6776413.
RA Nuesslein-Volhard C., Wieschaus E.
RT Mutations affecting segment number and polarity in Drosophila
RL Nature 287:795-801 (1980).
RN [6]; RE0003670.
RA Ingham P. W., Howard K. R., Ish-Horowicz D.
RT Transcription pattern of the Drosophila segmentation gene hairy
RL Nature 318:439-445 (1985).
RN [7]; RE0003671.
RX PUBMED: 3006986.
RA Ish-Horowicz D., Howard K. R., Pinchin S. M., Ingham P. W.
RT Molecular and genetic analysis of the hairy locus in Drosophila
RL Cold Spring Harb. Symp. Quant. Biol. 50:135-144 (1985).
RN [8]; RE0003672.
RX PUBMED: 1588951.
RA Wainwright S. M., Ish-Horowicz D.
RT Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains
RL Mol. Cell. Biol. 12:2475-2483 (1992).
XX
//