TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00378 XX ID T00378 XX DT 15.10.1992 (created); ewi. DT 24.04.2015 (updated); asv. CO Copyright (C), QIAGEN. XX FA HOXA3 XX SY homeo box A3; Hox-1.5; Hoxa-3; HOXA3; Mo-10. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G000527 Hoxa3. XX HO Pb (Drosophila). XX CL C0006; homeo; XX SF differential binding specificity in comparison with Msx-1 or En-1 is defined by nucleotides 3'-flanking to the TAAT core of the recognition sequence due to kinetic reasons [2]; SF the homeo domain of HOXA3 differs from HOXD3 and HOXB3 only in one amino acid residue [7]; XX CP aortic trunk, kidney, lung, pharynx, spinal cord, spinal ganglia, spleen, stomach, thyroid [4]. XX FF required for development of thymus and parathyroid and for full development of thyroid and submaxillary tissue [4]; FF mutants have defects in heart and arteries and reveal craniofacial abnormalities, similar to human DiGeorge's syndrome [4]; FF also expressed in certain kidney substructures [8]; FF subject to autoregulation [1]; XX IN T08441 Sox-10; rat, Rattus norvegicus. XX MX M00395 V$HOXA3_01. MX M01337 V$HOXA3_02. MX M02869 V$HOXA3_07. XX BS R00723. BS R67375. XX DR TRANSPATH: MO000046025. DR UniProtKB: P02831; HXA3_MOUSE. XX RN [1]; RE0002306. RX PUBMED: 2879282. RA Fainsod A., Bogarad L. D., Ruusala T., Lubin M., Crothers D. M., Ruddle F. H. RT The homeo domain of a murine protein binds 5' to its own homeo box RL Proc. Natl. Acad. Sci. USA 83:9532-9536 (1986). RN [2]; RE0003871. RX PUBMED: 8096059. RA Catron K. M., Iller N., Abate C. RT Nucleotides flanking a conserved TAAT core dictate the DNA binding specifity of three murine homeodomain proteins RL Mol. Cell. Biol. 13:2354-2365 (1993). RN [3]; RE0003872. RX PUBMED: 6091896. RA McGinnis W., Hart C. P., Gehring W. J., Ruddle F. H. RT Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila RL Cell 38:675-680 (1984). RN [4]; RE0003873. RX PUBMED: 1673020. RA Chisaka O., Capecchi M. R. RT Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5 RL Nature 350:473-479 (1991). RN [5]; RE0006757. RX PUBMED: 2904354. RA Gaunt S. J. RT Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5 RL Development 103:135-144 (1988). RN [6]; RE0006758. RX PUBMED: 2452725. RA Gaunt S. J. RT Homoeobox gene Hox-1.5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation RL Development 101:51-60 (1987). RN [7]; RE0013202. RX PUBMED: 8710855. RA Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M. RT Sequence and expression of the murine Hoxd-3 homeobox gene RL Proc. Natl. Acad. Sci. USA 93:8247-8252 (1996). RN [8]; RE0014517. RA Davies J. A., Brandli A. W. RT The Kidney Development Database; URL: RL Internet : (1997). RN [9]; RE0048308. RX PUBMED: 16582099. RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M. RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. RL Nucleic Acids Res. 34:1735-1744 (2006). XX //