AC T00378
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ID T00378
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DT 15.10.1992 (created); ewi.
DT 24.04.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA HOXA3
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SY homeo box A3; Hox-1.5; Hoxa-3; HOXA3; Mo-10.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000527 Hoxa3.
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HO Pb (Drosophila).
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CL C0006; homeo; 3.1.1.3.1.
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SF differential binding specificity in comparison with Msx-1 or En-1 is defined by nucleotides 3'-flanking to the TAAT core of the recognition sequence due to kinetic reasons [2];
SF the homeo domain of HOXA3 differs from HOXD3 and HOXB3 only in one amino acid residue [7];
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CP aortic trunk, kidney, lung, pharynx, spinal cord, spinal ganglia, spleen, stomach, thyroid [4].
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FF required for development of thymus and parathyroid and for full development of thyroid and submaxillary tissue [4];
FF mutants have defects in heart and arteries and reveal craniofacial abnormalities, similar to human DiGeorge's syndrome [4];
FF also expressed in certain kidney substructures [8];
FF subject to autoregulation [1];
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IN T08441 Sox-10; rat, Rattus norvegicus.
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MX M00395 V$HOXA3_01.
MX M01337 V$HOXA3_02.
MX M02869 V$HOXA3_07.
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BS R00723.
BS R67375.
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DR TRANSPATH: MO000046025.
DR UniProtKB: P02831; HXA3_MOUSE.
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RN [1]; RE0002306.
RX PUBMED: 2879282.
RA Fainsod A., Bogarad L. D., Ruusala T., Lubin M., Crothers D. M., Ruddle F. H.
RT The homeo domain of a murine protein binds 5' to its own homeo box
RL Proc. Natl. Acad. Sci. USA 83:9532-9536 (1986).
RN [2]; RE0003871.
RX PUBMED: 8096059.
RA Catron K. M., Iller N., Abate C.
RT Nucleotides flanking a conserved TAAT core dictate the DNA binding specifity of three murine homeodomain proteins
RL Mol. Cell. Biol. 13:2354-2365 (1993).
RN [3]; RE0003872.
RX PUBMED: 6091896.
RA McGinnis W., Hart C. P., Gehring W. J., Ruddle F. H.
RT Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila
RL Cell 38:675-680 (1984).
RN [4]; RE0003873.
RX PUBMED: 1673020.
RA Chisaka O., Capecchi M. R.
RT Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5
RL Nature 350:473-479 (1991).
RN [5]; RE0006757.
RX PUBMED: 2904354.
RA Gaunt S. J.
RT Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5
RL Development 103:135-144 (1988).
RN [6]; RE0006758.
RX PUBMED: 2452725.
RA Gaunt S. J.
RT Homoeobox gene Hox-1.5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation
RL Development 101:51-60 (1987).
RN [7]; RE0013202.
RX PUBMED: 8710855.
RA Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
RT Sequence and expression of the murine Hoxd-3 homeobox gene
RL Proc. Natl. Acad. Sci. USA 93:8247-8252 (1996).
RN [8]; RE0014517.
RA Davies J. A., Brandli A. W.
RT The Kidney Development Database; URL: http://www.ana.ed.ac.uk/anatomy/database/kidbase/tranfack.html
RL Internet : (1997).
RN [9]; RE0048308.
RX PUBMED: 16582099.
RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
RL Nucleic Acids Res. 34:1735-1744 (2006).
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