AC T00386
XX
ID T00386
XX
DT 15.10.1992 (created); ewi.
DT 29.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA HSTF
XX
SY dHSF (Drosophila heat shock factor); HAP; heat shock transcription factor; HSF; HSTF.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G123167 Hsf.
XX
SZ 691 AA; 76.9 kDa (cDNA) (calc.).
XX
SQ MSRSRSSAKAVQFKHESEEEEEDEEEQLPSRRMHSYGDAAAIGSGVPAFLAKLWRLVDDA
SQ DTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFHKITSIDNGGL
SQ RFDRDEIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTDVKVMRGRQ
SQ DNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQ
SQ LMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSP
SQ PAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHD
SQ VYTVTEAPDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILD
SQ AGDILVDSSSPKAQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPANDLYSVNFIS
SQ EDMPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFDVPTNSTLLDANQASTS
SQ KAAAKAQASEEEGMAVAKYSGAENGNNRDTNNSQLLRMASVDELHGHLESMQDELETLKD
SQ LLRGDGVAIDQNMLMGLFNDSDLMDNYGLSFPNDSISSEKKAPSGSELISYQPMYDLSDI
SQ LDTDDGNNDQEASRRQMQTQSSVLNTPRHEL
XX
SC Swiss-Prot#P22813
XX
FT 33 163 
winged helix homology (weak) [10].
FT 45 148 
SM00415; HSF.
FT 46 150 
DNA binding Domain [11].
FT 47 241 
PF00447; HSF-type DNA-binding.
FT 49 116 
PS50140; HSF_ETS.
FT 289 618 
PF00478; IMP dehydrogenase / GMP reductase domain.
XX
SF asymmetric molecular shape of the monomer, even higher asymmetry found for the trimer [9];
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FF cooperative DNA-binding to multiple elements (HSE) after trimerization [8] [9] [5];
FF inducing signals cause a transition from the inactive monomeric to the active trimeric state [9];
XX
IN T01264 HST; yeast, Kluyveromyces lactis.
XX
MX M00028 I$HSF_01.
MX M00163 I$HSF_02.
MX M00164 I$HSF_03.
MX M00165 I$HSF_04.
MX M00166 I$HSF_05.
MX M07852 I$HSF_06.
MX M07853 I$HSF_07.
MX M07854 I$HSF_08.
MX M07855 I$HSF_09.
XX
BS R00751.
BS R00752.
BS R00753.
BS R00754.
BS R00755.
BS R00756.
BS R00773.
BS R17395.
BS R00762.
BS R00775.
BS R00776.
XX
DR TRANSPATH: MO000045953.
DR EMBL: M60070; DMHSPHEX.
DR UniProtKB: P22813; HSF_DROME.
DR FLYBASE: FBgn0001222.
DR PDB: 1hks.
DR PDB: 1hkt.
XX
RN [1]; RE0000081.
RX PUBMED: 4028160.
RA Topol J., Ruden D. M., Parker C. S.
RT Sequences required for in vitro transcriptional activation of a Drosophila hsp 70 gene
RL Cell 42:527-537 (1985).
RN [2]; RE0000082.
RX PUBMED: 3100052.
RA Wiederrecht G., Shuey D. J., Kibbe W. A., Parker C. S.
RT The Saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties
RL Cell 48:507-515 (1987).
RN [3]; RE0000154.
RX PUBMED: 2590940.
RA Perisic O., Xiao H., Lis J. T.
RT Stable Binding of Drosophila Heat Shock Factor to Head-to-Head and Tail-to-Tail Repeats of a Conserved 5 bp Recognition Unit
RL Cell 59:797-806 (1989).
RN [4]; RE0000209.
RX PUBMED: 1899357.
RA Xiao H., Perisic O., Lis J. T.
RT Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit
RL Cell 64:585-593 (1991).
RN [5]; RE0000850.
RX PUBMED: 3711119.
RA Shuey D. J., Parker C. S.
RT Binding of Drosophila Heat-Shock Gene Transcription Factor to the hsp 70 Promoter
RL J. Biol. Chem. 261:7934-7940 (1986).
RN [6]; RE0001702.
RX PUBMED: 8423799.
RA Gallo G. J., Prentice H., Kingston R. E.
RT Heat shock factor is required for growth at normal temperatures in the fission yeast Schizosaccharomyces pombe
RL Mol. Cell. Biol. 13:749-761 (1993).
RN [7]; RE0001792.
RX PUBMED: 6325944.
RA Wu C.
RT Two protein-binding sites in chromatin implicated in the activation of heat-shock genes
RL Nature 309:229-234 (1984).
RN [8]; RE0005280.
RX PUBMED: 8421783.
RA Rabindran S. K., Haroun R. I., Clos J., Wisniewski J., Wu C.
RT Regulation of heat shock factor trimer formation: role of a conserved leucine zipper
RL Science 259:230-234 (1993).
RN [9]; RE0005284.
RX PUBMED: 8497263.
RA Westwood J. T., Wu C.
RT Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition
RL Mol. Cell. Biol. 13:3481-3486 (1993).
RN [10]; RE0006687.
RX PUBMED: 8286326.
RA Vuister G. W., Kim S.-J., Wu C., Bax A.
RT NMR Evidence for Similarities between the DNA-Binding Regions of Drosophila melanogaster Heat Shock Factor AND Helix-Turn-Helix and HNF-3/forkhead Families of Transcription Factors
RL Biochemistry 33:10-16 (1994).
RN [11]; RE0006688.
RX PUBMED: 7634100.
RA Vuister G. W., Kim S.-J., Orosz A., Marquardt J., Wu C., Bax A.
RT Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor
RL Nat. Struct. Biol. 1:605-614 (1994).
XX
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