AC T01264
XX
ID T01264
XX
DT 18.10.1994 (created); ewi.
DT 20.02.1997 (updated); ewi.
CO Copyright (C), QIAGEN.
XX
FA HST
XX
SY heat shock transcription factor; HSF; HST; HSTF.
XX
OS yeast, Kluyveromyces lactis
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
XX
CL C0050; HSF; F3.4.1.0.8.
XX
SZ 677 AA; 75.4 kDa (gene) (calc.).
XX
SQ MGHNDSVETMDEISNPNNILLPHDGTGLDATGISGSQEPYGMVDVLNPDSLKDDSNVDEP
SQ LIEDIVNPSLDPEGVVSAEPSNEVGTPLLQQPISLDHVITRPASAGGVYSIGNSSTSSAA
SQ KLSDGDLTNATDPLLNNAHGHGQPSSESQSHSNGYHKQGQSQQPLLSLNKRKLLAKAHVD
SQ KHHSKKKLSTTRARPAFVNKLWSMVNDKSNEKFIHWSTSGESIVVPNRERFVQEVLPKYF
SQ KHSNFASFVRQLNMYGWHKVQDVKSGSMLSNNDSRWEFENENFKRGKEYLLENIVRQKSN
SQ TNILGGTTNAEVDIHILLNELETVKYNQLAIAEDLKRITKDNEMLWKENMMARERHQSQQ
SQ QVLEKLLRFLSSVFGPNSAKTIGNGFQPDLIHELSDMQVNHMSNNNHNNTGNINPNAYHN
SQ ETDDPMANVFGPLTPTDQGKVPLQDYKLRPRLLLKNRSMSSSSSSNLNQRQSPQNRIVGQ
SQ SPPPQQQQQQQQQQGQPQGQQFSYPIQGGNQMMNQLGSPIGTQVGSPVGSQYGNQYGNQY
SQ SNQFGNQLQQQTSRPALHHGSNGEIRELTPSIVSSDSPDPAFFQDLQNNIDKQEESIQEI
SQ QDWITKLNPGPGEDGNTPIFPELNMPSYFANTGGSGQSEQPSDYGDSQIEELRNSRLHEP
SQ DRSFEEKNNGQKRRRAA
XX
SC Swiss-Prot#P22121
XX
FT 193 297 
SM00415; HSF.
FT 195 394 
PF00447; HSF-type DNA-binding.
FT 197 264 
PS50140; HSF_ETS.
FT 274 643 
PF00478; IMP dehydrogenase / GMP reductase domain.
XX
SF DNA-binding domain (DBD) forms a three-helix-bundle, capped by a four-stranded antiparallel beta-sheet, this forming a variant of the helix-turn-helix motif [2];
SF Pro-237 causes a kink within helix 2, therefore the angle between helices 2 and 3 is slightly smaller than usual in the helix-turn-helix motif, but the relative orientation of both helices is conserved [2];
SF most likely, helix 3 serves as recognition helix [2];
XX
FF mediates expression of heat-shock genes in response to elevated temperatures;
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IN T01042 HSF1-L; human, Homo sapiens.
IN T00384 HSF1; mouse, Mus musculus.
IN T00385 Hsf1p; yeast, Saccharomyces cerevisiae.
IN T01041 HSF; clawed frog, Xenopus laevis.
IN T01244 hsf; fission yeast, Schizosaccharomyces pombe.
IN T00386 HSTF; fruit fly, Drosophila melanogaster.
XX
DR EMBL: X55149; KLHSFG.
DR UniProtKB: P22121; HSF_KLULA.
XX
RN [1]; RE0000550.
RX PUBMED: 8262043.
RA Chen Y., Barlev N. A., Westergaard O., Jakobson B. K.
RT Identification of the C-terminal activator domain in yeast heat shock factor: independent control of transient and sustained transciptional activity
RL EMBO J. 12:5007-5018 (1993).
RN [2]; RE0005288.
RX PUBMED: 8284672.
RA Harrison C. J., Bohm A. A., Nelson H. C. M.
RT Crystal structure of the DNA binding domain of the heat shock transcription factor
RL Science 263:224-227 (1994).
RN [3]; RE0005289.
RX PUBMED: 1899375.
RA Jakobsen B. K., Pelham H. R. B.
RT A conserved heptapeptide restrains the activity of the yeast heat shock transcription factor
RL EMBO J. 10:369-375 (1991).
XX
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