TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00384 XX ID T00384 XX DT 26.01.1993 (created); hse. DT 20.02.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA HSF1 XX SY heat shock (transcription) factor 1; heat shock transcription factor 1; HSF; HSF-1; HTF; mHSF1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G009138 Hsf1. XX CL C0050; HSF; XX SF two isoforms, T01525 and T05813; SF HSF1 T00384 and HSF2 T00972 show differences in trimer cooperativity [9]; XX CP (C2C12). XX FF does not bind prior to or after recovery from heat shock; FF induced to DNA-binding by heat (within minutes) or other stress factors [10]; FF induced to DNA-binding by hypoxia [4] [8]; FF induced to DNA-binding by metabolic inhibition by rotenone or ATP depletion (K+/nigericin) [4]; FF induced to DNA-binding by prostaglandins [11] [12]; FF activation depends on Ca2+ ions and on a phosphorylation step [7] [10]; FF mediates heat shock responses, induced by following stress factors: heat, hydrogen peroxide, osmotic stress [14]; FF induced by following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor) [17]; FF important for constitutive expression of Hsp25, Hsp70, alphaB-Crystallin, but not for Hsp60 and Hsp90 [15]; FF disruption (knock out mouse) lowers the ratio of GSH:GSSG in heart homogenates [15]; FF HSF1 deficiency decreases G6PD activity [15]; FF absence of HSF1 increases oxidative stress and protein oxidative damages [15]; FF HSF1 deficiency decreases functional activity of cardiac ANT1 (adenine nucleotide translocase 1) [15]; FF aa C35 and C105 are essential for trimerization and activation of HSF1 (Note: positions differ from T01525 and T05813, C35=C36, C105=C103) [16]; FF coactivated with HSF2 T00972 by the following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor) [17]; FF heat shock causes nuclear localization, also increased nuclear localization during stress induced by cadmium and azetidine [17]; FF homozygous HSF1(--/--) mice (= HSF1 null mice, HSF1 deficient mice) exhibit prenatal lethality [18]; FF HSF1 is required for development of chorioallantoic placenta [18]; FF HSF1(--/--) mice exhibited postnatal growth retardation [18]; FF disruption of HSF1 eliminates the heat shock response in adult HSF1(--/--) mice and also increases mortality and exaggerates TNFalpha production during endotoxemia [18]; FF laboratory mice bearing inactivation of HSF1 expression exhibited increased mortality during pathological stimuli mimicking lethal inflammatory stimuli in humans [18]; FF interacts with HSBP1 and Hsp70 [19]; FF the HSF1 loop (encompassing aa 83-98) is critical for the DNA-binding specificity [20]; FF the HSF1 loop is required for heat inducible Hsp70 expression and protection from heat-induced apoptosis (MEF cells) [20]; XX IN T06285 HSBP1; mouse, Mus musculus. IN T01264 HST; yeast, Kluyveromyces lactis. XX MX M00146 V$HSF1_01. MX M07259 V$HSF1_Q5. MX M07459 V$HSF1_Q5_01. MX M01023 V$HSF1_Q6. MX M02017 V$HSF1_Q6_01. MX M00641 V$HSF_Q6. XX BS R15970. BS R15971. BS R15972. BS R15973. BS R15974. BS R15975. BS R15976. BS R15977. BS R15978. BS R15979. BS R15980. BS R15981. BS R15982. BS R15983. BS R15984. BS R15985. BS R15986. BS R15987. BS R15988. BS R15989. BS R15990. BS R15991. BS R15992. BS R15993. BS R15994. BS R15995. BS R15996. BS R15997. BS R15998. BS R15999. BS R16000. BS R16001. BS R16002. BS R16003. BS R16004. BS R16005. BS R16006. BS R16007. BS R16008. BS R16009. BS R16010. BS R01773. BS R01925. BS R03465. BS R00762. BS R00763. BS R00764. BS R40028. BS R02181. BS R73518. BS R71489. BS R71486. BS R41534. BS R41318. BS R59743. BS R59749. BS R03464. BS R40532. BS R72594. BS R72596. BS R65577. BS R66373. BS R71492. BS R71493. BS R15740. BS R65821. BS R65575. XX DR TRANSPATH: MO000043615. DR UniProtKB: P38532; XX RN [1]; RE0000170. RX PUBMED: 2018972. RA Sorger P. K. RT Heat shock factor and the heat shock response RL Cell 65:363-366 (1991). RN [2]; RE0000766. RX PUBMED: 1717345. RA Sarge K. D., Zimarino V., Holm K., Wu C., Morimoto R. I. RT Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability RL Genes Dev. 5:1902-1911 (1991). RN [3]; RE0000851. RX PUBMED: 3198647. RA Goldenberg C. J., Luo Y., Fenna M., Baler R., Weinmann R., Voellmy R. RT Purified Human Factor Activates Heat Shock Promoter in a HeLa Cell-free Transcription System RL J. Biol. Chem. 263:19734-19739 (1988). RN [4]; RE0001121. RX PUBMED: 1569208. RA Benjamin I. J., Horie S., Greenberg M. L., Alpern R. J., Williams R. S. RT Induction of stress proteins in cultured myogenic cells RL J. Clin. Invest. 89:1685-1689 (1992). RN [5]; RE0001575. RX PUBMED: 1986252. RA Abravaya K., Phillips B., Morimoto R. I. RT Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting RL Mol. Cell. Biol. 11:586-592 (1991). RN [6]; RE0001657. RX PUBMED: 1904540. RA Cunniff N. F. A., Wagner J., Morgan W. D. RT Modular recognition of 5-base-pair DNA sequence motifs by human heat shock transcription factor RL Mol. Cell. Biol. 11:3504-3514 (1991). RN [7]; RE0001693. RX PUBMED: 2038338. RA Price B. D., Calderwood S. K. RT Ca2+ is essential for multistep activation of the heat shock factor in permeabilized RL Mol. Cell. Biol. 11:3365-3368 (1991). RN [8]; RE0002440. RX PUBMED: 1696723. RA Benjamin I. J., Kroeger B., Williams R. S. RT Activation of the heat shock transcription factor by hypoxia in mammalian cells RL Proc. Natl. Acad. Sci. USA 87:6263-6267 (1990). RN [9]; RE0003118. RX PUBMED: 7935474. RA Kroeger P. E., Morimoto R. I. RT Selection of new HSF1 and HSF2 DNA-binding sites reveals differences in trimer cooperativity RL Mol. Cell. Biol. 14:7592-7603 (1994). RN [10]; RE0005277. RX PUBMED: 8441385. RA Sarge K. D., Murphy S. P., Morimoto R. I. RT Activation of heat shock gene transcription by heat shockfactor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress RL Mol. Cell. Biol. 13:1392-1407 (1993). RN [11]; RE0005279. RX PUBMED: 1631114. RA Amici C., Sistonen L., Santoro M. G., Morimoto R. I. RT Antiproliferative prostaglandins activate heat shock transcription factor RL Proc. Natl. Acad. Sci. USA 89:6227-6231 (1992). RN [12]; RE0005281. RX PUBMED: 8328983. RA Koizumi T., Negishi M., Ichikawa A. RT Activation of heat shock transcription factors by delta12-prostaglandin J2 and its inhibition by intracellular glutathione RL Biochem. Pharmacol. 45:2457-2464 (1993). RN [13]; RE0023684. RA Morimoto R., Jurivich D., Kroeger P., Mathur S., Murphy S., Nakai A., Sarge K., Abravaya K., Sistonen L. RT Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors RL The Biology of Heat Shock Proteins and Molecular Chaperones :417-455 (1994). RN [14]; RE0023693. RX PUBMED: 10547058. RA Nakai A. RT New aspects in the vertebrate heat shock factor system: Hsf3 and Hsf4. RL Cell Stress Chaperones 4:86-93 (1999). RN [15]; RE0024937. RX PUBMED: 12356732. RA Yan L. J., Christians E. S., Liu L., Xiao X., Sohal R. S., Benjamin I. J. RT Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. RL EMBO J. 21:5164-5172 (2002). RN [16]; RE0024951. RX PUBMED: 12600944. RA Ahn S. G., Thiele D. J. RT Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. RL Genes Dev. 17:516-528 (2003). RN [17]; RE0024962. RX PUBMED: 11585899. RA Mathew A., Mathur S. K., Jolly C., Fox S. G., Kim S., Morimoto R. I. RT Stress-specific activation and repression of heat shock factors 1 and 2. RL Mol. Cell. Biol. 21:7163-7171 (2001). RN [18]; RE0024965. RX PUBMED: 10545106. RA Xiao X., Zuo X., Davis A. A., McMillan D. R., Curry B. B., Richardson J. A., Benjamin I. J. RT HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. RL EMBO J. 18:5943-5952 (1999). RN [19]; RE0024993. RX PUBMED: 9649501. RA Satyal S. H., Chen D., Fox S. G., Kramer J. M., Morimoto R. I. RT Negative regulation of the heat shock transcriptional response by HSBP1. RL Genes Dev. 12:1962-1974 (1998). RN [20]; RE0025007. RX PUBMED: 11511544. RA Ahn S. G., Liu P. C., Klyachko K., Morimoto R. I., Thiele D. J. RT The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress. RL Genes Dev. 15:2134-2145 (2001). XX //