AC T00384
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ID T00384
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DT 26.01.1993 (created); hse.
DT 20.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA HSF1
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SY heat shock (transcription) factor 1; heat shock transcription factor 1; HSF; HSF-1; HTF; mHSF1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009138 Hsf1.
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CL C0050; HSF; 3.4.1.0.1.
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SF two isoforms, T01525 and T05813;
SF HSF1 T00384 and HSF2 T00972 show differences in trimer cooperativity [9];
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CP (C2C12).
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FF does not bind prior to or after recovery from heat shock;
FF induced to DNA-binding by heat (within minutes) or other stress factors [10];
FF induced to DNA-binding by hypoxia [4] [8];
FF induced to DNA-binding by metabolic inhibition by rotenone or ATP depletion (K+/nigericin) [4];
FF induced to DNA-binding by prostaglandins [11] [12];
FF activation depends on Ca2+ ions and on a phosphorylation step [7] [10];
FF mediates heat shock responses, induced by following stress factors: heat, hydrogen peroxide, osmotic stress [14];
FF induced by following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor) [17];
FF important for constitutive expression of Hsp25, Hsp70, alphaB-Crystallin, but not for Hsp60 and Hsp90 [15];
FF disruption (knock out mouse) lowers the ratio of GSH:GSSG in heart homogenates [15];
FF HSF1 deficiency decreases G6PD activity [15];
FF absence of HSF1 increases oxidative stress and protein oxidative damages [15];
FF HSF1 deficiency decreases functional activity of cardiac ANT1 (adenine nucleotide translocase 1) [15];
FF aa C35 and C105 are essential for trimerization and activation of HSF1 (Note: positions differ from T01525 and T05813, C35=C36, C105=C103) [16];
FF coactivated with HSF2 T00972 by the following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor) [17];
FF heat shock causes nuclear localization, also increased nuclear localization during stress induced by cadmium and azetidine [17];
FF homozygous HSF1(--/--) mice (= HSF1 null mice, HSF1 deficient mice) exhibit prenatal lethality [18];
FF HSF1 is required for development of chorioallantoic placenta [18];
FF HSF1(--/--) mice exhibited postnatal growth retardation [18];
FF disruption of HSF1 eliminates the heat shock response in adult HSF1(--/--) mice and also increases mortality and exaggerates TNFalpha production during endotoxemia [18];
FF laboratory mice bearing inactivation of HSF1 expression exhibited increased mortality during pathological stimuli mimicking lethal inflammatory stimuli in humans [18];
FF interacts with HSBP1 and Hsp70 [19];
FF the HSF1 loop (encompassing aa 83-98) is critical for the DNA-binding specificity [20];
FF the HSF1 loop is required for heat inducible Hsp70 expression and protection from heat-induced apoptosis (MEF cells) [20];
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IN T06285 HSBP1; mouse, Mus musculus.
IN T01264 HST; yeast, Kluyveromyces lactis.
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MX M00146 V$HSF1_01.
MX M07259 V$HSF1_Q5.
MX M07459 V$HSF1_Q5_01.
MX M01023 V$HSF1_Q6.
MX M02017 V$HSF1_Q6_01.
MX M00641 V$HSF_Q6.
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BS R15970.
BS R15971.
BS R15972.
BS R15973.
BS R15974.
BS R15975.
BS R15976.
BS R15977.
BS R15978.
BS R15979.
BS R15980.
BS R15981.
BS R15982.
BS R15983.
BS R15984.
BS R15985.
BS R15986.
BS R15987.
BS R15988.
BS R15989.
BS R15990.
BS R15991.
BS R15992.
BS R15993.
BS R15994.
BS R15995.
BS R15996.
BS R15997.
BS R15998.
BS R15999.
BS R16000.
BS R16001.
BS R16002.
BS R16003.
BS R16004.
BS R16005.
BS R16006.
BS R16007.
BS R16008.
BS R16009.
BS R16010.
BS R01773.
BS R01925.
BS R03465.
BS R00762.
BS R00763.
BS R00764.
BS R40028.
BS R02181.
BS R73518.
BS R71489.
BS R71486.
BS R41534.
BS R41318.
BS R59743.
BS R59749.
BS R03464.
BS R40532.
BS R72594.
BS R72596.
BS R65577.
BS R66373.
BS R71492.
BS R71493.
BS R15740.
BS R65821.
BS R65575.
XX
DR TRANSPATH: MO000043615.
DR UniProtKB: P38532;
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RN [1]; RE0000170.
RX PUBMED: 2018972.
RA Sorger P. K.
RT Heat shock factor and the heat shock response
RL Cell 65:363-366 (1991).
RN [2]; RE0000766.
RX PUBMED: 1717345.
RA Sarge K. D., Zimarino V., Holm K., Wu C., Morimoto R. I.
RT Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability
RL Genes Dev. 5:1902-1911 (1991).
RN [3]; RE0000851.
RX PUBMED: 3198647.
RA Goldenberg C. J., Luo Y., Fenna M., Baler R., Weinmann R., Voellmy R.
RT Purified Human Factor Activates Heat Shock Promoter in a HeLa Cell-free Transcription System
RL J. Biol. Chem. 263:19734-19739 (1988).
RN [4]; RE0001121.
RX PUBMED: 1569208.
RA Benjamin I. J., Horie S., Greenberg M. L., Alpern R. J., Williams R. S.
RT Induction of stress proteins in cultured myogenic cells
RL J. Clin. Invest. 89:1685-1689 (1992).
RN [5]; RE0001575.
RX PUBMED: 1986252.
RA Abravaya K., Phillips B., Morimoto R. I.
RT Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting
RL Mol. Cell. Biol. 11:586-592 (1991).
RN [6]; RE0001657.
RX PUBMED: 1904540.
RA Cunniff N. F. A., Wagner J., Morgan W. D.
RT Modular recognition of 5-base-pair DNA sequence motifs by human heat shock transcription factor
RL Mol. Cell. Biol. 11:3504-3514 (1991).
RN [7]; RE0001693.
RX PUBMED: 2038338.
RA Price B. D., Calderwood S. K.
RT Ca2+ is essential for multistep activation of the heat shock factor in permeabilized
RL Mol. Cell. Biol. 11:3365-3368 (1991).
RN [8]; RE0002440.
RX PUBMED: 1696723.
RA Benjamin I. J., Kroeger B., Williams R. S.
RT Activation of the heat shock transcription factor by hypoxia in mammalian cells
RL Proc. Natl. Acad. Sci. USA 87:6263-6267 (1990).
RN [9]; RE0003118.
RX PUBMED: 7935474.
RA Kroeger P. E., Morimoto R. I.
RT Selection of new HSF1 and HSF2 DNA-binding sites reveals differences in trimer cooperativity
RL Mol. Cell. Biol. 14:7592-7603 (1994).
RN [10]; RE0005277.
RX PUBMED: 8441385.
RA Sarge K. D., Murphy S. P., Morimoto R. I.
RT Activation of heat shock gene transcription by heat shockfactor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress
RL Mol. Cell. Biol. 13:1392-1407 (1993).
RN [11]; RE0005279.
RX PUBMED: 1631114.
RA Amici C., Sistonen L., Santoro M. G., Morimoto R. I.
RT Antiproliferative prostaglandins activate heat shock transcription factor
RL Proc. Natl. Acad. Sci. USA 89:6227-6231 (1992).
RN [12]; RE0005281.
RX PUBMED: 8328983.
RA Koizumi T., Negishi M., Ichikawa A.
RT Activation of heat shock transcription factors by delta12-prostaglandin J2 and its inhibition by intracellular glutathione
RL Biochem. Pharmacol. 45:2457-2464 (1993).
RN [13]; RE0023684.
RA Morimoto R., Jurivich D., Kroeger P., Mathur S., Murphy S., Nakai A., Sarge K., Abravaya K., Sistonen L.
RT Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors
RL The Biology of Heat Shock Proteins and Molecular Chaperones :417-455 (1994).
RN [14]; RE0023693.
RX PUBMED: 10547058.
RA Nakai A.
RT New aspects in the vertebrate heat shock factor system: Hsf3 and Hsf4.
RL Cell Stress Chaperones 4:86-93 (1999).
RN [15]; RE0024937.
RX PUBMED: 12356732.
RA Yan L. J., Christians E. S., Liu L., Xiao X., Sohal R. S., Benjamin I. J.
RT Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage.
RL EMBO J. 21:5164-5172 (2002).
RN [16]; RE0024951.
RX PUBMED: 12600944.
RA Ahn S. G., Thiele D. J.
RT Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.
RL Genes Dev. 17:516-528 (2003).
RN [17]; RE0024962.
RX PUBMED: 11585899.
RA Mathew A., Mathur S. K., Jolly C., Fox S. G., Kim S., Morimoto R. I.
RT Stress-specific activation and repression of heat shock factors 1 and 2.
RL Mol. Cell. Biol. 21:7163-7171 (2001).
RN [18]; RE0024965.
RX PUBMED: 10545106.
RA Xiao X., Zuo X., Davis A. A., McMillan D. R., Curry B. B., Richardson J. A., Benjamin I. J.
RT HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice.
RL EMBO J. 18:5943-5952 (1999).
RN [19]; RE0024993.
RX PUBMED: 9649501.
RA Satyal S. H., Chen D., Fox S. G., Kramer J. M., Morimoto R. I.
RT Negative regulation of the heat shock transcriptional response by HSBP1.
RL Genes Dev. 12:1962-1974 (1998).
RN [20]; RE0025007.
RX PUBMED: 11511544.
RA Ahn S. G., Liu P. C., Klyachko K., Morimoto R. I., Thiele D. J.
RT The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress.
RL Genes Dev. 15:2134-2145 (2001).
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