TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00972 XX ID T00972 XX DT 28.09.1993 (created); ewi. DT 04.05.2011 (updated); lat. CO Copyright (C), QIAGEN. XX FA HSF2 XX SY heat shock factor 2; heat shock transcription factor 2; HSF-2; mHSF2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G010177 Hsf2. XX CL C0050; HSF; XX SF two alternate isoforms: HSF2alpha and HSF2beta [3]; SF HSF1 T00384 and HSF2 T00972 show differences in trimer cooperativity [2]; XX FF induced by following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor), hemin, cadmium [4]; FF coactivated with HSF1 T00384 by the following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor) [4]; FF relocalized from the cytoplasm and nucleus to a perinuclear region during heat shock, but not by other stressors (cadmium, azetidine) [4]; FF increased nuclear concentration of HSF2 during stress induced by cadmium and azetidine [4]; FF temperature-sensitive protein, becomes insoluble upon heat shock, but not by other stress factors (cadmium, azetidine) [4]; FF heat shock induced insolubility is reversible and coincident with a relocalization of HSF2 from the perinuclear region to a diffuse distribution throughout the cell [4]; FF acquisition of thermotolerance prevents inactivation of HSF2, during this process molecular chaperones may serve as positive regulators of HSF2 by maintaining it in a native state [4]; FF original paper on genomic structure [5]; FF heart and brain exhibit primarily the HSF2beta-mRNA, testes and isolated spermatogenic cell types exhibit primarily the HSF2alpha-mRNA [3]; FF the mRNAs of alpha and beta are identical except for a short nucleotide sequence, corresponding to 18 additional amino acids, found solely in alpha (additional exon) [3]; XX MX M00147 V$HSF2_01. MX M01244 V$HSF2_02. MX M07358 V$HSF2_Q6. XX BS R00764. BS R34149. BS R03464. XX DR TRANSPATH: MO000046037. DR UniProtKB: P38533; HSF2_MOUSE. XX RN [1]; RE0000766. RX PUBMED: 1717345. RA Sarge K. D., Zimarino V., Holm K., Wu C., Morimoto R. I. RT Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability RL Genes Dev. 5:1902-1911 (1991). RN [2]; RE0003118. RX PUBMED: 7935474. RA Kroeger P. E., Morimoto R. I. RT Selection of new HSF1 and HSF2 DNA-binding sites reveals differences in trimer cooperativity RL Mol. Cell. Biol. 14:7592-7603 (1994). RN [3]; RE0010691. RX PUBMED: 7565677. RA Goodson M. L., Park-Sarge O.-K., Sarge K. D. RT Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities RL Mol. Cell. Biol. 15:5288-5293 (1995). RN [4]; RE0024962. RX PUBMED: 11585899. RA Mathew A., Mathur S. K., Jolly C., Fox S. G., Kim S., Morimoto R. I. RT Stress-specific activation and repression of heat shock factors 1 and 2. RL Mol. Cell. Biol. 21:7163-7171 (2001). RN [5]; RE0024996. RX PUBMED: 10333528. RA Manuel M., Sage J., Mattei M. G., Morange M., Mezger V. RT Genomic structure and chromosomal localization of the mouse Hsf2 gene and promoter sequences. RL Gene 232:115-124 (1999). XX //