DT 28.09.1993 (created); ewi.
DT 04.05.2011 (updated); lat.
CO Copyright (C), QIAGEN.
SY heat shock factor 2; heat shock transcription factor 2; HSF-2; mHSF2.
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
GE G010177 Hsf2.
CL C0050; HSF; 220.127.116.11.2.
SF two alternate isoforms: HSF2alpha and HSF2beta ;
SF HSF1 T00384 and HSF2 T00972 show differences in trimer cooperativity ;
FF induced by following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor), hemin, cadmium ;
FF coactivated with HSF1 T00384 by the following stress factors: heat, azetidine (amino acid analogue), MG132 (proteasome inhibitor) ;
FF relocalized from the cytoplasm and nucleus to a perinuclear region during heat shock, but not by other stressors (cadmium, azetidine) ;
FF increased nuclear concentration of HSF2 during stress induced by cadmium and azetidine ;
FF temperature-sensitive protein, becomes insoluble upon heat shock, but not by other stress factors (cadmium, azetidine) ;
FF heat shock induced insolubility is reversible and coincident with a relocalization of HSF2 from the perinuclear region to a diffuse distribution throughout the cell ;
FF acquisition of thermotolerance prevents inactivation of HSF2, during this process molecular chaperones may serve as positive regulators of HSF2 by maintaining it in a native state ;
FF original paper on genomic structure ;
FF heart and brain exhibit primarily the HSF2beta-mRNA, testes and isolated spermatogenic cell types exhibit primarily the HSF2alpha-mRNA ;
FF the mRNAs of alpha and beta are identical except for a short nucleotide sequence, corresponding to 18 additional amino acids, found solely in alpha (additional exon) ;
MX M00147 V$HSF2_01.
MX M01244 V$HSF2_02.
MX M07358 V$HSF2_Q6.
DR TRANSPATH: MO000046037.
DR UniProtKB: P38533; HSF2_MOUSE.
RN ; RE0000766.
RX PUBMED: 1717345.
RA Sarge K. D., Zimarino V., Holm K., Wu C., Morimoto R. I.
RT Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability
RL Genes Dev. 5:1902-1911 (1991).
RN ; RE0003118.
RX PUBMED: 7935474.
RA Kroeger P. E., Morimoto R. I.
RT Selection of new HSF1 and HSF2 DNA-binding sites reveals differences in trimer cooperativity
RL Mol. Cell. Biol. 14:7592-7603 (1994).
RN ; RE0010691.
RX PUBMED: 7565677.
RA Goodson M. L., Park-Sarge O.-K., Sarge K. D.
RT Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities
RL Mol. Cell. Biol. 15:5288-5293 (1995).
RN ; RE0024962.
RX PUBMED: 11585899.
RA Mathew A., Mathur S. K., Jolly C., Fox S. G., Kim S., Morimoto R. I.
RT Stress-specific activation and repression of heat shock factors 1 and 2.
RL Mol. Cell. Biol. 21:7163-7171 (2001).
RN ; RE0024996.
RX PUBMED: 10333528.
RA Manuel M., Sage J., Mattei M. G., Morange M., Mezger V.
RT Genomic structure and chromosomal localization of the mouse Hsf2 gene and promoter sequences.
RL Gene 232:115-124 (1999).