TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00425 XX ID T00425 XX DT 15.03.1993 (created); ewi. DT 20.04.2015 (updated); jtr. CO Copyright (C), QIAGEN. XX FA IRF-2 XX SY INTERFERON REGULATORY FACTOR 2; IRF-2; IRF2; PRDI-BFc; PRDI-BFi. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001059 Irf2. XX CL C0022; trp; XX SF highly similar to IRF-2 (62% identity within the N-terminal part, 25% between the C-terminal sequences), but lacking the acidic region of IRF-1 [1]; SF IAD2 domain is conserved between IRF-1 and IRF-2, but is different in other family members [11]; SF IAD2 is responsible for protein-protein interactions [11]; XX CP RAWt264.7 [13]. XX FF Involved in the regulation of cell growth [9]; FF constitutive transcriptional repressor, thus negative regulator of interferon-beta expression; FF same DNA binding specificity as IRF-1; FF transforming potential, antagonizing IRF-1 [8]; FF required for normal hematopoiesis and B lymphopoieses [6]; FF enhanced levels after viral infection, peak after 4h [1]; FF functional in differentiated cells only [2]; FF IRF-1 and IRF-2 are critical transcription factors in the regulation of macrophage Interleukin 12 and IFN-gamma production [12]; XX IN T00402 IRF-8; mouse, Mus musculus. XX MX M00063 V$IRF2_01. MX M01882 V$IRF2_Q6. MX M08887 V$IRF_Q4. MX M00772 V$IRF_Q6. MX M00972 V$IRF_Q6_01. XX BS R06082. BS R06083. BS R06084. BS R06085. BS R06086. BS R06087. BS R06088. BS R06089. BS R06090. BS R06091. BS R06092. BS R06093. BS R06094. BS R06095. BS R06096. BS R04222. BS R19521. BS R26850. BS R00915. BS R00917. BS R00919. BS R14453. BS R26765. BS R00946. BS R27096. BS R27050. BS R24261. BS R22184. BS R04685. BS R21425. BS R01051. BS R57040. BS R26911. BS R03126. BS R26820. BS R01066. BS R12764. BS R12766. BS R20268. BS R24718. BS R24723. BS R27103. BS R26289. BS R26292. XX DR TRANSPATH: MO000007692. DR UniProtKB: P23906; DR PDB: 1IRF. DR PDB: 1IRG. XX RN [1]; RE0000097. RX PUBMED: 2475256. RA Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata T., Taniguchi T. RT Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes RL Cell 58:729-739 (1989). RN [2]; RE0000171. RX PUBMED: 2208287. RA Harada H., Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi T. RT Absence of the type I IFN system in EC cells: transcriptional activator (ITF-1) and repressor (IRF-2) genes are developmentally regulated RL Cell 63:303-312 (1990). RN [3]; RE0001630. RX PUBMED: 2038316. RA Pleiman C. M., Gimpel S. D., Park L. S., Harada H., Taniguchi T., Ziegler S. F. RT Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter RL Mol. Cell. Biol. 11:3052-3059 (1991). RN [4]; RE0002174. RX PUBMED: 1886766. RA Watanabe N., Sakakibara J., Hovanessian A. G., Taniguchi T., Fujita T. RT Activation of IFN-beta element by IRF-1 requires a post-translational event in addition to IRF-1 synthesis RL Nucleic Acids Res. 19:4421-4428 (1991). RN [5]; RE0002930. RX PUBMED: 7687740. RA Tanaka N., Kawakami T., Taniguchi T. RT Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system RL Mol. Cell. Biol. 13:4531-4538 (1993). RN [6]; RE0003461. RX PUBMED: 8402903. RA Matsuyama T., Kimura T., Kitagawa M., Pfeffer K., Kawakami T., Watanabe N., Kuendig T. M., Amakawa R., Kishihara K., Wakeham A., Potter J., Furlonger C. L., Narendran A., Suzuki H., Ohashi P. S., Paige C. J., Taniguchi T., Mak T. W. RT Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte developement RL Cell 75:83-97 (1993). RN [7]; RE0003469. RX PUBMED: 8197182. RA Bovolenta C., Driggers P. H., Marks M. S., Medin J. A., Politis A. D., Vogel S. N., Levy D. E., Sakaguchi K., Appella E., Coligan J. E., Ozato K. RT Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family RL Proc. Natl. Acad. Sci. USA 91:5046-5050 (1994). RN [8]; RE0003470. RX PUBMED: 8438157. RA Harada H., Kitagawa M., Tanaka N., Yamamoto H., Harada K., Ishihara M., Taniguchi T. RT Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2 RL Science 259:971-974 (1993). RN [9]; RE0011483. RX PUBMED: 7650042. RA Horiuchi M., Koike G., Yamada T., Mukyama M., Nakajima M., Dzau V. J. RT The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2 RL J. Biol. Chem. 270:20225-20230 (1995). RN [10]; RE0013380. RX PUBMED: 9562558. RA Furui J., Uegaki K., Yamazaki T., Shirakawa M., Swindells M. B., Harada H., Taniguchi T., Kyogoku Y. RT Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family RL Structure 6:491-500 (1998). RN [11]; RE0017830. RX PUBMED: 10586038. RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z. RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors. RL J. Immunol. 163:6468-6478 (1999). RN [12]; RE0017930. RX PUBMED: 10415056. RA Salkowski C. A., Kopydlowski K., Blanco J., Cody M. J., McNally R., Vogel S. N. RT IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice. RL J. Immunol. 163:1529-1536 (1999). RN [13]; RE0053394. RX PUBMED: 16301648. RA Guo Z., Garg S., Hill K. M., Jayashankar L., Mooney M. R., Hoelscher M., Katz J. M., Boss J. M., Sambhara S. RT A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 gene. RL J. Immunol. 175:7407-7418 (2005). XX //