AC T00402
XX
ID T00402
XX
DT 15.10.1992 (created); ewi.
DT 29.09.2015 (updated); mka.
CO Copyright (C), QIAGEN.
XX
FA IRF-8
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SY ICSBP; ICSBP1; IFN consensus sequence binding protein; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; IRF-8; IRF8.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000543 Irf8.
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CL C0022; trp; 3.5.3.0.8.
XX
SF N-terminal 115 AA have 45% identity with IRF-1, 47% identity with IRF-2 [1];
SF no similarity with IRFs for the C-terminal 309 AA;
SF direct interaction with either IRF-1 or IRF-2 enhances DNA-binding capability [2];
XX
CP spleen, thymus [1]; LPS and IFN gamma treated macrophage cells. [8]; RAW264.7, primary B cells, Peritoneal exudate macrophages [6].
CN brain, liver [1].
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FF activator [7];
FF repressor, acting through ISREs thus being an IRF-1 antagonist [3];
FF inhibits binding of ISGF3 to ISREs [2];
FF mRNA induced by IFN-gamma, not by IFN-alpha/beta [1];
FF transcription is activated through a STAT-like element [4];
FF important regulator in activated macrophages [7];
FF functionally synergizes and physically interacts with NF-ATc T01947 to activate the IL-12 p40 promoter in response to IFN-gamma and bacterial LPS [7];
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IN T00422 IRF-1; mouse, Mus musculus.
IN T00425 IRF-2; mouse, Mus musculus.
IN T01947 NFATc1; mouse, Mus musculus.
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MX M00699 V$ICSBP_Q6.
MX M01665 V$IRF8_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
XX
BS R72178.
BS R00423.
BS R26850.
BS R00950.
BS R00919.
BS R00927.
BS R14492.
BS R00163.
BS R69831.
BS R40207.
BS R01094.
BS R40105.
BS R35853.
BS R19546.
BS R19547.
BS R71473.
BS R71476.
BS R01051.
BS R67581.
BS R14476.
BS R14488.
BS R71536.
BS R24865.
BS R25627.
BS R26526.
BS R01061.
BS R01066.
BS R34761.
BS R73422.
BS R59804.
BS R30977.
XX
DR TRANSPATH: MO000007186.
DR TRANSCOMPEL: C00412.
DR TRANSCOMPEL: C00483.
DR TRANSCOMPEL: C00493.
DR TRANSCOMPEL: C00562.
DR TRANSCOMPEL: C00589.
DR TRANSCOMPEL: C00599.
DR UniProtKB: P23611;
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RN [1]; RE0002531.
RX PUBMED: 2111015.
RA Driggers P. H., Ennist D. L., Gleason S. L., Mak W.-H., Marks M. S., Levi B.-Z., Flanagan J. R., Appella E., Ozato K.
RT An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
RL Proc. Natl. Acad. Sci. USA 87:3743-3747 (1990).
RN [2]; RE0003469.
RX PUBMED: 8197182.
RA Bovolenta C., Driggers P. H., Marks M. S., Medin J. A., Politis A. D., Vogel S. N., Levy D. E., Sakaguchi K., Appella E., Coligan J. E., Ozato K.
RT Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family
RL Proc. Natl. Acad. Sci. USA 91:5046-5050 (1994).
RN [3]; RE0003475.
RX PUBMED: 7678054.
RA Nelson N., Marks M. S., Driggers P. H., Ozato K.
RT Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription
RL Mol. Cell. Biol. 13:588-599 (1993).
RN [4]; RE0003523.
RX PUBMED: 8321202.
RA Kanno Y., Kozak C. A., Schindler C., Driggers P. H., Ennist D. L., Gleason S. L., Darnell J. E., Ozato K.
RT The genomic structure of the murine ICSBP gene reveals the presence of the gamma-interferon-responsive element, to which an ISGF3alpha subunit (or similar) molecule binds
RL Mol. Cell. Biol. 13:3951-3963 (1993).
RN [5]; RE0003839.
RX PUBMED: 7768900.
RA Sharf R., Azriel A., Lejbkowicz F., Winograd S. S., Ehrlich R., Levi B.-Z.
RT Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors
RL J. Biol. Chem. 270:13063-13069 (1995).
RN [6]; RE0018007.
RX PUBMED: 10453013.
RA Marecki S., Atchison M. L., Fenton M. J.
RT Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages.
RL J. Immunol. 163:2713-2722 (1999).
RN [7]; RE0023747.
RX PUBMED: 12876285.
RA Zhu C., Rao K., Xiong H., Gagnidze K., Li F., Horvath C., Plevy S.
RT Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP.
RL J. Biol. Chem. 278:39372-39382 (2003).
RN [8]; RE0053317.
RX PUBMED: 10358195.
RA Kantakamalakul W., Politis A. D., Marecki S., Sullivan T., Ozato K., Fenton M. J., Vogel S. N.
RT Regulation of IFN consensus sequence binding protein expression in murine macrophages.
RL J. Immunol. 162:7417-7425 (1999).
RN [9]; RE0054797.
RX PUBMED: 16484229.
RA Zhao J., Kong H. J., Li H., Huang B., Yang M., Zhu C., Bogunovic M., Zheng F., Mayer L., Ozato K., Unkeless J., Xiong H.
RT IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways.
RL J. Biol. Chem. 281:10073-10080 (2006).
RN [10]; RE0055125.
RX PUBMED: 17579016.
RA Kong H. J., Anderson D. E., Lee C. H., Jang M. K., Tamura T., Tailor P., Cho H. K., Cheong J., Xiong H., Morse HC 3. r. d., Ozato K.
RT Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages.
RL J. Immunol. 179:26-30 (2007).
RN [11]; RE0055285.
RX PUBMED: 10618376.
RA Contursi C., Wang I. M., Gabriele L., Gadina M., O'Shea J., Morse HC 3. r. d., Ozato K.
RT IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.
RL Proc. Natl. Acad. Sci. USA 97:91-96 (2000).
RN [12]; RE0062943.
RX PUBMED: 19201866.
RA Kim J. Y., Ozato K.
RT The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.
RL J. Immunol. 182:2131-2140 (2009).
RN [13]; RE0064770.
RX PUBMED: 18802049.
RA Vila-del Sol V., Punzon C., Fresno M.
RT IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages.
RL J. Immunol. 181:4461-4470 (2008).
RN [14]; RE0066703.
RX PUBMED: 10364426.
RA Li W., Nagineni C. N., Efiok B., Chepelinsky A. B., Egwuagu C. E.
RT Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens.
RL Dev. Biol. 210:44-55 (1999).
RN [15]; RE0067461.
RX PUBMED: 20435892.
RA Zhang J., Qian X., Ning H., Yang J., Xiong H., Liu J.
RT Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1.
RL J. Biol. Chem. 285:21269-21281 (2010).
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