AC T01947
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ID T01947
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DT 18.11.1996 (created); ewi.
DT 12.05.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA NFATc1
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SY NF-AT2; NF-ATc; NF-ATc1; NFAT2; NFATC1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005447 Nfatc1.
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CL C0052; REL/NFAT; 6.1.3.0.1.
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SF Three domains of NFATc are required for ICSBP binding: N-terminal (overlapping with calcineurin-binding region), central (within DBD) and C-terminal [2];
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CP stimulated thymus, stimulated spleen [1]; RAW264.7 macrophages, both inactivated and activated [2]; [2] [1].
CN nonstimulated thymus, nonstimulated spleen, brain, gonad, heart, kidney, liver, muscle, skin [1].
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FF Inhibited by cyclosporin A and activated by TRANCE [3];
FF activator [2];
FF in T-cells is inducible by TPA and ionomycin [1];
FF in macrophages acts as a constitutive factor, its nuclear localization does not change upon cell activation [2];
FF functionally synergizes and physically interacts with ICSBP to activate the IL-12 p40 promoter in response to IFN-gamma and bacterial LPS [2];
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IN T00310 GATA-3; mouse, Mus musculus.
IN T00402 IRF-8; mouse, Mus musculus.
IN T02038 IRF-8; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
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MX M07264 V$NFAT2_Q4.
MX M01718 V$NFAT2_Q5.
MX M07606 V$NFAT2_Q5_01.
MX M07608 V$NFAT_Q3.
MX M00935 V$NFAT_Q4_01.
MX M00302 V$NFAT_Q6.
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BS R29502.
BS R19778.
BS R29501.
BS R13414.
BS R30108.
BS R30110.
BS R30111.
BS R08188.
BS R29894.
BS R27156.
BS R27157.
BS R25248.
BS R40644.
BS R55799.
BS R55802.
BS R65968.
BS R69485.
BS R37701.
BS R40318.
BS R14475.
BS R58308.
BS R29747.
BS R29750.
BS R41857.
BS R41860.
BS R24087.
BS R26633.
BS R30940.
BS R68417.
BS R31280.
BS R31282.
BS R34457.
BS R25664.
BS R64826.
BS R68942.
BS R30049.
BS R69011.
BS R35887.
BS R30106.
BS R57828.
BS R73137.
BS R14662.
BS R60497.
BS R37146.
BS R58748.
BS R58749.
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DR TRANSPATH: MO000026043.
DR TRANSCOMPEL: C00412.
DR TRANSCOMPEL: C00534.
DR TRANSCOMPEL: C00597.
DR UniProtKB: O88942; NFC1_MOUSE.
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RN [1]; RE0004486.
RX PUBMED: 8202141.
RA Northrop J. P., Ho S. N., Chen L., Thomas D. J., Timmerman L. A., Nolan G. P., Admon A., Crabtree G. R.
RT NF-AT components define a family of transcription factors targeted in T-cell activation
RL Nature 369:497-502 (1994).
RN [2]; RE0023747.
RX PUBMED: 12876285.
RA Zhu C., Rao K., Xiong H., Gagnidze K., Li F., Horvath C., Plevy S.
RT Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP.
RL J. Biol. Chem. 278:39372-39382 (2003).
RN [3]; RE0050519.
RX PUBMED: 16109714.
RA Kim K., Kim J. H., Lee J., Jin H. M., Lee S. H., Fisher D. E., Kook H., Kim K. K., Choi Y., Kim N.
RT Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.
RL J. Biol. Chem. 280:35209-35216 (2005).
RN [4]; RE0051515.
RX PUBMED: 17158449.
RA Besse A., Lamothe B., Campos A. D., Webster W. K., Maddineni U., Lin S. C., Wu H., Darnay B. G.
RT TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
RL J. Biol. Chem. 282:3918-3928 (2007).
RN [5]; RE0052993.
RX PUBMED: 17135271.
RA Lamothe B., Besse A., Campos A. D., Webster W. K., Wu H., Darnay B. G.
RT Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.
RL J. Biol. Chem. 282:4102-4112 (2007).
RN [6]; RE0055156.
RX PUBMED: 18772129.
RA Klein-Hessling S., Bopp T., Jha M. K., Schmidt A., Miyatake S., Schmitt E., Serfling E.
RT Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter.
RL J. Biol. Chem. 283:31030-31037 (2008).
RN [7]; RE0064853.
RX PUBMED: 18617513.
RA Lamothe B., Campos A. D., Webster W. K., Gopinathan A., Hur L., Darnay B. G.
RT The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.
RL J. Biol. Chem. 283:24871-24880 (2008).
RN [8]; RE0065478.
RX PUBMED: 19609356.
RA Kayama H., Koga R., Atarashi K., Okuyama M., Kimura T., Mak T. W., Uematsu S., Akira S., Takayanagi H., Honda K., Yamamoto M., Takeda K.
RT NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
RL PLoS Pathog. 5:e1000514 (2009).
RN [9]; RE0067101.
RX PUBMED: 20037154.
RA Kim J. H., Kim K., Jin H. M., Song I., Youn B. U., Lee S. H., Choi Y., Kim N.
RT Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.
RL J. Biol. Chem. 285:5224-5231 (2010).
RN [10]; RE0067619.
RX PUBMED: 18227156.
RA Qiao G., Li Z., Molinero L., Alegre M. L., Ying H., Sun Z., Penninger J. M., Zhang J.
RT T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
RL Mol. Cell. Biol. 28:2470-2480 (2008).
RN [11]; RE0069576.
RX PUBMED: 16849454.
RA Sun M., Ames K. T., Suzuki I., Fink P. J.
RT The cytoplasmic domain of Fas ligand costimulates TCR signals.
RL J. Immunol. 177:1481-1491 (2006).
RN [12]; RE0070715.
RX PUBMED: 21068407.
RA Kim K., Kim J. H., Youn B. U., Jin H. M., Kim N.
RT Pim-1 regulates RANKL-induced osteoclastogenesis via NF-kappaB activation and NFATc1 induction.
RL J. Immunol. 185:7460-7466 (2010).
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