TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01947 XX ID T01947 XX DT 18.11.1996 (created); ewi. DT 12.05.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA NFATc1 XX SY NF-AT2; NF-ATc; NF-ATc1; NFAT2; NFATC1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005447 Nfatc1. XX CL C0052; REL/NFAT; XX SF Three domains of NFATc are required for ICSBP binding: N-terminal (overlapping with calcineurin-binding region), central (within DBD) and C-terminal [2]; XX CP stimulated thymus, stimulated spleen [1]; RAW264.7 macrophages, both inactivated and activated [2]; [2] [1]. CN nonstimulated thymus, nonstimulated spleen, brain, gonad, heart, kidney, liver, muscle, skin [1]. XX FF Inhibited by cyclosporin A and activated by TRANCE [3]; FF activator [2]; FF in T-cells is inducible by TPA and ionomycin [1]; FF in macrophages acts as a constitutive factor, its nuclear localization does not change upon cell activation [2]; FF functionally synergizes and physically interacts with ICSBP to activate the IL-12 p40 promoter in response to IFN-gamma and bacterial LPS [2]; XX IN T00310 GATA-3; mouse, Mus musculus. IN T00402 IRF-8; mouse, Mus musculus. IN T02038 IRF-8; human, Homo sapiens. IN T01427 p300; human, Homo sapiens. XX MX M07264 V$NFAT2_Q4. MX M01718 V$NFAT2_Q5. MX M07606 V$NFAT2_Q5_01. MX M07608 V$NFAT_Q3. MX M00935 V$NFAT_Q4_01. MX M00302 V$NFAT_Q6. XX BS R29502. BS R19778. BS R29501. BS R13414. BS R30108. BS R30110. BS R30111. BS R08188. BS R29894. BS R27156. BS R27157. BS R25248. BS R40644. BS R55799. BS R55802. BS R65968. BS R69485. BS R37701. BS R40318. BS R14475. BS R58308. BS R29747. BS R29750. BS R41857. BS R41860. BS R24087. BS R26633. BS R30940. BS R68417. BS R31280. BS R31282. BS R34457. BS R25664. BS R64826. BS R68942. BS R30049. BS R69011. BS R35887. BS R30106. BS R57828. BS R73137. BS R14662. BS R60497. BS R37146. BS R58748. BS R58749. XX DR TRANSPATH: MO000026043. DR TRANSCOMPEL: C00412. DR TRANSCOMPEL: C00534. DR TRANSCOMPEL: C00597. DR UniProtKB: O88942; NFC1_MOUSE. XX RN [1]; RE0004486. RX PUBMED: 8202141. RA Northrop J. P., Ho S. N., Chen L., Thomas D. J., Timmerman L. A., Nolan G. P., Admon A., Crabtree G. R. RT NF-AT components define a family of transcription factors targeted in T-cell activation RL Nature 369:497-502 (1994). RN [2]; RE0023747. RX PUBMED: 12876285. RA Zhu C., Rao K., Xiong H., Gagnidze K., Li F., Horvath C., Plevy S. RT Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. RL J. Biol. Chem. 278:39372-39382 (2003). RN [3]; RE0050519. RX PUBMED: 16109714. RA Kim K., Kim J. H., Lee J., Jin H. M., Lee S. H., Fisher D. E., Kook H., Kim K. K., Choi Y., Kim N. RT Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. RL J. Biol. Chem. 280:35209-35216 (2005). RN [4]; RE0051515. RX PUBMED: 17158449. RA Besse A., Lamothe B., Campos A. D., Webster W. K., Maddineni U., Lin S. C., Wu H., Darnay B. G. RT TAK1-dependent signaling requires functional interaction with TAB2/TAB3. RL J. Biol. Chem. 282:3918-3928 (2007). RN [5]; RE0052993. RX PUBMED: 17135271. RA Lamothe B., Besse A., Campos A. D., Webster W. K., Wu H., Darnay B. G. RT Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. RL J. Biol. Chem. 282:4102-4112 (2007). RN [6]; RE0055156. RX PUBMED: 18772129. RA Klein-Hessling S., Bopp T., Jha M. K., Schmidt A., Miyatake S., Schmitt E., Serfling E. RT Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter. RL J. Biol. Chem. 283:31030-31037 (2008). RN [7]; RE0064853. RX PUBMED: 18617513. RA Lamothe B., Campos A. D., Webster W. K., Gopinathan A., Hur L., Darnay B. G. RT The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. RL J. Biol. Chem. 283:24871-24880 (2008). RN [8]; RE0065478. RX PUBMED: 19609356. RA Kayama H., Koga R., Atarashi K., Okuyama M., Kimura T., Mak T. W., Uematsu S., Akira S., Takayanagi H., Honda K., Yamamoto M., Takeda K. RT NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. RL PLoS Pathog. 5:e1000514 (2009). RN [9]; RE0067101. RX PUBMED: 20037154. RA Kim J. H., Kim K., Jin H. M., Song I., Youn B. U., Lee S. H., Choi Y., Kim N. RT Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1. RL J. Biol. Chem. 285:5224-5231 (2010). RN [10]; RE0067619. RX PUBMED: 18227156. RA Qiao G., Li Z., Molinero L., Alegre M. L., Ying H., Sun Z., Penninger J. M., Zhang J. RT T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. RL Mol. Cell. Biol. 28:2470-2480 (2008). RN [11]; RE0069576. RX PUBMED: 16849454. RA Sun M., Ames K. T., Suzuki I., Fink P. J. RT The cytoplasmic domain of Fas ligand costimulates TCR signals. RL J. Immunol. 177:1481-1491 (2006). RN [12]; RE0070715. RX PUBMED: 21068407. RA Kim K., Kim J. H., Youn B. U., Jin H. M., Kim N. RT Pim-1 regulates RANKL-induced osteoclastogenesis via NF-kappaB activation and NFATc1 induction. RL J. Immunol. 185:7460-7466 (2010). XX //