AC T02038
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ID T02038
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DT 16.01.1997 (created); hiwi.
DT 19.11.2014 (updated); pch.
CO Copyright (C), QIAGEN.
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FA IRF-8
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SY H-ICSBP; ICSBP; icsbp1; IFN consensus sequence binding protein; Interferon Cis-Sequence Binding Protein; interferon consensus sequence binding protein; interferon consensus sequence binding protein 1; interferon regulatory factor 8; IRF-8; IRF8.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004653 IRF8; HGNC: IRF8.
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CL C0022; trp; 3.5.3.0.8.
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SF within IRF family, demonstrates the highest homology to IRF-4;
SF binds to DNA in a complex with IRF-1 or IRF-2, or cooperatively with PU.1 or E47;
SF IAD of IRF-8 is responsible for the interactions with IRF family members, IRF-1and IRF-2 [2];
SF IAD is responsible for the interactions with Ets factor PU.1 and with bHLH factor E47 [3] [2];
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CP lymphoid and myeloid cells.
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FF cannot activate transcription alone [3];
FF activator in cooperation with PU.1 or E47 [3] [2];
FF activator in cooperation with NFATc [4];
FF important regulator in activated macrophages [4];
FF functionally synergizes and physically interacts with NF-ATc T01947 to activate the IL-12 p40 promoter in response to IFN-gamma and bacterial LPS [4];
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IN T01947 NFATc1; mouse, Mus musculus.
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MX M00699 V$ICSBP_Q6.
MX M01665 V$IRF8_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R30511.
BS R72178.
BS R64952.
BS R13560.
BS R20291.
BS R31466.
BS R64740.
BS R31463.
BS R64743.
BS R73681.
BS R14453.
BS R25968.
BS R26033.
BS R30651.
BS R30654.
BS R30648.
BS R30649.
BS R00945.
BS R31464.
BS R31475.
BS R74006.
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DR TRANSPATH: MO000023424.
DR TRANSCOMPEL: C00249.
DR TRANSCOMPEL: C00260.
DR TRANSCOMPEL: C00387.
DR TRANSCOMPEL: C00412.
DR TRANSCOMPEL: C00478.
DR TRANSCOMPEL: C00589.
DR UniProtKB: Q02556;
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RN [1]; RE0005306.
RX PUBMED: 1460054.
RA Weisz A., Marx P., Sharf R., Appella E., Driggers P. H., Ozato K., Levi B. Z.
RT Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes
RL J. Biol. Chem. 267:25589-25596 (1992).
RN [2]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [3]; RE0023151.
RX PUBMED: 12055236.
RA Meraro D., Gleit-Kielmanowicz M., Hauser H., Levi B. Z.
RT IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: characterization of a new subtype of IFN-stimulated response element.
RL J. Immunol. 168:6224-6231 (2002).
RN [4]; RE0023747.
RX PUBMED: 12876285.
RA Zhu C., Rao K., Xiong H., Gagnidze K., Li F., Horvath C., Plevy S.
RT Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP.
RL J. Biol. Chem. 278:39372-39382 (2003).
RN [5]; RE0065006.
RX PUBMED: 19074829.
RA McGough J. M., Yang D., Huang S., Georgi D., Hewitt S. M., Rocken C., Tanzer M., Ebert M. P., Liu K.
RT DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells.
RL Mol. Cancer Res. 6:1841-1851 (2008).
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