TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02038 XX ID T02038 XX DT 16.01.1997 (created); hiwi. DT 19.11.2014 (updated); pch. CO Copyright (C), QIAGEN. XX FA IRF-8 XX SY H-ICSBP; ICSBP; icsbp1; IFN consensus sequence binding protein; Interferon Cis-Sequence Binding Protein; interferon consensus sequence binding protein; interferon consensus sequence binding protein 1; interferon regulatory factor 8; IRF-8; IRF8. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004653 IRF8; HGNC: IRF8. XX CL C0022; trp; XX SF within IRF family, demonstrates the highest homology to IRF-4; SF binds to DNA in a complex with IRF-1 or IRF-2, or cooperatively with PU.1 or E47; SF IAD of IRF-8 is responsible for the interactions with IRF family members, IRF-1and IRF-2 [2]; SF IAD is responsible for the interactions with Ets factor PU.1 and with bHLH factor E47 [3] [2]; XX CP lymphoid and myeloid cells. XX FF cannot activate transcription alone [3]; FF activator in cooperation with PU.1 or E47 [3] [2]; FF activator in cooperation with NFATc [4]; FF important regulator in activated macrophages [4]; FF functionally synergizes and physically interacts with NF-ATc T01947 to activate the IL-12 p40 promoter in response to IFN-gamma and bacterial LPS [4]; XX IN T01947 NFATc1; mouse, Mus musculus. XX MX M00699 V$ICSBP_Q6. MX M01665 V$IRF8_Q6. MX M08887 V$IRF_Q4. MX M00772 V$IRF_Q6. MX M00972 V$IRF_Q6_01. XX BS R30511. BS R72178. BS R64952. BS R13560. BS R20291. BS R31466. BS R64740. BS R31463. BS R64743. BS R73681. BS R14453. BS R25968. BS R26033. BS R30651. BS R30654. BS R30648. BS R30649. BS R00945. BS R31464. BS R31475. BS R74006. XX DR TRANSPATH: MO000023424. DR TRANSCOMPEL: C00249. DR TRANSCOMPEL: C00260. DR TRANSCOMPEL: C00387. DR TRANSCOMPEL: C00412. DR TRANSCOMPEL: C00478. DR TRANSCOMPEL: C00589. DR UniProtKB: Q02556; XX RN [1]; RE0005306. RX PUBMED: 1460054. RA Weisz A., Marx P., Sharf R., Appella E., Driggers P. H., Ozato K., Levi B. Z. RT Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes RL J. Biol. Chem. 267:25589-25596 (1992). RN [2]; RE0017830. RX PUBMED: 10586038. RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z. RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors. RL J. Immunol. 163:6468-6478 (1999). RN [3]; RE0023151. RX PUBMED: 12055236. RA Meraro D., Gleit-Kielmanowicz M., Hauser H., Levi B. Z. RT IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: characterization of a new subtype of IFN-stimulated response element. RL J. Immunol. 168:6224-6231 (2002). RN [4]; RE0023747. RX PUBMED: 12876285. RA Zhu C., Rao K., Xiong H., Gagnidze K., Li F., Horvath C., Plevy S. RT Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. RL J. Biol. Chem. 278:39372-39382 (2003). RN [5]; RE0065006. RX PUBMED: 19074829. RA McGough J. M., Yang D., Huang S., Georgi D., Hewitt S. M., Rocken C., Tanzer M., Ebert M. P., Liu K. RT DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. RL Mol. Cancer Res. 6:1841-1851 (2008). XX //