AC T00422
XX
ID T00422
XX
DT 15.10.1992 (created); ewi.
DT 13.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA IRF-1
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SY IRF1; Interferon regulatory factor 1; IRF-1; IRF1; ISGF2.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001058 Irf1.
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CL C0022; trp; 3.5.3.0.1.
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SF IAD2 domain is conserved between IRF-1 and IRF-2, but is different in other family members [13];
SF IAD2 is responsible for protein-protein interactions [13];
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CP R3T3 [12]; RAW264.7 [17]; Peritoneal macrophages, Peritoneal macrophages + IFNgamma, Peritoneal macrophages + IFNgamma + LPS, Peritoneal macrophages + IFNgamma + IFNalpha/beta, Peritoneal macrophages + IFNgamma + LPS + IFNalpha/beta [18].
XX
FF Involved in the regulation of cell growth [12];
FF positive regulator of interferon-beta expression;
FF binds with the N-terminal part to interferon- and to virus-inducible enhancer elements [3];
FF same DNA binding specificity as IRF-2;
FF the C-terminal part comprises a trans-activating domain [9];
FF inducible by IL-6 [6];
FF immediate-early gene product of differentiated cells [1] [10] [2];
FF required for normal thymocyte development [8];
FF required for NO synthase induction in macrophages [11];
FF IRF-1 and IRF-2 are critical transcription factors in the regulation of macrophage Interleukin 12 and IFN-gamma production [14];
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IN T00402 IRF-8; mouse, Mus musculus.
IN T32110 SIRT1; mouse, Mus musculus.
XX
MX M00062 V$IRF1_01.
MX M07045 V$IRF1_Q5.
MX M00747 V$IRF1_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
XX
BS R24874.
BS R04222.
BS R19521.
BS R26854.
BS R26850.
BS R00918.
BS R00919.
BS R25968.
BS R14492.
BS R26722.
BS R26765.
BS R04683.
BS R02187.
BS R21425.
BS R25835.
BS R26819.
BS R32398.
BS R25792.
BS R74072.
BS R29679.
BS R13576.
BS R72849.
BS R72853.
BS R72855.
BS R65226.
BS R65228.
BS R65229.
BS R26911.
BS R26816.
BS R14488.
BS R66234.
BS R34137.
BS R25627.
BS R71520.
BS R26820.
BS R66237.
BS R01061.
BS R01066.
BS R08128.
BS R24506.
BS R26675.
BS R26845.
BS R12764.
BS R12766.
BS R59670.
BS R26869.
BS R26844.
BS R20268.
BS R24718.
BS R24723.
BS R63237.
XX
DR TRANSPATH: MO000007687.
DR TRANSCOMPEL: C00333.
DR TRANSCOMPEL: C00336.
DR TRANSCOMPEL: C00339.
DR TRANSCOMPEL: C00391.
DR UniProtKB: P15314;
DR PDB: 1IF1.
XX
RN [1]; RE0000099.
RX PUBMED: 3409321.
RA Miyamoto M., Fujita T., Kimura Y., Maruyama M., Harada H., Sudo Y., Miyata T., Taniguchi T.
RT Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That Specifically Binds to IFN-beta Gene Regulatory Elements
RL Cell 54:903-913 (1988).
RN [2]; RE0000171.
RX PUBMED: 2208287.
RA Harada H., Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi T.
RT Absence of the type I IFN system in EC cells: transcriptional activator (ITF-1) and repressor (IRF-2) genes are developmentally regulated
RL Cell 63:303-312 (1990).
RN [3]; RE0000373.
RX PUBMED: 2850164.
RA Fujita T., Sakakibara J., Sudo Y., Miyamoto M., Kimura Y., Taniguchi T.
RT Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements
RL EMBO J. 11:3397-3405 (1988).
RN [4]; RE0001630.
RX PUBMED: 2038316.
RA Pleiman C. M., Gimpel S. D., Park L. S., Harada H., Taniguchi T., Ziegler S. F.
RT Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter
RL Mol. Cell. Biol. 11:3052-3059 (1991).
RN [5]; RE0002174.
RX PUBMED: 1886766.
RA Watanabe N., Sakakibara J., Hovanessian A. G., Taniguchi T., Fujita T.
RT Activation of IFN-beta element by IRF-1 requires a post-translational event in addition to IRF-1 synthesis
RL Nucleic Acids Res. 19:4421-4428 (1991).
RN [6]; RE0002927.
RX PUBMED: 8168491.
RA Harroch S., Revel M., Chebath J.
RT Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA
RL EMBO J. 13:1942-1949 (1994).
RN [7]; RE0002930.
RX PUBMED: 7687740.
RA Tanaka N., Kawakami T., Taniguchi T.
RT Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system
RL Mol. Cell. Biol. 13:4531-4538 (1993).
RN [8]; RE0003461.
RX PUBMED: 8402903.
RA Matsuyama T., Kimura T., Kitagawa M., Pfeffer K., Kawakami T., Watanabe N., Kuendig T. M., Amakawa R., Kishihara K., Wakeham A., Potter J., Furlonger C. L., Narendran A., Suzuki H., Ohashi P. S., Paige C. J., Taniguchi T., Mak T. W.
RT Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte developement
RL Cell 75:83-97 (1993).
RN [9]; RE0003462.
RX PUBMED: 2911367.
RA Fujita T., Kimura Y., Miyamoto M., Barsoumian E. L., Taniguchi T.
RT Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1
RL Nature 337:270-272 (1989).
RN [10]; RE0003463.
RX PUBMED: 8265581.
RA Ruffner H., Reis L. F. L., Naef D., Weissmann C.
RT Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1
RL Proc. Natl. Acad. Sci. USA 90:11503-11507 (1993).
RN [11]; RE0003464.
RX PUBMED: 7510419.
RA Kamijo R., Harada H., Matsuyama T., Bosland M., Gerecitano J., Shapiro D., Le J., Koh S. I., Kimura T., Green S. J., Mak T. W., Taniguchi T., Vilcek J.
RT Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
RL Science 263:1612-1615 (1994).
RN [12]; RE0011483.
RX PUBMED: 7650042.
RA Horiuchi M., Koike G., Yamada T., Mukyama M., Nakajima M., Dzau V. J.
RT The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2
RL J. Biol. Chem. 270:20225-20230 (1995).
RN [13]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [14]; RE0017930.
RX PUBMED: 10415056.
RA Salkowski C. A., Kopydlowski K., Blanco J., Cody M. J., McNally R., Vogel S. N.
RT IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice.
RL J. Immunol. 163:1529-1536 (1999).
RN [15]; RE0019562.
RX PUBMED: 9422515.
RA ESCALANTE C.R., YIE J., THANOS D., AGGARWAL A.K.
RT Structure of IRF-1 with bound DNA reveals determinants of interferon regulation.
RL Nature 391:103-106 (1998).
RN [16]; RE0053348.
RX PUBMED: 17018642.
RA Negishi H., Fujita Y., Yanai H., Sakaguchi S., Ouyang X., Shinohara M., Takayanagi H., Ohba Y., Taniguchi T., Honda K.
RT Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.
RL Proc. Natl. Acad. Sci. USA 103:15136-15141 (2006).
RN [17]; RE0053394.
RX PUBMED: 16301648.
RA Guo Z., Garg S., Hill K. M., Jayashankar L., Mooney M. R., Hoelscher M., Katz J. M., Boss J. M., Sambhara S.
RT A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 gene.
RL J. Immunol. 175:7407-7418 (2005).
RN [18]; RE0054075.
RX PUBMED: 9510192.
RA Lopez-Collazo E., Hortelano S., Rojas A., Bosca L.
RT Triggering of peritoneal macrophages with IFN-alpha/beta attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kappaB activation.
RL J. Immunol. 160:2889-2895 (1998).
RN [19]; RE0055495.
RX PUBMED: 16172134.
RA Yoshida K., Yamamoto K., Kohno T., Hironaka N., Yasui K., Kojima C., Mukae H., Kadota J., Suzuki S., Honma K., Kohno S., Matsuyama T.
RT Active repression of IFN regulatory factor-1-mediated transactivation by IFN regulatory factor-4.
RL Int. Immunol. 17:1463-1471 (2005).
RN [20]; RE0064770.
RX PUBMED: 18802049.
RA Vila-del Sol V., Punzon C., Fresno M.
RT IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages.
RL J. Immunol. 181:4461-4470 (2008).
RN [21]; RE0065139.
RX PUBMED: 17273999.
RA Schmitz F., Heit A., Guggemoos S., Krug A., Mages J., Schiemann M., Adler H., Drexler I., Haas T., Lang R., Wagner H.
RT Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.
RL Eur. J. Immunol. 37:315-327 (2007).
RN [22]; RE0066703.
RX PUBMED: 10364426.
RA Li W., Nagineni C. N., Efiok B., Chepelinsky A. B., Egwuagu C. E.
RT Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens.
RL Dev. Biol. 210:44-55 (1999).
RN [23]; RE0068392.
RX PUBMED: 20308629.
RA Stirnweiss A., Ksienzyk A., Klages K., Rand U., Grashoff M., Hauser H., Kroger A.
RT IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
RL J. Immunol. 184:5179-5185 (2010).
RN [24]; RE0068850.
RX PUBMED: 20200270.
RA Hoshino K., Sasaki I., Sugiyama T., Yano T., Yamazaki C., Yasui T., Kikutani H., Kaisho T.
RT Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.
RL J. Immunol. 184:3341-3345 (2010).
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