AC T00454
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ID T00454
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DT 15.10.1992 (created); ewi.
DT 13.07.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA Egr-2
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SY EGR2 (human); Krox-20.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000547 Egr2.
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CL C0001; CH; 2.3.1.3.2.
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SF 3 zinc finger motifs;
SF phosphorylation;
SF glycosylation;
SF each finger spans 3 nucleotides;
SF discrimination between Egr-2 and Sp1 binding sites by 2 side chains;
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CP hindbrain (rhombomeres 3 and 5), neural crest, neural crest-derived boundary caps, glial components of cranial and spinal ganglia; in immune system, is expressed equally in both T-helpers 1 and T-helpers 2 cells [5]; expression in Schwann cell cultures [8].
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IN T19854 B-ATF; mouse, Mus musculus.
IN T02370 Nab1; mouse, Mus musculus.
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MX M00246 V$EGR2_01.
MX M05494 V$EGR2_04.
MX M07086 V$EGR2_05.
MX M08806 V$EGR2_Q4.
MX M02092 V$EGR2_Q6.
MX M08878 V$EGR_Q3.
MX M00807 V$EGR_Q6.
MX M00982 V$KROX_Q6.
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BS R68752.
BS R23685.
BS R67981.
BS R67983.
BS R67984.
BS R34770.
BS R61924.
BS R65494.
BS R65496.
BS R65498.
BS R71748.
BS R71749.
BS R71753.
BS R61964.
BS R18678.
BS R18679.
BS R00721.
BS R02085.
BS R18673.
BS R18674.
BS R56580.
BS R67684.
BS R61281.
BS R29700.
BS R67410.
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DR TRANSPATH: MO000024938.
DR UniProtKB: P08152;
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RN [1]; RE0000031.
RX PUBMED: 1674431.
RA Gilardi P., Schneider-Maunoury S., Charnay P.
RT Krox-20: a candidate gene for the regulation of pattern formation in the hindbrain
RL Biochimie 73:85-91 (1991).
RN [2]; RE0001889.
RX PUBMED: 2915691.
RA Wilkinson D. G., Bhatt S., Chavrier P., Bravo R., Charnay P.
RT Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse
RL Nature 337:461-464 (1989).
RN [3]; RE0001890.
RX PUBMED: 1898772.
RA Nardelli J., Gibson T. J., Vesque C., Charnay P.
RT Base sequence discrimination by zinc-finger DNA-binding domains
RL Nature 349:175-178 (1991).
RN [4]; RE0002757.
RX PUBMED: 2113174.
RA Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., Charnay P.
RT The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator
RL Mol. Cell. Biol. 10:3456-3467 (1990).
RN [5]; RE0022852.
RX PUBMED: 10755616.
RA Rengarajan J., Mittelstadt P. R., Mages H. W., Gerth A. J., Kroczek R. A., Ashwell J. D., Glimcher L. H.
RT Sequential involvement of NFAT and Egr transcription factors in FasL regulation.
RL Immunity 12:293-300 (2000).
RN [6]; RE0064955.
RX PUBMED: 17299135.
RA Lawson M. A., Tsutsumi R., Zhang H., Talukdar I., Butler B. K., Santos S. J., Mellon P. L., Webster N. J.
RT Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.
RL Mol. Endocrinol. 21:1175-1191 (2007).
RN [7]; RE0066559.
RX PUBMED: 17938205.
RA Dillon R. L., Brown S. T., Ling C., Shioda T., Muller W. J.
RT An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer.
RL Mol. Cell. Biol. 27:8648-8657 (2007).
RN [8]; RE0035616.
RX PUBMED: 16373334.
RA Leblanc S. E., Jang S. W., Ward R. M., Wrabetz L., Svaren J.
RT Direct regulation of myelin protein zero expression by the Egr2 transactivator.
RL J. Biol. Chem. 281:5453-5460 (2005).
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