AC T00486
XX
ID T00486
XX
DT 15.10.1992 (created); ewi.
DT 29.11.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Matalpha1p
XX
SY alpha1; MATalpha1; MATalpha1p.
XX
OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
XX
GE G000947 MATALPHA1.
XX
CL C0006; homeo; F3.1.1.0.4.
XX
SZ 175 AA; 20.4 kDa (gene) (calc.).
XX
SQ MFTSKPAFKIKNKASKSYRNTAVSKKLKEKRLAEHVRPSCFNIIRPLKKDIQIPVPSSRF
SQ LNKIQIHRIASGSQNTQFRQFNKTSIKSSKKYLNSFMAFRAYYSQFGSGVKQNVLSSLLA
SQ EEWHADKMQHGIWDYFAQQYNFINPGFGFVEWLTNNYAEVRGDGYWEDVFVHLAL
XX
SC Swiss-Prot#P0CY06
XX
FT 1 175 
PF04769; Mating-type protein MAT alpha.
XX
SF binds cooperatively with MCM1 to PQ elements of alpha-specific genes [3];
XX
FF activator [3];
FF alpha1+MCM1 activate alpha-specific genes;
FF responds to a-mating pheromone [3];
FF STE12 interaction is species-specific (no interaction with K. lactis STE12);
FF transcription of the alpha 1 gene requires STE5 which itself is under a1/alpha2 repression [8];
XX
IN T00500 Mcm1p; yeast, Saccharomyces cerevisiae.
IN T00772 Ste12p; yeast, Saccharomyces cerevisiae.
XX
BS R09080.
BS R36141.
BS R01047.
BS R01048.
BS R01364.
XX
DR EMBL: L00060;
DR EMBL: V01313;
DR EMBL: V01315;
DR EMBL: X59720;
DR UniProtKB: P0CY06;
XX
RN [1]; RE0000108.
RX PUBMED: 3304657.
RA Bender A., Sprague jr G. F.
RT MATalpha1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes
RL Cell 50:681-691 (1987).
RN [2]; RE0000644.
RX PUBMED: 2673922.
RA Passmore S., Elble R., Tye B.-K.
RT A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes
RL Genes Dev. 3:921-935 (1989).
RN [3]; RE0000724.
RX PUBMED: 1916267.
RA Sengupta P., Cochran B. H.
RT MATalpha1 can mediate gene activation by a-mating factor
RL Genes Dev. 5:1924-1934 (1991).
RN [4]; RE0000784.
RX PUBMED: 8339934.
RA Yuan Y.-l., Stroke H. L., Fields S.
RT Coupling of cell identity to signal response in yeast: interaction between the alpha1 and STE12 proteins
RL Genes Dev. 7:1584-1597 (1993).
RN [5]; RE0002875.
RX PUBMED: 1756728.
RA Primig M., Winkler H., Ammerer G.
RT The DNA binding and oligomerization domain of MCM1 is sufficient for its interaction with other regulatory proteins
RL EMBO J. 10:4209-4218 (1991).
RN [6]; RE0005133.
RX PUBMED: 7034964.
RA Astell C. R., Ahlstrom-Jonasson L., Smith M.
RT The sequence of the DNAs coding for the mating-type loci of saccharomyces cerevisiae
RL Cell 27:15-23 (1981).
RN [7]; RE0005134.
RX PUBMED: 6256656.
RA Nasmyth K. A., Tatchell K., Hall B. D., Astell C., Smith M.
RT A position effect in the control of transcription at yeast mating type loci
RL Nature 289:244-250 (1981).
RN [8]; RE0005135.
RX PUBMED: 8455598.
RA Mukai Y., Harashima S., Oshima Y.
RT Function of the Ste signal transduction pathway for mating pheromones sustains MATalpha1 transcription in Saccharomyces cerevisiae
RL Mol. Cell. Biol. 13:2050-2060 (1993).
RN [9]; RE0005136.
RX PUBMED: 1789011.
RA Jacquet M., Buhler J.-M., Iborra F., Francingues-Gaillard M.-C., Soustelle C.
RT The MAT locus revisited within a 9.8 kb fragment of chromosome III containing BUD5 and two new open reading frames
RL Yeast 7:881-888 (1991).
RN [10]; RE0005137.
RX PUBMED: 6276023.
RA Tatchell K., Nasmyth K. A., Hall B. D., Astell C. R., Smith M.
RT The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae.
RL Cell 27:25-35 (1981).
XX
//