AC T00653
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ID T00653
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DT 15.10.1992 (created); ewi.
DT 26.05.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA POU5F1 (Oct-5)
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SY Oct-3; Oct-3/4; Oct-4; Oct-5; OCT3; Oct3/4; Oct4; Otf-3; Otf-4; OTF3; Otf3-rs7; Otf3g; OTF4; POU domain, class 5, transcription factor 1; POU5F1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009191 Pou5f1.
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CL C0007; POU.
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SZ 285 AA; 31.7 kDa (cDNA) (calc.).
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SQ MAYCGPQVGLGLVPQVGVETLQPEGQAGARVESNSEGTSSEPCADRPNAVKLEKVEPTPE
SQ ESQDMKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSL
SQ KNMCKLRPLLEKWVEEADNNENLQEICKSETLVQARKRKRTSIENRVRWSLETMFLKCPK
SQ PSLQQITHIANQLGLEKDVVRVWFCNRRQKGKRSSIEYSQREEYEATGTPFPGGAVSFPL
SQ PPGPHFGTPGYGSPHFTTLYSVPFPEGEAFPSVPVTALGSPMHSN
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SC edited from Swiss-Prot #P20263 according to [4]
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FT 64 138 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 64 138 
SM00352; pou.
FT 154 214 
PS50071; HOMEOBOX_2.
FT 154 216 
PS50550; POU_HOMEODOMAIN.
FT 156 218 
SM00389; HOX_1.
FT 157 213 
PF00046; Homeobox domain.
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SF arises from the POU5F1 T00651 gene from a downstream translation initiation codon [5] [2] [3] [4];
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CP (day 7.5, 8.5 embryos); high in cell lines resembling the preimplantation embryo (F9 EC, ES, P19 EC, GCLB cells), morula, blastocyst, inner cell mass, hypoblast; undifferentiated ES cells, testis, ovary, differentiated ES cells [7].
CN granulated metrial gland cell (GMGC) in the placenta [6]; brain, heart, kidney, spleen, muscle, lung, stomach, thymus, liver, skin [7].
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FF activator during early mouse development [5] [1] [3];
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MX M03837 V$OCT3_Q6.
MX M01125 V$OCT4_01.
MX M01124 V$OCT4_02.
MX M00795 V$OCT_Q6.
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BS R67955.
BS R19366.
BS R00864.
BS R00870.
BS R01885.
BS R19260.
BS R60511.
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DR TRANSPATH: MO000025083.
DR TRANSCOMPEL: C00512.
DR TRANSCOMPEL: C00587.
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RN [1]; RE0000059.
RX PUBMED: 1967980.
RA Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., Hamada H.
RT A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
RL Cell 60:461-472 (1990).
RN [2]; RE0000423.
RX PUBMED: 2573523.
RA Schoeler H. R., Hatzopoulos A. K., Balling R., Suzuki N., Gruss P.
RT A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor
RL EMBO J. 8:2543-2550 (1989).
RN [3]; RE0000424.
RX PUBMED: 2573524.
RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P.
RT Octamer binding proteins confer transcriptional activity in early mouse embryogenesis
RL EMBO J. 8:2551-2557 (1989).
RN [4]; RE0001804.
RX PUBMED: 1690859.
RA Schoeler H. R., Ruppert S., Suzuki N., Chowdhury K., Gruss P.
RT New type of POU domain in germ line-specific protein Oct-4
RL Nature 344:435-439 (1990).
RN [5]; RE0002740.
RX PUBMED: 2357966.
RA Schoeler H. R., Dressler G. R., Balling R., Rohdewohld H., Gruss P.
RT Oct-4: a germline-specific transcription factor mapping to the mouse t-complex
RL EMBO J. 9:2185-2195 (1990).
RN [6]; RE0025446.
RX PUBMED: 9649510.
RA Botquin V., Hess H., Fuhrmann G., Anastassiadis C., Gross M. K., Vriend G., Scholer H. R.
RT New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2.
RL Genes Dev. 12:2073-2090 (1998).
RN [7]; RE0036388.
RX PUBMED: 12665572.
RA Tokuzawa Y., Kaiho E., Maruyama M., Takahashi K., Mitsui K., Maeda M., Niwa H., Yamanaka S.
RT Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
RL Mol. Cell. Biol. 23:2699-2708 (2003).
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//