AC T00656
XX
ID T00656
XX
DT 15.10.1992 (created); ewi.
DT 18.06.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA POU3F1
XX
SY Oct-6; SCIP (rat); Tst-1 (rat).
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009192 Pou3f1.
XX
CL C0007; POU.
XX
SZ 449 AA; 45.3 kDa (cDNA) (calc.).
XX
SQ MATTAQYLPRGPGGGAGGTGPLMHPDAAAAAAAAAERLHAGAAYREVQKLMHHEWLGAGA
SQ GHPVGLAHPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGRADDGGGGGGFHARLVHQGAA
SQ HAGAAWAQGGTAHHLGPAMSPSPGAGGGHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGG
SQ AGPGLHHALHEDGHEAQLEPSPPPHLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSSVG
SQ EHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLS
SQ FKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCP
SQ KPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGG
SQ SASPPSAPPPPPPAALHHHHHHTLPGSVQ
XX
SC Swiss-Prot#P21952
XX
FT 245 319 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 245 319 
SM00352; pou.
FT 335 395 
PS50071; HOMEOBOX_2.
FT 335 397 
PS50550; POU_HOMEODOMAIN.
FT 337 399 
SM00389; HOX_1.
FT 338 394 
PF00046; Homeobox domain.
XX
SF Oct -6 lacks one Ala within the poly-Ala stretch 27-35 [3];
SF the His-rich region contains a stretch of His-(Gy/Ala)-repeats [3];
SF POUs domain induces DNA-bending [4];
SF the N-terminal third contains a potent Gly-/Ala-rich trans-activation domain with internal functional redundancy [7];
XX
CP undifferentiated embryonic cells, glial precursor cells of CNS (O-2A cells) and PNS (Schwann cells) [3].
CN heart, kidney, liver, muscle, salivary gland, spleen, testis [6].
XX
FF activator or repressor (shown for the rat homolog) [7] [3];
FF stimulates viral replication by enhancing large T-antigen expression [8];
FF physically interacts and synergistically cooperates with T-Ag in inducing viral gene transcription [10];
FF down-regulated during embryonic stem cell differentiation [3];
FF re-appearing in Schwann (glial precursor) cells immediately before they differentiate into myelin--forming cells [3];
FF found in the cortex, but not in the cerebellum during brain development [3];
XX
IN T00788 T-Ag; SV40, simian virus 40.
XX
MX M00795 V$OCT_Q6.
MX M07331 V$POU3F1_Q2.
MX M03842 V$POU3F1_Q6.
MX M00133 V$TST1_01.
MX M01316 V$TST1_02.
XX
BS R01176.
BS R16335.
BS R16340.
BS R16341.
BS R02824.
BS R68436.
BS R68441.
BS R68446.
BS R68447.
BS R00870.
BS R01885.
BS R67204.
BS R63282.
BS R63319.
BS R63323.
BS R63325.
BS R63337.
BS R63339.
BS R63568.
BS R63571.
BS R63572.
BS R63573.
BS R63576.
BS R63340.
BS R63580.
BS R63582.
BS R63583.
BS R63586.
BS R63587.
BS R63588.
BS R63341.
BS R63347.
BS R63350.
BS R63355.
BS R63356.
BS R63358.
BS R63359.
BS R63362.
BS R63363.
BS R63366.
BS R63367.
BS R63368.
BS R63372.
BS R63373.
BS R63374.
BS R63377.
BS R63378.
BS R63379.
BS R63385.
BS R63386.
BS R63389.
BS R63393.
BS R63396.
BS R63398.
BS R63404.
BS R63405.
BS R63424.
BS R63425.
BS R63426.
BS R63430.
BS R63431.
BS R63435.
BS R63437.
BS R63439.
BS R63441.
BS R63442.
BS R63473.
BS R63480.
BS R63495.
BS R63499.
BS R63500.
BS R63503.
BS R63510.
BS R63514.
BS R63516.
BS R63519.
BS R63520.
BS R63530.
BS R63566.
BS R22960.
BS R57651.
BS R57656.
BS R16357.
BS R15132.
BS R02228.
BS R04725.
XX
DR TRANSPATH: MO000046032.
DR TRANSCOMPEL: C00461.
DR TRANSCOMPEL: C00587.
DR EMBL: X54628; MMOCT6GR.
DR EMBL: X56959; MDSCIP.
DR EMBL: X57482; MMOCT6R.
DR UniProtKB: P21952; OCT6_MOUSE.
XX
RN [1]; RE0000423.
RX PUBMED: 2573523.
RA Schoeler H. R., Hatzopoulos A. K., Balling R., Suzuki N., Gruss P.
RT A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor
RL EMBO J. 8:2543-2550 (1989).
RN [2]; RE0000424.
RX PUBMED: 2573524.
RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P.
RT Octamer binding proteins confer transcriptional activity in early mouse embryogenesis
RL EMBO J. 8:2551-2557 (1989).
RN [3]; RE0000462.
RX PUBMED: 1976514.
RA Suzuki N., Rohdewohld H., Neuman T., Gruss P., Schoeler H. R.
RT Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain
RL EMBO J. 9:3723-3732 (1990).
RN [4]; RE0000528.
RX PUBMED: 1915275.
RA Verrijzer C. P., van Oosterhout J. A. W. M., van Weperen W. W., van der Vliet P. C.
RT POU proteins bend DNA via the POU-specific domain
RL EMBO J. 10:3007-3014 (1991).
RN [5]; RE0002096.
RX PUBMED: 1979677.
RA Meijer D., Graus A., Kraay R., Langeveld A., Mulder M. P., Grosveld G.
RT The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells
RL Nucleic Acids Res. 18:7357-7365 (1990).
RN [6]; RE0004402.
RX PUBMED: 1565620.
RA Hara Y., Rovescalli A. C., Kim Y., Nirenberg M.
RT Structure and evolution of four POU domain genes expressed in mouse brain
RL Proc. Natl. Acad. Sci. USA 89:3280-3284 (1992).
RN [7]; RE0004404.
RX PUBMED: 1594443.
RA Meijer D., Graus A., Grosveld G.
RT Mapping the transactivation domain of the Ict-6 POU transcription factor
RL Nucleic Acids Res. 20:2241-2247 (1992).
RN [8]; RE0004405.
RX PUBMED: 8389455.
RA Wegner M., Drolet D. W., Rosenfeld M. G.
RT Regulation of JC virus by the POU-domain transcription factor Tst-1: Implications for progressive multifocal leukoencephalopathy
RL Proc. Natl. Acad. Sci. USA 90:4743-4747 (1993).
RN [9]; RE0004407.
RX PUBMED: 1840678.
RA Zimmerman E. C., Jones C. M., Fet V., Hogan B. L. M., Magnuson M. A.
RT Nucleotide sequence of mouse SCIP cDNA, a POU-domain transcription factor
RL Nucleic Acids Res. 19:956-956 (1991).
RN [10]; RE0004411.
RX PUBMED: 8022800.
RA Renner K., Leger H., Wegner M.
RT The POU domain protein Tst-1 and papovaviral large tumor antigen function synergistically to stimulate glia-specific gene expression of JC virus
RL Proc. Natl. Acad. Sci. USA 91:6433-6437 (1994).
XX
//