![TRANSFAC-Logo](/transfac_factor/images/logo_genexplain.png)
AC T00685
XX
ID T00685
XX
DT 15.10.1992 (created); ewi.
DT 17.03.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA PEA3
XX
SY E1A (adenovirus) enhancer-binding factor; E1A-F; ETV4; PEA-3.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G007338 ETV4; HGNC: ETV4.
XX
CL C0016; ETS; 3.5.2.2.5.
XX
CP Highly expressed in 184B5/HER-2 breast cancer cells than in 184B5 cells [6].
XX
FF monomeric DNA-binding;
FF serum-activated, target for several non-nuclear oncogenes (Src, Py-middle T, Ha-Ras, mos, raf, not: fos) [1];
XX
IN T01427 p300; human, Homo sapiens.
XX
MX M00971 V$ETS_Q6.
MX M03982 V$ETV4_01.
MX M02066 V$PEA3_02.
MX M00655 V$PEA3_Q6.
MX M03579 V$PEA3_Q6_02.
XX
BS R01993.
BS R01995.
BS R01996.
BS R26773.
BS R02153.
BS R38733.
BS R26406.
BS R34113.
BS R01640.
BS R21562.
BS R26665.
BS R38715.
BS R58800.
BS R58801.
BS R01639.
BS R26529.
BS R26530.
BS R03058.
BS R26693.
BS R26694.
BS R26695.
BS R26400.
BS R23482.
BS R21721.
BS R08492.
BS R66806.
BS R25005.
BS R25448.
BS R25449.
BS R01224.
BS R02232.
XX
DR TRANSPATH: MO000046009.
DR UniProtKB: P43268; ETV4_HUMAN.
XX
RN [1]; RE0000395.
RX PUBMED: 2555163.
RA Wasylyk C., Flores P., Gutman A., Wasylyk B.
RT PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes
RL EMBO J. 8:3371-3378 (1989).
RN [2]; RE0001866.
RX PUBMED: 2114554.
RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D.
RT The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation
RL Nature 346:191-193 (1990).
RN [3]; RE0002193.
RX PUBMED: 2532319.
RA Yoshida K., Narita M., Fujinaga K.
RT Binding sites of HeLa cell nuclear proteins on the upstream region of adenovirus type 5 E1A gene
RL Nucleic Acids Res. 17:10015-10034 (1989).
RN [4]; RE0002743.
RX PUBMED: 2162765.
RA Gutman A., Wasylyk B.
RT The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites
RL EMBO J. 9:2241-2246 (1990).
RN [5]; RE0005328.
RX PUBMED: 8441666.
RA Higashino F., Yoshida K., Fujinaga A., Kamio K., Fujinaga K.
RT Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family
RL Nucleic Acids Res. 21:547-553 (1993).
RN [6]; RE0053822.
RX PUBMED: 11901151.
RA Subbaramaiah K., Norton L., Gerald W., Dannenberg A. J.
RT Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3.
RL J. Biol. Chem. 277:18649-18657 (2002).
XX
//