AC T00775
XX
ID T00775
XX
DT 03.12.1992 (created); ewi.
DT 27.05.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA Swi4p
XX
SY SWI4; SWI4p; YER111C.
XX
OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
XX
GE G004181 SWI4.
XX
CL C0009; ZIP; F1.1.6.0.2.
XX
SZ 1093 AA; 123.8 kDa (cDNA) (calc.), 120-130 kDa (SDS)
XX
SQ MPFDVLISNQKDNTNHQNITPISKSVLLAPHSNHPVIEIATYSETDVYECYIRGFETKIV
SQ MRRTKDDWINITQVFKIAQFSKTKRTKILEKESNDMQHEKVQGGYGRFQGTWIPLDSAKF
SQ LVNKYEIIDPVVNSILTFQFDPNNPPPKRSKNSILRKTSPGTKITSPSSYNKTPRKKNSS
SQ SSTSATTTAANKKGKKNASINQPNPSPLQNLVFQTPQQFQVNSSMNIMNNNDNHTTMNFN
SQ NDTRHNLINNISNNSNQSTIIQQQKSIHENSFNNNYSATQKPLQFFPIPTNLQNKNVALN
SQ NPNNNDSNSYSHNIDNVINSSNNNNNGNNNNLIIVPDGPMQSQQQQQHHHEYLTNNFNHS
SQ MMDSITNGNSKKRRKKLNQSNEQQFYNQQEKIQRHFKLMKQPLLWQSFQNPNDHHNEYCD
SQ SNGSNNNNNTVASNGSSIEVFSSNENDNSMNMSSRSMTPFSAGNTSSQNKLENKMTDQEY
SQ KQTILTILSSERSSDVDQALLATLYPAPKNFNINFEIDDQGHTPLHWATAMANIPLIKML
SQ ITLNANALQCNKLGFNCITKSIFYNNCYKENAFDEIISILKICLITPDVNGRLPFHYLIE
SQ LSVNKSKNPMIIKSYMDSIILSLGQQDYNLLKICLNYQDNIGNTPLHLSALNLNFEVYNR
SQ LVYLGASTDILNLDNESPASIMNKFNTPAGGSNSRNNNTKADRKLARNLPQKNYYQQQQQ
SQ QQQPQNNVKIPKIIKTQHPDKEDSTADVNIAKTDSEVNESQYLHSNQPNSTNMNTIMEDL
SQ SNINSFVTSSVIKDIKSTPSKILENSPILYRRRSQSISDEKEKAKDNENQVEKKKDPLNS
SQ VKTAMPSLESPSSLLPIQMSPLGKYSKPLSQQINKLNTKVSSLQRIMGEEIKNLDNEVVE
SQ TESSISNNKKRLITIAHQIEDAFDSVSNKTPINSISDLQSRIKETSSKLNSEKQNFIQSL
SQ EKSQALKLATIVQDEESKVDMNTNSSSHPEKQEDEEPIPKSTSETSSPKNTKADAKFSNT
SQ VQESYDVNETLRLATELTILQFKRRMTTLKISEAKSKINSSVKLDKYRNLIGITIENIDS
SQ KLDDIEKDLRANA
XX
SC Swiss-Prot#P25302
XX
FT 36 155 
DNA-binding domain [6].
FT 59 143 
PF02292; APSES domain.
FT 520 549 
SM00248; ANK_2a.
FT 520 552 
PF00023; Ankyrin repeat.
FT 520 552 
PS50088; ANK_REPEAT.
FT 520 552 
PS50297; ANK_REP_REGION.
FT 635 678 
PS50297; ANK_REP_REGION.
FT 641 670 
SM00248; ANK_2a.
FT 641 673 
PF00023; Ankyrin repeat.
FT 641 673 
PS50088; ANK_REPEAT.
FT 656 956 PF00478; IMP dehydrogenase / GMP reductase domain.
XX
SF 2 TPLH repeats, important for interaction with non-SWI6 proteins;
SF several N/Q-rich clusters are scattered over the molecule;
SF together with SWI6, it forms the factor SBF in which it is the main DNA-binding moiety [5];
SF moreover, it is an essential component of DSC1 [4];
SF ankyrin-repeat-like region of homology with Swi4p and S. pombe cdc10 [2];
XX
FF mediates cell-cycle dependent transcription of HO gene and START-specific transcription [3];
XX
IN T01013 Swi6p; yeast, Saccharomyces cerevisiae.
XX
MX M01609 F$SWI4_01.
MX M02032 F$SWI4_Q6.
MX M08830 F$SWI4_Q6_01.
XX
BS R03735.
BS R00719.
BS R00720.
BS R03752.
BS R34951.
BS R34952.
BS R34953.
BS R34954.
BS R67963.
XX
DR EMBL: X51606; SCSWI4.
DR UniProtKB: P25302; SWI4_YEAST.
XX
RN [1]; RE0001703.
RX PUBMED: 8423776.
RA Sidorova J., Breeden L.
RT Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae
RL Mol. Cell. Biol. 13:1069-1077 (1993).
RN [2]; RE0001858.
RX PUBMED: 2689885.
RA Andrews B. J., Herskowitz I.
RT The yeast SWI4 protein contains a motif present in developmental regulators and is part of a complex involved in cell-cycle-dependent transcription
RL Nature 342:830-833 (1989).
RN [3]; RE0005302.
RX PUBMED: 1465410.
RA Andrews B. J., Moore L. A.
RT Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro
RL Proc. Natl. Acad. Sci. USA 89:11852-11856 (1992).
RN [4]; RE0005501.
RX PUBMED: 1608450.
RA Lowndes N. F., Johnson A. L., Breeden L., Johnston L. H.
RT SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast
RL Nature 357:505-508 (1992).
RN [5]; RE0005502.
RX PUBMED: 1608451.
RA Dirick L., Moll T., Auer H., Nasmyth K.
RT A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast
RL Nature 357:508-513 (1992).
RN [6]; RE0005503.
RX PUBMED: 1386897.
RA Primig M., Sockanathan S., Auer H., Nasmyth K.
RT Anatomy of a transcription factor important for the start of the cell cycle in Saccharomyces cerevisiae
RL Nature 358:593-597 (1992).
XX
//