AC T01013
XX
ID T01013
XX
DT 19.02.1994 (created); ewi.
DT 29.11.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Swi6p
XX
SY PSL8; SDS11; SWI6; SWI6p; YLR182W.
XX
OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
XX
GE G004184 SWI6.
XX
CL C0009; ZIP; F1.1.6.0.1.
XX
SZ 803 AA; 90.6 kDa (cDNA) (calc.).
XX
SQ MALEEVVRYLGPHNEIPLTLTRDSETGHFLLKHFLPILQQYHDTGNINETNPDSFPTDEE
SQ RNKLLAHYGIAVNTDDRGELWIELEKCLQLLNMLNLFGLFQDAFEFEEPETDQDEEDPSH
SQ SKLPENKTKSENSKDNISSKRINNLQDMSLDSDAHRELGSPLKKLKIDTSVIDAESDSTP
SQ NTARGKPNDDINKGPSGDNENNGTDDNDRTAGPIITFTHDLTSDFLSSPLKIMKALPSPV
SQ VNDNEQKMKLEAFLQRLLFPEIQEMPTSLNNDSSNRNSEGGSSNQQQQHVSFDSLLQEVN
SQ DAFPNTQLNLNIPVDEHGNTPLHWLTSIANLELVKHLVKHGSNRLYGDNMGESCLVKAVK
SQ SVNNYDSGTFEALLDYLYPCLILEDSMNRTILHHIIITSGMTGCSAAAKYYLDILMGWIV
SQ KKQNRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSNGDTCLNIAARL
SQ GNISIVDALLDYGADPFIANKSGLRPVDFGAGTSKLQNTNGGDENSKMVSKGDYDGQKNG
SQ KAKKIRSQLLKNPPETTSLINDVQNLLNSISKDYENETVQYNEKLEKLHKELNEQREELA
SQ NSREQLANVKQLKDEYSLMQEQLTNLKAGIEEEEESFREESKKLGIIADESSGIDWDSSE
SQ YDADEPFKVEFLSDFLEDKLQKNYEGDISKLLEAESKEQIMEQIRNQLPAEKIQSMLPPT
SQ VLLKARINAYKRNDKHLTNVLDTISTKQSELENKFRRVLSLCLKIDENKVDNMLDGLLQA
SQ ISSEDPQDIDTDEMQDFLKKHAS
XX
SC Swiss-Prot#P09959
XX
FT 145 286 
transcriptional activator (TAR1) [9].
FT 288 612 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 317 346 
SM00248; ANK_2a.
FT 317 349 
PF00023; Ankyrin repeat.
FT 317 349 
PS50088; ANK_REPEAT.
FT 317 375 
PS50297; ANK_REP_REGION.
FT 463 511 
PS50297; ANK_REP_REGION.
FT 469 498 
SM00248; ANK_2a.
FT 469 501 
PF00023; Ankyrin repeat.
FT 469 501 
PS50088; ANK_REPEAT.
FT 653 669 transcriptional activator (TAR2) [9].
XX
SF 4 ankyrin (ANK) repeats [10];
SF ankyrin-repeat-like region of homology with Swi4p T00775 and S. pombe Cdc10p T01252 [4];
SF Swi6p has a structure very similar to that of the p53 binding protein 53BP2 [10];
SF together with Swi4p T00775 formation of the factor SBF [7];
SF essential component of DSC1 [6];
SF together with Mbp1p T03480 an essential part of MBF, an MCB element (Mlu I cell cycle box)-binding complex [8];
XX
FF mediates cell-cycle dependent transcription of HO gene and of G1-specific genes in general [2];
FF mutations in Swi6p suppress the silencing defect of the HMR-E silencer ARS consensus element and of RAP1 [11];
XX
IN T00775 Swi4p; yeast, Saccharomyces cerevisiae.
XX
BS R03735.
BS R00719.
BS R00720.
BS R03752.
XX
DR EMBL: X06238;
DR UniProtKB: P09959;
XX
RN [1]; RE0000080.
RX PUBMED: 2649246.
RA Andrews B. J., Herskowitz I.
RT Identification of a DNA Binding Factor Involved in Cell-Cycle Control of the Yeast HO Gene
RL Cell 57:21-29 (1989).
RN [2]; RE0000261.
RX PUBMED: 1832338.
RA Nasmyth K., Dirick L.
RT The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast
RL Cell 66:995-1013 (1991).
RN [3]; RE0001703.
RX PUBMED: 8423776.
RA Sidorova J., Breeden L.
RT Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae
RL Mol. Cell. Biol. 13:1069-1077 (1993).
RN [4]; RE0001858.
RX PUBMED: 2689885.
RA Andrews B. J., Herskowitz I.
RT The yeast SWI4 protein contains a motif present in developmental regulators and is part of a complex involved in cell-cycle-dependent transcription
RL Nature 342:830-833 (1989).
RN [5]; RE0005302.
RX PUBMED: 1465410.
RA Andrews B. J., Moore L. A.
RT Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro
RL Proc. Natl. Acad. Sci. USA 89:11852-11856 (1992).
RN [6]; RE0005501.
RX PUBMED: 1608450.
RA Lowndes N. F., Johnson A. L., Breeden L., Johnston L. H.
RT SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast
RL Nature 357:505-508 (1992).
RN [7]; RE0005502.
RX PUBMED: 1608451.
RA Dirick L., Moll T., Auer H., Nasmyth K.
RT A central role for SWI6 in modulating cell cycle Start-specific transcription in yeast
RL Nature 357:508-513 (1992).
RN [8]; RE0014664.
RX PUBMED: 8372350.
RA Koch C., Moll T., Neuberg M., Ahorn H., Nasmyth K.
RT A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase
RL Science 261:1551-1557 (1993).
RN [9]; RE0015487.
RX PUBMED: 9719633.
RA Sedgwick S. G., Taylor I. A., Adam A. C., Spanos A., Howell S., Morgan B. A., Treiber M. K., Kanuga N., Banks G. R., Foord R., Smerdon S. J.
RT Structural and functional architecture of the yeast cell-cycle transcription factor swi6.
RL J. Mol. Biol. 281:763-775 (1998).
RN [10]; RE0015529.
RX PUBMED: 9521763.
RA Ewaskow S. P., Sidorova J. M., Hendle J., Emery J. C., Lycan D. E., Zhang K. Y., Breeden L. L.
RT Mutation and modeling analysis of the Saccharomyces cerevisiae Swi6 ankyrin repeats
RL Biochemistry 37:4437-4450 (1998).
RN [11]; RE0015545.
RX PUBMED: 7791768.
RA Laman H., Balderes D., Shore D.
RT Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae.
RL Mol. Cell. Biol. 15:3608-3617 (1995).
XX
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