AC T00884
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ID T00884
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DT 15.10.1992 (created); ewi.
DT 19.11.2001 (updated); mas.
CO Copyright (C), QIAGEN.
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FA VDR
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SY 1,25-dihydroxyvitamin D3 receptor; NR1I1; VDR; vitamin D receptor.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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CL C0002; CC (rec).
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SZ 451 AA; 51.3 kDa (calc.), 60.3 kDa (SDS-PAGE) [4] or 67 kDa [5] (SDS-PAGE) [4] [5]
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SQ MSELRGSWDEQQQSMAYLPDADMDTVAASTSLPDPAGDFDRNVPRICGVCGDRATGFHFN
SQ AMTCEGCKGFFRRSMKRKAMFTCPFNGDCKITKDNRRHCQACRLKRCVDIGMMKEFILTD
SQ EEVQRKREMILKRKEEEALKESLKPKLSEEQQKVIDTLLEAHHKTFDTTYSDFNKFRPPV
SQ RSKFSSRMATHSSSVVSQDFSSEDSNDVFGSDAFAAFPEPMEPQMFSNLDLSEESDESPS
SQ MNIELPHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSN
SQ QSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGLKKLNLHEEEHVLLMAI
SQ CILSPDRPGVQDTSLVESIQDRLSDILQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEE
SQ HSKQYRCLSFQPEHSMQLTPLVLEVFGNEIS
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SC translated from EMBL #AF011356
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FT 44 115 
SM00399; c4gold.
FT 44 119 
PS51030; NUCLEAR_REC_DBD_2.
FT 45 120 
PF00105; Zinc finger, C4 type (two domains).
FT 256 418 
SM00430; holi.
FT 259 445 
PF00104; Ligand-binding domain of nuclear hormon.
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SF usage of two different translational initiation sites generates two different protein forms: first form (451 aa, 60.3 kDa) starting from pos. 1 is translated from suboptimal ATG context, second form (437 aa, 58.6 kDa) starting from pos. 15 (second Methionine) is translated from optimal ATG context [4];
SF phosphorylation;
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CP (adult): strong: kidney [3] [4], intestine [3] [4] [6] especially mucosa [5]; weak: liver [4]; signals in brain might be unspecific [3] [4] and not reproducible [4] [4] [5] [6] [3].
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FF native ligand is 1,25-dihydroxyvitamin D3 [6];
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IN T01345 RXR-alpha; human, Homo sapiens.
IN T01349 RXR-beta; rat, Rattus norvegicus.
IN T01355 TRAP; human, Homo sapiens.
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MX M00966 V$DR3_Q4.
MX M00444 V$VDR_Q3.
MX M00961 V$VDR_Q6.
MX M03569 V$VDR_Q6_01.
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BS R01187.
BS R03524.
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DR TRANSPATH: MO000021499.
DR EMBL: AF011356; GGAF11356.
DR UniProtKB: O42392;
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RN [1]; RE0000117.
RX PUBMED: 2159384.
RA Schuele R., Umesono K., Mangelsdorf D. J., Bolado J., Pike J. W., Evans R. M.
RT Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene
RL Cell 61:497-504 (1990).
RN [2]; RE0002373.
RX PUBMED: 2835767.
RA Baker A. R., McDonnell D. P., Hughes M., Crisp T. M., Mangelsdorf D. J., Haussler M. R., Pike J. W., Shine J., O'Malley B. W.
RT Cloning and expression of full-length cDNA encoding human vitamin D receptor
RL Proc. Natl. Acad. Sci. USA 85:3294-3298 (1988).
RN [3]; RE0002636.
RX PUBMED: 3029866.
RA McDonnell D. P., Mangelsdorf D. J., Pike J. W., Haussler M. R., O'Malley B. W.
RT Molecular cloning of complementary DNA encoding the avian receptor for vitamin D
RL Science 235:1214-1217 (1987).
RN [4]; RE0016364.
RX PUBMED: 9056239.
RA Lu Z., Hanson K., DeLuca H. F.
RT Cloning and origin of the two forms of chicken vitamin D receptor.
RL Arch. Biochem. Biophys. 339:99-106 (1997).
RN [5]; RE0016374.
RX PUBMED: 6275386.
RA Simpson R. U., DeLuca H. F.
RT Purification of chicken intestinal receptor for 1 alpha, 25-dihydroxyvitamin D3 to apparent homogeneity
RL Proc. Natl. Acad. Sci. USA 79:16-20 (1982).
RN [6]; RE0016376.
RX PUBMED: 7972109.
RA Elaroussi M. A., Prahl J. M., DeLuca H. F.
RT The avian vitamin D receptors: primary structures and their origins
RL Proc. Natl. Acad. Sci. USA 91:11596-11600 (1994).
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//