AC T00994
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ID T00994
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DT 20.12.1993 (created); ewi.
DT 24.06.2015 (updated); msr.
CO Copyright (C), QIAGEN.
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FA COUP-TF1
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SY chicken ovalbumin upstream promoter transcription factor; COUP-TF; COUP-TF1; COUP-TFI; COUPTFA; EAR3; ERBAL3; NR2F1; nuclear receptor subfamily 2, group F, member 1; SVP44; TCFCOUP1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014472 Nr2f1.
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CL C0002; CC (rec); 2.1.3.5.1.
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FF During embryonic development Nkx2.5 T01675 plays a central role in activating the expression of calreticulin. In embryonic hearts Nkx2.5 expression is high, and COUP-TF1 cannot bind to the CRT site 2 in the calreticulin promoter. Down-regulation of Nkx2.5 expression, which occurs as cardiac development progresses and in newborns, permits association between COUP-TF1 and the calreticulin promoter, resulting in repression of the calreticulin gene - Nkx2.5 and COUP-TF1 may play antagonistic roles [3];
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IN T01345 RXR-alpha; human, Homo sapiens.
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MX M00765 V$COUPDR1_Q6.
MX M03542 V$COUPTF1_Q6_01.
MX M01036 V$COUPTF_Q6.
MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00965 V$DR4_Q2.
MX M00967 V$HNF4_Q6.
MX M07280 V$NR1NR2_Q3.
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BS R04591.
BS R68504.
BS R14384.
BS R17087.
BS R21280.
BS R20689.
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DR TRANSPATH: MO000025326.
DR UniProtKB: Q60632; COT1_MOUSE.
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RN [1]; RE0001755.
RX PUBMED: 1584212.
RA Liu Y., Teng C. T.
RT Estrogen response module of the mouse lactoferrin gene contains overlapping chicken ovalbumin up-stream promoter transcription factor and estrogen receptor-binding elements
RL Mol. Endocrinol. 6:355-364 (1992).
RN [2]; RE0024770.
RX PUBMED: 7947324.
RA Jonk L. J., de Jonge M. E., Pals C. E., Wissink S., Vervaart J. M., Schoorlemmer J., Kruijer W.
RT Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.
RL Mech. Dev. 47:81-97 (1994).
RN [3]; RE0025190.
RX PUBMED: 11106640.
RA Guo L., Lynch J., Nakamura K., Fliegel L., Kasahara H., Izumo S., Komuro I., Agellon L. B., Michalak M.
RT COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development.
RL J. Biol. Chem. 276:2797-2801 (2001).
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