AC T01035
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ID T01035
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DT 20.02.1994 (created); ewi.
DT 13.03.2012 (updated); hna.
CO Copyright (C), QIAGEN.
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FA islet1-isoform1
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SY Isl-1; ISL1; ISL1 transcription factor, LIM/homeodomain 1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009791 Isl1.
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CL C0025; LIM-homeo.
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SZ 349 AA; 39.0 kDa (cDNA) (calc.).
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SQ MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFV
SQ RDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEF
SQ ALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEK
SQ TTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRS
SQ IMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQ
SQ SDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
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SC translated from EMBL #S69329
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FT 15 77 
PS50023; LIM_DOMAIN_2.
FT 16 70 
SM00132; lim_4.
FT 17 76 
PF00412; LIM domain.
FT 78 132 
SM00132; lim_4.
FT 78 139 
PS50023; LIM_DOMAIN_2.
FT 79 138 
PF00412; LIM domain.
FT 179 239 
PS50071; HOMEOBOX_2.
FT 181 243 
SM00389; HOX_1.
FT 182 238 
PF00046; Homeobox domain.
FT 182 238 
PS50558; LIM_HOMEODOMAIN.
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SF the LIM domains of Isl-1 most likely contain 4 zinc ions [4];
SF human T01957, rat T01035 and hamster T06086 isl-1 amino acid sequences are 100% identical [5];
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CP insulin-producing pancreatic endocrine cells.
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FF putative islet-specific activator, may synergize with CREB [3];
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IN T00373 HNF-4alpha1; human, Homo sapiens.
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MX M04616 V$ISL1_Q3.
MX M01127 V$ISL1_Q6.
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BS R03915.
BS R38102.
BS R15432.
BS R15435.
BS R15436.
BS R00901.
BS R03914.
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DR TRANSPATH: MO000025358.
DR EMBL: S69329;
DR EMBL: X53258;
DR UniProtKB: P61374-1;
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RN [1]; RE0001808.
RX PUBMED: 1691825.
RA Karlsson O., Thor S., Norberg T., Ohlsson H., Edlund T.
RT Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain
RL Nature 344:879-882 (1990).
RN [2]; RE0002317.
RX PUBMED: 3288987.
RA Ohlsson H., Karlsson O., Edlund T.
RT A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer
RL Proc. Natl. Acad. Sci. USA 85:4228-4231 (1988).
RN [3]; RE0002558.
RX PUBMED: 1352885.
RA Leonard J., Serup P., Gonzalez G., Edlund T., Montminy M.
RT The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells
RL Proc. Natl. Acad. Sci. USA 89:6247-6251 (1992).
RN [4]; RE0004762.
RX PUBMED: 7904068.
RA Archer V. E. V., Breton J., Sanchez-Garcia I., Osada H., Forster A., Thomson A. J., Rabbitts T. H.
RT Cyteine-rich LIM domains of LIM-hoemodomain and LIM-only proteins contain zinc but not iron
RL Proc. Natl. Acad. Sci. USA 91:316-320 (1994).
RN [5]; RE0011957.
RX PUBMED: 7759514.
RA Wang M., Drucker D. J.
RT The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
RL J. Biol. Chem. 270:12646-12652 (1995).
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