AC T01049
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ID T01049
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DT 22.02.1994 (created); ewi.
DT 17.03.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA HNF-3beta
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SY Foxa2; HNF3B; HNF3beta.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001172 Foxa2.
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CL C0023; fork head; 3.3.1.1.2.
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CP liver (intestine, lung, stomach, ovary).
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FF activator;
FF involved in regulation of liver and intestinal gene expression [7];
FF was known as OB2 [8];
FF cell type-specific protein in neuronal cells [8] [9];
FF acts synergistically with USF [8] [9];
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IN T03296 HNF-6; mouse, Mus musculus.
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MX M00131 V$HNF3B_01.
MX M02014 V$HNF3B_Q6.
MX M00791 V$HNF3_Q6.
MX M01012 V$HNF3_Q6_01.
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BS R30817.
BS R05105.
BS R03666.
BS R55816.
BS R66791.
BS R55822.
BS R17149.
BS R17151.
BS R17157.
BS R05104.
BS R05084.
BS R05085.
BS R55814.
BS R55815.
BS R05102.
BS R05101.
BS R16569.
BS R21241.
BS R04324.
BS R25965.
BS R01800.
BS R38143.
BS R38146.
BS R55812.
BS R31605.
BS R08915.
BS R34634.
BS R72313.
BS R72314.
BS R05103.
BS R16547.
BS R21385.
BS R05078.
BS R08137.
BS R08139.
BS R55955.
BS R21128.
BS R02350.
BS R04662.
BS R19525.
BS R02989.
BS R64674.
BS R03150.
BS R05029.
BS R04321.
BS R34641.
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DR TRANSPATH: MO000045363.
DR TRANSCOMPEL: C00037.
DR TRANSCOMPEL: C00277.
DR TRANSCOMPEL: C00627.
DR UniProtKB: P32182;
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RN [1]; RE0000288.
RX PUBMED: 1638120.
RA Sladek F. M., Darnell J. E.
RT Mechanisms of liver-specific gene expression
RL Curr. Opin. Gen. Dev. 2:256-259 (1992).
RN [2]; RE0000676.
RX PUBMED: 2227418.
RA Lai E., Prezioso V. R., Smith E., Litvin O., Costa R. H., Darnell J. E.
RT HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally
RL Genes Dev. 4:1427-1436 (1990).
RN [3]; RE0001695.
RX PUBMED: 1324404.
RA Pani L., Overdier D. G., Porcella A., Qian X., Lai E., Costa R. H.
RT Hepatocyte nuclear factor 3beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein
RL Mol. Cell. Biol. 12:3723-3732 (1992).
RN [4]; RE0003012.
RX PUBMED: 8139574.
RA Overdier D. G., Porcella A., Costa R. H.
RT The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix
RL Mol. Cell. Biol. 14:2755-2766 (1994).
RN [5]; RE0006536.
RX PUBMED: 7739897.
RA Qian X., Costa R. H.
RT Analysis of hepatocyte nuclear factor-3beta protein domains required for transcriptional activation and nuclear targeting
RL Nucleic Acids Res. 23:1184-1191 (1995).
RN [6]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [7]; RE0014471.
RX PUBMED: 8887657.
RA Samadani U., Costa R. H.
RT The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression
RL Mol. Cell. Biol. 16:6273-6284 (1996).
RN [8]; RE0016372.
RX PUBMED: 9218472.
RA Lanigan T. M., Russo A. F.
RT Binding of upstream stimulatory factor and a cell-specific activator to the calcitonin/calcitonin gene-related peptide enhancer.
RL J. Biol. Chem. 272:18316-18324 (1997).
RN [9]; RE0035145.
RX PUBMED: 15385550.
RA Viney T. J., Schmidt T. W., Gierasch W., Sattar A. W., Yaggie R. E., Kuburas A., Quinn J. P., Coulson J. M., Russo A. F.
RT Regulation of the cell-specific calcitonin/calcitonin gene-related peptide enhancer by USF and the Foxa2 forkhead protein.
RL J. Biol. Chem. 279:49948-49955 (2004).
RN [10]; RE0046916.
RX PUBMED: 12509444.
RA Rausa F. M., Tan Y., Costa R. H.
RT Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding
RL Mol. Cell. Biol. 23:437-49 (2003).
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