AC T03296
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ID T03296
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DT 10.05.2000 (created); rio.
DT 14.07.2014 (updated); sup.
CO Copyright (C), QIAGEN.
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FA HNF-6
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SY D9Ertd423e; Hepatocyte nuclear factor 6; Hfh12; HNF6; one cut domain, family member 1; onecut1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006511 Onecut1.
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CL C0006; homeo; 3.1.9.1.1.
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CP (embryonic) pancreas [2].
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FF HNF-6 is essential for normal pancreatic endocrine differentiation in embryonic mice [2];
FF in knock-out mice (hnf6-/-) islands of Langerhans appeared late (after birth) and beta cells were deficient in glucose transporter 2 [2];
FF adult knock-out mice (hnf6-/-) showed perturbed glucose homeostasis (diabetes) [2];
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IN T01049 HNF-3beta; rat, Rattus norvegicus.
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MX M03829 V$HNF6_Q4.
MX M00639 V$HNF6_Q6.
MX M07357 V$HNF6_Q6_01.
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BS R20970.
BS R08894.
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DR TRANSPATH: MO000027234.
DR UniProtKB: O08755;
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RN [1]; RE0014471.
RX PUBMED: 8887657.
RA Samadani U., Costa R. H.
RT The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression
RL Mol. Cell. Biol. 16:6273-6284 (1996).
RN [2]; RE0024512.
RX PUBMED: 10825208.
RA Jacquemin P., Durviaux S. M., Jensen J., Godfraind C., Gradwohl G., Guillemot F., Madsen O. D., Carmeliet P., Dewerchin M., Collen D., Rousseau G. G., Lemaigre F. P.
RT Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.
RL Mol. Cell. Biol. 20:4445-4454 (2000).
RN [3]; RE0046916.
RX PUBMED: 12509444.
RA Rausa F. M., Tan Y., Costa R. H.
RT Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding
RL Mol. Cell. Biol. 23:437-49 (2003).
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