AC T01076
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ID T01076
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DT 24.02.1994 (created); ewi.
CO Copyright (C), QIAGEN.
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FA mec-3
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SY mec-3; mechanosensory protein 3.
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OS Caenorhabditis elegans
OC eukaryota; animalia; metazoa; nematoda; secernentea; rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae
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GE G001804 mec-3.
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CL C0025; LIM-homeo.
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SZ 321 AA; 37.1 kDa (cDNA) (calc.).
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SQ MEMLESKPLSAISMVIDSIGVDHENQNKCNCCNEQIYDRYIYRMDNRSYHENCVKCTICE
SQ SPLAEKCFWKNGRIYCSQHYYKDHSIHRCAGCKKGVSPTDMVYKLKAGLVFHVECHCCSL
SQ CGRHLSPGEQILVDDTMMTVSCMSHYPPQMDDNAPGAIGSAVDIPSCSTENPIAPYPIDE
SQ SFSSAFQVKKEVDAYGYNFEHYSFSDFCDDDSRMLKRRGPRTTIKQNQLDVLNEMFSNTP
SQ KPSKHARAKLALETGLSMRVIQVWFQNRRSKERRLKHLCNYLRHYEQRGLIPPPIHFRNE
SQ EMDTTDFNAFCGNFEEEDDED
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SC Swiss-Prot#P09088
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FT 27 86 
PS50023; LIM_DOMAIN_2.
FT 28 79 
SM00132; lim_4.
FT 29 85 
PF00412; LIM domain.
FT 87 152 
PS50023; LIM_DOMAIN_2.
FT 88 145 
SM00132; lim_4.
FT 89 151 
PF00412; LIM domain.
FT 215 275 
PS50071; HOMEOBOX_2.
FT 217 293 
heterodimerisation region [4].
FT 217 279 
SM00389; HOX_1.
FT 218 274 
PF00046; Homeobox domain.
FT 218 274 PS50558; LIM_HOMEODOMAIN.
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SF mec-3 and unc-86 T01882 bind cooperatively as a heterodimer to the mec-3 promoter with an increase of DNA binding affinity and stability [4] [3];
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CP six touch receptor neurons (AVM, 2x ALM, PVM, 2x PLM) and the FLP and PVD neuron pairs [3].
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FF cell fate of touch receptor cells once the cells have been generated by unc-86 [4];
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IN T01882 unc-86; Caenorhabditis elegans.
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BS R08940.
BS R08941.
BS R08942.
BS R08943.
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DR TRANSPATH: MO000025382.
DR EMBL: L02877;
DR EMBL: M20244;
DR UniProtKB: P09088;
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RN [1]; RE0000775.
RX PUBMED: 1349545.
RA Cohen B., McGuffin E., Pfeifle C., Segal D., Cohen S. M.
RT apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins
RL Genes Dev. 6:715-729 (1992).
RN [2]; RE0004774.
RX PUBMED: 2898300.
RA Way J. C., Chalfie M.
RT Mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans
RL Cell 54:5-16 (1988).
RN [3]; RE0004775.
RX PUBMED: 1361171.
RA Xue D., Finney M., Ruvkun G., Chalfie M.
RT Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3
RL EMBO J. 11:4969-4979 (1992).
RN [4]; RE0014646.
RX PUBMED: 8103239.
RA Xue D., Tu Y., Chalfie M.
RT Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3
RL Science 261:1324-1328 (1993).
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