AC T01882
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ID T01882
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DT 09.08.1996 (created); ewi.
DT 03.03.2005 (updated); elf.
CO Copyright (C), QIAGEN.
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FA unc-86
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OS Caenorhabditis elegans
OC eukaryota; animalia; metazoa; nematoda; secernentea; rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae
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HO POU4F2, POU4F3 (vertebrates).
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CL C0007; POU.
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SZ 467 AA; 52.3 kDa (gene) (calc.).
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SQ MEKAHRFRLPFCSFFPVPLLVSVLIFHHSAPFLIQLFFPSPLFNPLLRPSKISRGSENGA
SQ CTSHSTLQRTRKIIQWELPKRGGDQDIGDPRPFRIHLSPPSFKVPLFSTDMQNTAPVPTT
SQ TTASKMQPFNNSLFGSFDDPILNARAAQVALADIDVKNVPQLTNPLMRPHDMFSYSNYFS
SQ GIHDTSAATNIYQGLPSSSEPFDASVVVPTSSDDQMTPLQQVMAMQQSYGAPPPFQYNMT
SQ HPFSTTSIASSNNLARYPIAPPTSDMDTDPRQLETFAEHFKQRRIKLGVTQADVGKALAH
SQ LKMPGVGSLSQSTICRFESLTLSHNNMVALKPILHSWLEKAEEAMKQKDTIGDINGILPN
SQ TDKKRKRTSIAAPEKRELEQFFKQQPRPSGERIASIADRLDLKKNVVRVWFCNQRQKQKR
SQ DFRSQFRARSAAAVMGPRVMPVLNGNNSNNNLKQGQTTYNGLPGFFD
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SC Swiss-Prot#P13528
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FT 103 422 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 265 342 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 265 342 
SM00352; pou.
FT 361 421 
PS50071; HOMEOBOX_2.
FT 361 423 
PS50550; POU_HOMEODOMAIN.
FT 363 425 
SM00389; HOX_1.
FT 364 420 
PF00046; Homeobox domain.
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SF unc-86 and mec-3 T01076 bind cooperatively as a heterodimer to the mec-3 promoter with an increase of DNA binding affinity and stability [4] [3];
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FF required for specifying neural identities of neuroblast lineage daughter cells [1] [2];
FF appears shortly after division of those cells that require this factor for their further development [2];
FF required in touch cell precursors to generate the touch receptor neurons [4];
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IN T01076 mec-3; Caenorhabditis elegans.
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MX M08057 N$UNC86_01.
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BS R08935.
BS R08936.
BS R08937.
BS R08938.
BS R08939.
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DR TRANSPATH: MO000045822.
DR EMBL: L10990; CEC30A5.
DR EMBL: M22363; CEUNC86A.
DR UniProtKB: P13528; UN86_CAEEL.
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RN [1]; RE0000242.
RX PUBMED: 2903797.
RA Finney M., Ruvkun G., Horvitz H. R.
RT The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors
RL Cell 55:757-769 (1988).
RN [2]; RE0004228.
RX PUBMED: 2257628.
RA Finney M., Ruvkun G.
RT The unc-86 gene product couples cell lineage and cell identity in C. elegans
RL Cell 63:895-905 (1990).
RN [3]; RE0004775.
RX PUBMED: 1361171.
RA Xue D., Finney M., Ruvkun G., Chalfie M.
RT Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3
RL EMBO J. 11:4969-4979 (1992).
RN [4]; RE0014646.
RX PUBMED: 8103239.
RA Xue D., Tu Y., Chalfie M.
RT Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3
RL Science 261:1324-1328 (1993).
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