AC T01109
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ID T01109
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DT 14.03.1994 (created); ewi.
DT 20.11.2007 (updated); pch.
CO Copyright (C), QIAGEN.
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FA TCF-1(P)
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SY T cell factor 1; TCF-1; TCF-1P; TCF-7; TCF7.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G010134 Tcf7.
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CL C0015; HMG.
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SZ 303 AA; 33.6 kDa (cDNA) (calc.).
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SQ MYKETVYSAFNLLMPYPPASGAGQHPQPQPPLHNKPGQPPHGVPQLSPLYEHFSSPHPTP
SQ APADISQKQGVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWPSPPLYPLSPSCGYRQHFPA
SQ PTAAPGAPYPRFTHPSLMLGSGVPGHPAAIPHPAIVPSSGKQELQPYDRNLKTQAEPKAE
SQ KEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYEL
SQ ARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPM
SQ TVL
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SC Swiss-Prot#Q00417-1
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FT 187 257 
SM00398; hmgende2.
FT 188 256 
PF00505; HMG (high mobility group) box.
FT 188 256 
PS50118; HMG_BOX_2.
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SF most similar to human splice variant TCF-1B except a 31 AA insert after residue 88 of the human factor;
SF most abundant isoform lacking an beta-catenin interacting domain [4];
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CP see functional features.
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FF TCF-1P regulation might be regulated by APC and beta-catenin [4];
FF due to the presence of the Groucho interacting domain this isoform can act as a negative regulator of Wnt signalling pathway [4];
FF for expression in teeth, see [5];
FF cell specificity: T cells [2];
FF nucleus of intestine epithelial cells, basal epithelial cells of mammary gland tissue [4];
FF (embr.<10.5) limb buds, neural crest, pharyngeal arches, nasal process;
FF (embr. < 15.5): lung, urogenital system, tooth buds, thymus and choroid plexus, Reichert's membrane, trophectoderm-derived cells, ribs, thoracic prevertebrae, craniofacial structures, adrenal glands, meninges [3];
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IN T02872 beta-catenin; human, Homo sapiens.
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MX M00978 V$LEF1TCF1_Q4.
MX M00805 V$LEF1_Q2.
MX M03857 V$TCF1_Q5.
MX M07433 V$TCF1_Q5_01.
MX M08902 V$TCF7RELATED_Q4.
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BS R02951.
BS R03696.
BS R03697.
BS R03698.
BS R08814.
BS R08815.
BS R02248.
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DR TRANSPATH: MO000025406.
DR EMBL: X61385;
DR UniProtKB: Q00417-1;
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RN [1]; RE0002188.
RX PUBMED: 1945879.
RA Briegel K., Hentsch B., Pfeuffer I., Serfling E.
RT One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter
RL Nucleic Acids Res. 19:5292-5936 (1991).
RN [2]; RE0004343.
RX PUBMED: 1827138.
RA Oosterwegel M., van de Wetering M., Dooijes D., Klomp L., Winoto A., Georgopoulos K., Meijlink F., Clevers H.
RT Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers
RL J. Exp. Med. 173:1133-1142 (1991).
RN [3]; RE0006815.
RX PUBMED: 8223271.
RA Oosterwegel M., van de Wetering M., Timmerman J., Kruisbeek A., Destree O., Meijlink F., Clevers H.
RT Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis
RL Development 118:439-448 (1993).
RN [4]; RE0014033.
RX PUBMED: 10489374.
RA Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
RT Synergy Between Tumor Suppressor APC and the beta-Catenin-Tcf4 Target Tcf1
RL Science 285:1923-1926 (1999).
RN [5]; RE0014812.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/TCF1.htm
RL Internet : (1996).
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