AC T01147
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ID T01147
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DT 17.04.1994 (created); ewi.
DT 20.08.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA SF-1-isoform3
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SY Ad4BP; fushi tarazu factor homolog 1; NR5A1; steroidogenic factor 1; STF-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004502 Nr5a1.
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HO Ftz-F1.
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CL C0002; CC (rec).
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SZ 465 AA; 51.3 kDa (cDNA) (calc.).
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SQ MEMHRIRGSRIGRGRGGEEAALERGGWLSCSAGTWPTNPRTRPGLGTAPCAQTRAIPSQS
SQ PSARADPILLPQADAAGMDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQN
SQ NKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDR
SQ ALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGD
SQ IGAPSLPMSVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPN
SQ VPELILQLLQLEPEEDQVRARIVGCLQEPAKSGSDQPAPFSLLCRMADQTFISIVDWARR
SQ CMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVSGQEVTELVKPLVLHN
SQ PRPLRADSGHPKFQIQGHALARLLCVLGPFEEPQCGMVSGSSYRR
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SC translated from EMBL:D10584
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FT 87 158 
SM00399; c4gold.
FT 87 162 
PS51030; NUCLEAR_REC_DBD_2.
FT 88 163 
PF00105; Zinc finger, C4 type (two domains).
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SF pI = 8.67;
SF mouse SF-1-isoform3 and ELP transcripts arise from the same structural gene by alternative promoter usage and 3' -splicing [2];
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CP (Y1, adrenocortical tumor; MA-10, Leydig tumor, alphaT3-1).
EX pancreas,beta cell of island of Langerhans,,adult; detectable; immunohistochemistry / immunocytochemistry; protein; [5].
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FF can bind to FLAT (220-201) and P (85-67) element of promoter of rat insulin-1-gener [5];
FF regulator of insulin expression in beta-cells of the pancreas [5];
FF belongs to small group of orphan nuclear receptors which bind to DNA as monomers [3];
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IN T04677 DAX1; mouse, Mus musculus.
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MX M03802 V$SF1_Q5.
MX M07267 V$SF1_Q5_01.
MX M00727 V$SF1_Q6.
MX M01132 V$SF1_Q6_01.
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BS R09630.
BS R20692.
BS R73974.
BS R09631.
BS R09632.
BS R09689.
BS R09695.
BS R27897.
BS R09636.
BS R16140.
BS R17087.
BS R17091.
BS R17092.
BS R02343.
BS R33512.
BS R08849.
BS R09548.
BS R09549.
BS R12703.
BS R14701.
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DR TRANSPATH: MO000025441.
DR TRANSCOMPEL: C00213.
DR TRANSCOMPEL: C00214.
DR TRANSCOMPEL: C00215.
DR TRANSCOMPEL: C00217.
DR TRANSCOMPEL: C00218.
DR TRANSCOMPEL: C00220.
DR TRANSCOMPEL: C00221.
DR TRANSCOMPEL: C00222.
DR TRANSCOMPEL: C00223.
DR EMBL: D10584;
DR UniProtKB: P33242;
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RN [1]; RE0000933.
RX PUBMED: 2365694.
RA Rice D. A., Kirkman M. S., Aitken L. D., Mouw A. R., Schimmer B. P., Parker K. L.
RT Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme
RL J. Biol. Chem. 265:11713-11720 (1990).
RN [2]; RE0015334.
RX PUBMED: 8413309.
RA Ikeda Y., Lala D. S., Luo X., Kim E., Moisan M. P., Parker K. L.
RT Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression
RL Mol. Endocrinol. 7:852-860 (1993).
RN [3]; RE0015434.
RX PUBMED: 10913126.
RA Ito M., Achermann J. C., Jameson J. L.
RT A naturally occurring steroidogenic factor-1 mutation exhibits differential binding and activation of target genes
RL J. Biol. Chem. 275:31708-31714 (2000).
RN [4]; RE0015482.
RX PUBMED: 10446911.
RA Tremblay J. J., Viger R. S.
RT Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1
RL Acta Biochim. Pol. 13:1388-1401 (1999).
RN [5]; RE0048139.
RX PUBMED: 7708065.
RA Peers B., Leonard J., Sharma S., Teitelman G., Montminy M. R.
RT Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.
RL Mol. Endocrinol. 8:1798-1806 (1994).
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