AC T04677
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ID T04677
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DT 24.08.2001 (created); mas.
DT 07.11.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA DAX1
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SY AHCH; DAX-1; NR0B1; orphan nuclear receptor DAX-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002779 Nr0b1.
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CL C0002; CC (rec); 2.1.7.0.1.
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SF atypical nuclear receptor without DNA-binding domain [1];
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CP (adult:) adrenal, testis, central nervous system, pituitary, lung, heart, spleen, kidney, thymus [3].
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FF interacts with nuclear receptor corepressor N-CoR;
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IN T04754 LRH-1; mouse, Mus musculus.
IN T08969 nanog; mouse, Mus musculus.
IN T01348 Nur77; mouse, Mus musculus.
IN T09363 Oct3; mouse, Mus musculus.
IN T10890 Oct3; Mammalia.
IN T01147 SF-1-isoform3; mouse, Mus musculus.
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MX M01248 V$DAX1_01.
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BS R25614.
BS R25530.
BS R25532.
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DR TRANSPATH: MO000028500.
DR UniProtKB: Q61066;
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RN [1]; RE0016769.
RX PUBMED: 9566914.
RA Crawford P. A., Dorn C., Sadovsky Y., Milbrandt J.
RT Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
RL Mol. Cell. Biol. 18:2949-2956 (1998).
RN [2]; RE0016771.
RX PUBMED: 8921887.
RA Guo W., Lovell R. S., Zhang Y. H., Huang B. L., Burris T. P., Craigen W. J., McCabe E. R.
RT Ahch, the mouse homologue of DAX1: cloning, characterization and synteny with GyK, the glycerol kinase locus
RL Gene 178:31-34 (1996).
RN [3]; RE0016773.
RX PUBMED: 8756567.
RA Bae D. S., Schaefer M. L., Partan B. W., Muglia L.
RT Characterization of the mouse DAX-1 gene reveals evolutionary conservation of a unique amino-terminal motif and widespread expression in mouse tissue
RL Endocrinology 137:3921-3927 (1996).
RN [4]; RE0035865.
RX PUBMED: 15155786.
RA Song K. H., Park Y. Y., Park K. C., Hong C. Y., Park J. H., Shong M., Lee K., Choi H. S.
RT The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation.
RL Mol. Endocrinol. 18:1929-1940 (2004).
RN [5]; RE0064955.
RX PUBMED: 17299135.
RA Lawson M. A., Tsutsumi R., Zhang H., Talukdar I., Butler B. K., Santos S. J., Mellon P. L., Webster N. J.
RT Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.
RL Mol. Endocrinol. 21:1175-1191 (2007).
RN [6]; RE0068357.
RX PUBMED: 19528230.
RA Sun C., Nakatake Y., Akagi T., Ura H., Matsuda T., Nishiyama A., Koide H., Ko M. S., Niwa H., Yokota T.
RT Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells.
RL Mol. Cell. Biol. 29:4574-4583 (2009).
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