TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01348 XX ID T01348 XX DT 26.10.1994 (created); ewi. DT 16.08.2015 (updated); jmh. CO Copyright (C), QIAGEN. XX FA Nur77 XX SY 3CH77; N10; NR4A1; Nur/77; TR3; TR3 orphan receptor. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001847 Nr4a1. XX CL C0002; CC (rec); XX SF pI 6.72 (calc.); XX CP (3T3). XX FF activator in absence of exogenously added ligand; FF the nur/77 gene is a growth factor immediate early response gene activated by SRF-ELK-1cooperation [5]; FF immediate-early response factor [4]; FF activated by NGF and membrane depolarization [7]; XX IN T04677 DAX1; mouse, Mus musculus. IN T21552 SRC-1; Mammalia. XX MX M01217 V$NUR77_Q5. MX M04622 V$NUR77_Q5_01. MX M07426 V$NUR77_Q5_02. XX BS R23541. BS R73653. BS R65110. BS R28188. BS R57682. BS R29505. BS R67645. BS R67650. BS R67657. BS R67630. BS R67631. BS R67632. BS R67635. BS R67232. BS R65111. BS R42062. BS R57685. BS R29515. BS R28144. BS R03313. BS R28683. XX DR TRANSPATH: MO000023320. DR TRANSCOMPEL: C00469. DR UniProtKB: P12813; XX RN [1]; RE0001741. RX PUBMED: 1645447. RA Hazel T. G., Misra R., Davis I. J., Greenberg M. E., Lau L. F. RT Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment RL Mol. Cell. Biol. 11:3239-3246 (1991). RN [2]; RE0001765. RX PUBMED: 1922099. RA Davis I. J., Hazel T. G., Lau L. F. RT Transcriptional activation by Nur77, a growth factor-inducible member of the steroid hormone receptor superfamily RL Mol. Endocrinol. 5:854-859 (1991). RN [3]; RE0002367. RX PUBMED: 3186734. RA Hazel T. G., Nathans D., Lau L. F. RT A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily RL Proc. Natl. Acad. Sci. USA 85:8444-8448 (1988). RN [4]; RE0008680. RX PUBMED: 8413214. RA Williams G. T., Lau L. F. RT Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses RL Mol. Cell. Biol. 13:6124-6136 (1993). RN [5]; RE0025229. RX PUBMED: 8614640. RA Latinkic B. V., Zeremski M., Lau L. F. RT Elk-1 can recruit SRF to form a ternary complex upon the serum response element. RL Nucleic Acids Res. 24:1345-1351 (1996). RN [6]; RE0025230. RX PUBMED: 2555161. RA Ryseck R. P., Macdonald-Bravo H., Mattei M. G., Ruppert S., Bravo R. RT Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. RL EMBO J. 8:3327-3335 (1989). RN [7]; RE0025235. RX PUBMED: 8473354. RA Yoon J. K., Lau L. F. RT Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells. RL J. Biol. Chem. 268:9148-9155 (1993). RN [8]; RE0064487. RX PUBMED: 17371839. RA Lim S., Luo M., Koh M., Yang M., bin Abdul Kadir M. N., Tan J. H., Ye Z., Wang W., Melamed P. RT Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone. RL Mol. Cell. Biol. 27:4105-4120 (2007). XX //