AC T04754
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ID T04754
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DT 11.09.2001 (created); mas.
DT 22.06.2016 (updated); mom.
CO Copyright (C), QIAGEN.
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FA LRH-1
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SY fetoprotein transcription factor; FTF; liver receptor homolog; liver receptor homologous protein; LRH-1; LRH1; NR5A2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002684 Nr5a2.
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HO Ftz-F1 (Drosophila).
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CL C0002; CC (rec); 2.1.5.0.2.
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SF binds to DNA as monomer (motif PyCAAGGPyCPu) [1];
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CP Pancreas [5].
EX endoderm of foregut,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX endoderm of foregut,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX endoderm of yolk sac,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX epithelial layer of stomach,,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX intestine,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX intestine,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX intestine,,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX intestine,,,Theiler Stage 25; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX intestine,epithelial cell,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX liver,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX liver,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX liver,,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX liver,,,Theiler Stage 25; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX liver,epithelial cell,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX mouse, Mus musculus,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX neural crest of spinal cord,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,,,Theiler Stage 25; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,ductal epithelial cell of pancreas,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,ductal epithelial cell of pancreas,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,ductal epithelial cell of pancreas,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,ductal epithelial cell of pancreas,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,endocrine epithelial cell,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,epithelial cell,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,exocrine acinar epithelial cell,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,exocrine acinar epithelial cell,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,exocrine acinar epithelial cell,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,exocrine acinar epithelial cell,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pancreas,exocrine acinar epithelial cell,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pharyngeal arches,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX rib cartilage condensation,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX stomach,,,Theiler Stage 20; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
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FF activator [2] [4];
FF regulates cholesterol catabolism into bile acids by activation of CYP7A [2];
FF regulates lipid metabolism by activation of CETP gene [4];
FF may act synergistically with LXR-alpha/RXR-alpha [2] [4];
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IN T04677 DAX1; mouse, Mus musculus.
IN T05321 SHP; mouse, Mus musculus.
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MX M01142 V$LRH1_Q5.
MX M02098 V$LRH1_Q5_01.
MX M07360 V$LRH1_Q6.
MX M07118 V$NR5A2_01.
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BS R22990.
BS R57684.
BS R29112.
BS R73707.
BS R29209.
BS R57687.
BS R37732.
BS R26901.
BS R21309.
BS R20844.
BS R20184.
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DR TRANSPATH: MO000028564.
DR UniProtKB: P45448;
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RN [1]; RE0012257.
RX PUBMED: 8668203.
RA Galarneau L., Pare J.-F., Allard D., Hamel D., Levesque L., Tugwood J. D., Green S., Belanger L.
RT The alpha1-fetoptotein is activated by a nuclear receptor of the drosophila FTZ-F1 family
RL Mol. Cell. Biol. 16:3853-3865 (1996).
RN [2]; RE0016208.
RX PUBMED: 11030331.
RA Lu T. T., Makishima M., Repa J. J., Schoonjans K., Kerr T. A., Auwerx J., Mangelsdorf D. J.
RT Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
RL Mol. Cell 6:507-515 (2000).
RN [3]; RE0016881.
RX PUBMED: 10559496.
RA Rausa F. M., Galarneau L., Belanger L., Costa R. H.
RT The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3beta in the developing murine liver, intestine and pancreas
RL Mech. Dev. 89:185-188 (1999).
RN [4]; RE0018136.
RX PUBMED: 11331284.
RA Luo Y., Liang C.-p., Tall A. R.
RT The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor.
RL J. Biol. Chem. 276:24767-24773 (2001).
RN [5]; RE0050707.
RX PUBMED: 12853459.
RA Fayard E., Schoonjans K., Annicotte J. S., Auwerx J.
RT Liver receptor homolog 1 controls the expression of carboxyl ester lipase.
RL J. Biol. Chem. 278:35725-35731 (2003).
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