AC T05321
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ID T05321
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DT 29.10.2002 (created); oke.
DT 18.05.2006 (updated); jag.
CO Copyright (C), QIAGEN.
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FA SHP
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SY NR0B2; short heterodimer partner; SHP-1; small heterodimer partner.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002555 Nr0b2.
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CL C0002; CC (rec); 2.1.7.0.2.
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SF lacks a DNA binding domain, heterodimerizes with other nuclear receptors and represses their function;
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FF repressor;
FF can act as a passive repressor - heterodimerization with other nuclear receptors;
FF can act as an active repressor - interacts with LRH (FTF) on DNA and thus represses transcription [1];
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IN T05394 AhR:arnt-isoform1; human, Homo sapiens.
IN T04754 LRH-1; mouse, Mus musculus.
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DR TRANSPATH: MO000033926.
DR UniProtKB: Q62227;
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RN [1]; RE0016208.
RX PUBMED: 11030331.
RA Lu T. T., Makishima M., Repa J. J., Schoonjans K., Kerr T. A., Auwerx J., Mangelsdorf D. J.
RT Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
RL Mol. Cell 6:507-515 (2000).
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