AC T01315
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ID T01315
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DT 23.10.1994 (created); ewi.
DT 16.07.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA CREMbeta
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SY CREMbeta.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000532 Crem.
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CL C0008; bZIP.
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SZ 245 AA; 27.4 kDa (cDNA) (calc.).
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SQ MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHMQTGQISVPTLAQVATIAE
SQ TDDSADSEVIDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMA
SQ VPTSIYQTSTGQYNEETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQ
SQ QLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDIC
SQ SPKTD
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SC Swiss-Prot#P27699-3
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FT 36 95 
PS50953; KID.
FT 48 88 
PF02173; pKID domain.
FT 84 84 
phosphorylation by PKA [5].
FT 169 226 
SM00338; brlzneu.
FT 169 229 
PF00170; bZIP transcription factor.
FT 171 222 
PS50217; BZIP.
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SF encoded by exons 1 (B), 3 (E), 4 (F), 6 (X), 7 (H), and the 3'-half of exon 8 (Ib) [7];
SF several alternative splice variants [1];
SF binds with higher affinity than CREMalpha to a series of different CREs [5];
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CP mRNA: pituitary gland, brain, kidney, heart [2].
CN not found in testis [2].
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FF repressor, CREB antagonist as dominant negative regulator [1] [5];
FF CREMbeta is upregulated in CREB -/- mice;
FF repressor function is relieved by phosphorylation of Ser-68, presumably by PKA [5];
FF osmotic stimulation of the supraoptic nucleus, induction of CREMbeta (and -alpha) correlates with down-regulation of c-fos [6];
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IN T01315 CREMbeta; mouse, Mus musculus.
IN T01319 ICER; rat, Rattus norvegicus.
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MX M00981 V$CREBATF_Q6.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00917 V$CREB_Q4_01.
MX M01820 V$CREM_Q6.
MX M08803 V$CREM_Q6_01.
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BS R01358.
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DR TRANSPATH: MO000003370.
DR EMBL: M60285;
DR UniProtKB: P27699-3;
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RN [1]; RE0000262.
RX PUBMED: 1847666.
RA Foulkes N. S., Borrelli E., Sassone-Corsi P.
RT CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
RL Cell 64:739-749 (1991).
RN [2]; RE0001912.
RX PUBMED: 1370576.
RA Foulkes N. S., Mellstroem B., Benusiglio E., Sassone-Corsi P.
RT Developmental switch of CREM function during spermatogenesis: from antagonist to activator
RL Nature 355:80-84 (1992).
RN [3]; RE0001915.
RX PUBMED: 8397338.
RA Stehle J. H., Foulkes N. S., Molina C. A., Simonneaux V., Pevet P., Sassone-Corsi P.
RT Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland
RL Nature 365:314-320 (1993).
RN [4]; RE0002563.
RX PUBMED: 8202542.
RA Hummler E., Cole T. J., Blendy J. A., Ganss R., Aguzzi A., Schmid W., Beermann F., Schuetz G.
RT Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors
RL Proc. Natl. Acad. Sci. USA 91:5647-5651 (1994).
RN [5]; RE0003158.
RX PUBMED: 8458330.
RA Laoide B.M., Foulkes N.S., Schlotter F., Sassone-Corsi P.
RT The functional versatility of CREM is determined by its modular structure
RL EMBO J. 12:1179-1191 (1993).
RN [6]; RE0005266.
RX PUBMED: 8386526.
RA Mellstroem B., Naranjo J. R., Foulkes N. S., Lafarga M., Sassone-Corsi P.
RT Transcriptional response to cAMP in brain: specific distribution and induction of CREM antagonists
RL Neuron 10:655-665 (1993).
RN [7]; RE0000035.
RX PUBMED: 6537904.
RA Parker C. S., Topol J.
RT A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity
RL Cell 36:357-369 (1984).
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