AC T01426
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ID T01426
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DT 04.04.1995 (created); ewi.
DT 20.04.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA HOXD8
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SY 4921540P06Rik; Hox-4.3; Hox-5.4; HOX4E (human); Hoxd-8; HOXD8.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014478 Hoxd8.
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HO abd-A (Drosophila).
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CL C0006; homeo.
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SF through direct protein-protein contacts, the N-terminal arm and helix 1 of the homeo domain are responsible for the inhibitory effect of HOXD8 on HOXD9 [6];
SF this effect also requires an effector domain within AA 1-193 [6];
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FF transcriptional activator through multimerized homeo domain consensus binding sequence [6];
FF also antagonizing autoactivation of HOXD9 through a 'HOX cross-talk region' in the HOXD9 promoter [1] [6];
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IN T01755 hoxd9; mouse, Mus musculus.
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MX M01432 V$HOXD8_01.
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DR TRANSPATH: MO000046045.
DR UniProtKB: P23463; HXD8_MOUSE.
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RN [1]; RE0002874.
RX PUBMED: 1756725.
RA Zappavigna V., Renucci A., Izpisua-Belmonte J.-C., Urier G., Peschle C., Duboule D.
RT HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities
RL EMBO J. 10:4177-4187 (1991).
RN [2]; RE0003865.
RX PUBMED: 1348361.
RA Nazarali A., Kim Y., Nirenberg M.
RT Hox-1.11 and Hox-4.9 homeobox genes
RL Proc. Natl. Acad. Sci. USA 89:2883-2887 (1992).
RN [3]; RE0003904.
RX PUBMED: 1683707.
RA Singh G., Kaur S., Stock J. L., Jenkins N. A., Gilbert D. J., Copeland N. G., Potter S. S.
RT Identification of 10 murine homeobox genes
RL Proc. Natl. Acad. Sci. USA 88:10706-10710 (1991).
RN [4]; RE0004064.
RX PUBMED: 1675873.
RA Sadoul R., Featherstone M. S.
RT Sequence analysis of the homeobox containing exon of the murine Hox 4.3 homeogene
RL Biochim. Biophys. Acta 1089:259-261 (1991).
RN [5]; RE0004065.
RX PUBMED: 1982431.
RA Izpisua-Belmonte J. C., Dolle P., Renucci A., Zappavigna V., Falkenstein H., Duboule D.
RT Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene
RL Development 110:733-745 (1990).
RN [6]; RE0004066.
RX PUBMED: 7926763.
RA Zappavigna V., Sartori D., Mavilio F.
RT Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain
RL Genes Dev. 8:732-744 (1994).
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