AC T01755
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ID T01755
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DT 17.04.1996 (created); ewi.
DT 03.03.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA hoxd9
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SY homeo box D9; Hox-4.4; Hox-5.2; Hoxd-9; HOXD9.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014502 Hoxd9.
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HO Abd-B (Drosophila).
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CL C0006; homeo; 3.1.1.8.4.
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SF spatial expression pattern of hoxd9 gene is governed by 5'- and 3'-flanking sequences [4];
SF targeted disruption exhibits anterior homeotic transformation in the lumbar (L3 to L5) and sacral (S2, S4 and Ca1) region of the vertebral column and alterations of the proximal portion of the forelimb [6];
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CP expressed in posterior domains of the developing embryo [1] and in distal domains of the developing limb [2] [1] [2].
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FF transcriptional activator, positive autoregulation is antagonized by HOXD8 T01426 [3];
FF partial functional redundancy between hoxd9 and HOXA9 T01710 [6];
FF specification of the vertebral identity and development of the forelimb stylopod [6];
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IN T01426 HOXD8; mouse, Mus musculus.
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MX M07456 V$HOXA913_Q4.
MX M04374 V$HOXD9_01.
MX M04375 V$HOXD9_02.
MX M04376 V$HOXD9_03.
MX M01834 V$HOXD9_Q2.
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DR TRANSPATH: MO000046062.
DR UniProtKB: P28357; HXD9_MOUSE.
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RN [1]; RE0003859.
RX PUBMED: 2569969.
RA Duboule D., Dolle P.
RT The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
RL EMBO J. 8:1497-1505 (1989).
RN [2]; RE0004062.
RX PUBMED: 2574828.
RA Dolle P., Izpisua-Belmonte J.-C., Falkenstein H., Renucci A., Duboule D.
RT Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation
RL Nature 342:767-772 (1989).
RN [3]; RE0004066.
RX PUBMED: 7926763.
RA Zappavigna V., Sartori D., Mavilio F.
RT Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain
RL Genes Dev. 8:732-744 (1994).
RN [4]; RE0004069.
RX PUBMED: 1348690.
RA Renucci A., Zappavigna V., Zakany J., Izpisua-Belmonte J. C., Buerki K., Duboule D.
RT Comparison of mouse and human HOX 4 complexes defines conserved sequences involved in the regulation of Hox 4.4
RL EMBO J. 11:1459-1468 (1992).
RN [5]; RE0004070.
RX PUBMED: 2569970.
RA Duboule D., Dolle P.
RT Two gene members of the murine HOX 5 complex show regional and cell type specific expression in developing limbs and gonads
RL EMBO J. 8:1507-1515 (1989).
RN [6]; RE0015499.
RX PUBMED: 8625797.
RA Fromental-Ramain C., Warot X., Lakkaraju S., Favier B., Haack H., Birling C., Dierich A., Doll e P., Chambon P.
RT Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning
RL Development 122:461-472 (1996).
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