AC T01710
XX
ID T01710
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DT 06.03.1996 (created); ewi.
DT 11.12.2014 (updated); asv.
CO Copyright (C), QIAGEN.
XX
FA hoxa9
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SY D6a9; homeo box A9; Hox-1.7; Hoxa-9; HOXA9; XhoxB1 (Xenopus).
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014360 Hoxa9.
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HO Abd-B (Drosophila).
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CL C0006; homeo.
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SZ 271 AA; 29.9 kDa (cDNA) (calc.).
XX
SQ MATTGALGNYYVDSFLLGADAADELGAGRYAPGTLGQPPRQAAALAEHPDFSPCSFQSKA
SQ AVFGASWNPVHAAGANAVPAAVYHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSF
SQ AGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAE
SQ NESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVAR
SQ LLNLTERQVKIWFQNRRMKMKKINKDRAKDE
XX
SC translated from EMBL #AB005457
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FT 1 61 
Meis-1 T03388 T03389 interaction domain [3].
FT 1 192 
PF04617; Hox9 activation region.
FT 203 263 
PS50071; HOMEOBOX_2.
FT 205 267 
SM00389; HOX_1.
FT 206 262 
PF00046; Homeobox domain.
XX
SF 96.7 and 85.1% homology to human T01709 and chick T01708 hoxa9 [4];
SF splice variant hoxa9T T04132 lacks the homeo domain [4];
SF targeted disruption exhibits anterior homeotic transformation in the lumbar region (L1 to L5) of the vertebral column [5];
SF interacts physically with Meis-1T03388 T03389 and binds as heterodimer which stabilizes the Meis-1 DNA interaction complex [3];
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CP (embryo 12.5 days:) trunk region, (adult:) kidney, large intestine [4].
CN (adult:) brain, stomach, small intestine, liver, spleen, testis [4].
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FF partial functional redundancy between hoxa9 and HOXD9 T01755 [5];
FF specification of the vertebral identity and development of the forelimb stylopod [5];
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IN T03388 meis1-a; mouse, Mus musculus.
IN T03389 meis1-b; mouse, Mus musculus.
IN T04254 Smad1; mouse, Mus musculus.
IN T05067 Smad4; mouse, Mus musculus.
IN T04236 Smad6; mouse, Mus musculus.
XX
MX M07456 V$HOXA913_Q4.
MX M01351 V$HOXA9_01.
MX M03874 V$HOXA9_Q5.
MX M07457 V$HOXA9_Q5_01.
MX M00420 V$MEIS1AHOXA9_01.
MX M00421 V$MEIS1BHOXA9_02.
XX
BS R09657.
BS R09658.
BS R09659.
BS R09660.
BS R09661.
BS R09662.
BS R09663.
BS R09664.
BS R09665.
BS R09666.
BS R09667.
BS R09668.
BS R09669.
BS R09670.
BS R09671.
BS R09672.
BS R09673.
BS R09674.
BS R09675.
BS R09676.
BS R09677.
BS R09678.
BS R09679.
BS R09680.
BS R09681.
BS R09682.
BS R09683.
BS R18935.
XX
DR TRANSPATH: MO000025886.
DR EMBL: AB005457;
DR EMBL: AB008914;
DR EMBL: M28449;
DR UniProtKB: P09631-1;
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RN [1]; RE0003895.
RX PUBMED: 2574852.
RA Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.
RT The human HOX gene family
RL Nucleic Acids Res. 17:10385-10402 (1989).
RN [2]; RE0003897.
RX PUBMED: 2891029.
RA Rubin M. R., King W., Toth L. E., Sawczuk I. S., Levine M. S., D'Eustachio P., Nguyen-Huu C. M.
RT Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression (revision)
RL Mol. Cell. Biol. 8:5593-5593 (1988).
RN [3]; RE0015480.
RX PUBMED: 9343407.
RA Shen W. F., Montgomery J. C., Rozenfeld S., Moskow J. J., Lawrence H. J., Buchberg A. M., Largman C.
RT AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins
RL Mol. Cell. Biol. 17:6448-6458 (1997).
RN [4]; RE0015498.
RX PUBMED: 9524228.
RA Fujimoto S., Araki K., Chisaka O., Araki M., Takagi K., Yamamura K.
RT Analysis of the murine Hoxa-9 cDNA: an alternatively spliced transcript encodes a truncated protein lacking the homeodomain
RL Gene 209:77-85 (1998).
RN [5]; RE0015499.
RX PUBMED: 8625797.
RA Fromental-Ramain C., Warot X., Lakkaraju S., Favier B., Haack H., Birling C., Dierich A., Doll e P., Chambon P.
RT Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning
RL Development 122:461-472 (1996).
XX
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