AC T03389
XX
ID T03389
XX
DT 26.05.2000 (created); rio.
DT 29.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
XX
FA meis1-b
XX
SY Meis1; myeloid ecotropic viral integration site 1b.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G014347 Meis1.
XX
HO Pbx (vertebrates), Exd (Drosophila).
XX
CL C0006; homeo; 3.1.4.2.1.2.
XX
SZ 465 AA; 50.8 kDa (cDNA) (calc.).
XX
SQ MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA
SQ PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED
SQ IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK
SQ MPIDLVIDDREGGSKSDSEDVTRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHS
SQ GDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYP
SQ SEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVM
SQ DGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQAQMPPHPAQLRHGPPMHTYIPG
SQ HPHHPAVMMHGGQPHPGMPMSASSPSVLNTGDPTMSAQVMDIHAQ
XX
SC translated from EMBL #U33630
XX
FT 71 100 
HR1 domain [5].
FT 87 465 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 135 180 
HR2 domain [5].
FT 270 333 
PS50071; HOMEOBOX_2.
FT 272 337 
SM00389; HOX_1.
FT 273 332 
PF00046; Homeobox domain.
XX
SF TALE (three amino acid loop extension) homeo domain superclass [2];
SF Pbx related homeo domain [1];
SF Mais-1 may represent a novel proto-oncogene [1];
SF forms cooperative binding complexes with AbdB-like HOX proteins HOXA9 T01710, HOXA10 T01715, HOXA11 T01717, HOXD12 T01763, HOXB13 T03802 and stabilizes the DNA interaction complex [4];
SF interacts physically with HOXA9 T01710 and binds as heterodimer [4];
SF N-terminal region (HR1 and HR2) shares homology with PKNOX1 T04121 and mediates binding to Pbx-1 [5];
XX
CP (embryo:) expressed at high levels from 7-17 days [3]; (adult:) heart, brain, lung, spleen [1] [3]; BXH-2 tumors [1] [1] [3].
CN (adult:) liver, skeletal muscle, kidney [3].
XX
FF altered expression of Meis-1 may lead to tumor formation in BXH-2 mice [1];
XX
IN T01715 HOXA10; mouse, Mus musculus.
IN T01717 HOXA11; mouse, Mus musculus.
IN T03337 HOXA13; mouse, Mus musculus.
IN T13907 HoxA2; mouse, Mus musculus.
IN T00377 HOXA5; mouse, Mus musculus.
IN T01710 hoxa9; mouse, Mus musculus.
IN T14354 hoxa9; mouse, Mus musculus.
IN T03802 HOXB13; mouse, Mus musculus.
IN T01728 HOXB4; mouse, Mus musculus.
IN T01737 HOXB8; mouse, Mus musculus.
IN T03354 HOXC13; mouse, Mus musculus.
IN T01763 HOXD12; mouse, Mus musculus.
IN T01765 HOXD13; mouse, Mus musculus.
XX
MX M00420 V$MEIS1AHOXA9_01.
MX M00421 V$MEIS1BHOXA9_02.
MX M00419 V$MEIS1_01.
MX M01419 V$MEIS1_02.
XX
BS R09670.
BS R09671.
BS R09672.
BS R09673.
BS R09674.
BS R09675.
BS R09676.
BS R09677.
BS R09678.
BS R09679.
BS R09680.
BS R09681.
BS R09682.
BS R09683.
BS R09637.
BS R09638.
BS R09639.
BS R09640.
BS R09641.
BS R09642.
BS R09643.
BS R09644.
BS R09645.
BS R09646.
BS R09647.
BS R09648.
BS R09649.
BS R09650.
BS R09651.
BS R09652.
BS R09653.
BS R09654.
BS R09655.
BS R09656.
XX
DR TRANSPATH: MO000027326.
DR EMBL: U33630;
DR UniProtKB: Q60954-2;
XX
RN [1]; RE0010659.
RX PUBMED: 7565694.
RA Moskow J. J., Bullrich F., Huebner K., Daar I. O., Buchberg A. M.
RT Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice
RL Mol. Cell. Biol. 15:5434-5443 (1995).
RN [2]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [3]; RE0014560.
RX PUBMED: 8950991.
RA Nakamura T., Jenkins N. A., Copeland N. G.
RT Identification of a new family of Pbx-related homeobox genes
RL Oncogene 13:2235-2242 (1996).
RN [4]; RE0015480.
RX PUBMED: 9343407.
RA Shen W. F., Montgomery J. C., Rozenfeld S., Moskow J. J., Lawrence H. J., Buchberg A. M., Largman C.
RT AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins
RL Mol. Cell. Biol. 17:6448-6458 (1997).
RN [5]; RE0015494.
RX PUBMED: 10381567.
RA Ferretti E., Schulz H., Talarico D., Blasi F., Berthelsen J.
RT The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
RL Mech. Dev. 83:53-64 (1999).
RN [6]; RE0064941.
RX PUBMED: 15617687.
RA Williams T. M., Williams M. E., Innis J. W.
RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
RL Dev. Biol. 277:457-471 (2005).
XX
//