TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01717 XX ID T01717 XX DT 07.03.1996 (created); ewi. DT 03.03.2014 (updated); jtr. CO Copyright (C), QIAGEN. XX FA HOXA11 XX SY Hox-1.9; HOX1I (human); Hoxa-11. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014496 Hoxa11. XX HO Abd-B (Drosophila). XX CL C0006; homeo; XX SF several antisense transcripts have been detected, that are complementary expressed to the sense transcript in the limb buds [4]; SF male and female homozygous mutant mice are sterile [4]; SF binds cooperatively with Meis-1T03388 T03389 and stabilizes the DNA interaction complex [5]; XX CP (embryonic) forelimb and hindlimb, urogenital tract, metanephric kidney, glan penis, skin epithelium, foregut, stomach; (adult) vas deferens. CN (embryonal) primitive tubules, glomerulus, gonads. XX FF involved in developmental regulation of appendicular and axial body regions [2]; FF mutants reveal homeotic transformation of the 13th thoracic vertebra to an additional lumbar one [2]; FF anteriorization of the sacral region leads to another lumbar vertebra [2]; FF forelimbs and hindlimbs show malformations [2]; FF required for development of radius and ulna as well as for normal kidney development (together with HoxD11) [3]; XX IN T03388 meis1-a; mouse, Mus musculus. IN T03389 meis1-b; mouse, Mus musculus. XX MX M01378 V$HOXA11_01. MX M04366 V$HOXA11_03. MX M04367 V$HOXA11_04. XX DR TRANSPATH: MO000046051. DR UniProtKB: P31311; HXAB_MOUSE. XX RN [1]; RE0003904. RX PUBMED: 1683707. RA Singh G., Kaur S., Stock J. L., Jenkins N. A., Gilbert D. J., Copeland N. G., Potter S. S. RT Identification of 10 murine homeobox genes RL Proc. Natl. Acad. Sci. USA 88:10706-10710 (1991). RN [2]; RE0003908. RX PUBMED: 7902826. RA Small K. M., Potter S. S. RT Homeotic transformations and limb defects in HOX A11 mutant mice RL Genes Dev. 7:2318-2328 (1993). RN [3]; RE0006760. RX PUBMED: 7596412. RA Davis A. P., Witte D. P., Hsieh-Li H. M., Potter S. S., Capecchi M. R. RT Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11 RL Nature 375:791-795 (1995). RN [4]; RE0006822. RX PUBMED: 7789268. RA Hsieh-Li H. M., Witte D. P., Weinstein M., Branford W., Li H., Small K., Potter S. S. RT Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility RL Development 121:1373-1385 (1995). RN [5]; RE0015480. RX PUBMED: 9343407. RA Shen W. F., Montgomery J. C., Rozenfeld S., Moskow J. J., Lawrence H. J., Buchberg A. M., Largman C. RT AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins RL Mol. Cell. Biol. 17:6448-6458 (1997). RN [6]; RE0064941. RX PUBMED: 15617687. RA Williams T. M., Williams M. E., Innis J. W. RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. RL Dev. Biol. 277:457-471 (2005). XX //