AC T03388
XX
ID T03388
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DT 26.05.2000 (created); rio.
DT 29.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA meis1-a
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SY Meis1; myeloid ecotropic viral integration site 1a.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014347 Meis1.
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HO Pbx (vertebrates), Exd (Drosophila).
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CL C0006; homeo; 3.1.4.2.1.1.
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SZ 390 AA; 43.0 kDa (cDNA) (calc.).
XX
SQ MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA
SQ PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED
SQ IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK
SQ MPIDLVIDDREGGSKSDSEDVTRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHS
SQ GDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYP
SQ SEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVM
SQ DGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
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SC translated from EMBL #U33629
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FT 1 348 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 71 100 
HR1 domain [5].
FT 135 180 
HR2 domain [5].
FT 270 333 
PS50071; HOMEOBOX_2.
FT 272 337 
SM00389; HOX_1.
FT 273 332 
PF00046; Homeobox domain.
XX
SF TALE (three amino acid loop extension) homeo domain superclass [2];
SF Pbx related homeo domain [1];
SF Mais-1 may represent a novel proto-oncogene [1];
SF forms cooperative binding complexes with AbdB-like HOX proteins and stabilizes the DNA interaction complex [4];
SF interacts physically with HOXA9 T01710 and binds as heterodimer [4];
SF N-terminal region (HR1 and HR2) shares homology with PKNOX1 T04121 and mediates binding to Pbx-1 T01481 T02087 [5] [6];
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CP (embryo:) expressed at high levels from 7-17 days [3]; (adult:) heart, brain, lung, spleen [1] [3]; BXH-2 tumors [1] [1] [3].
CN (adult:) liver, skeletal muscle, kidney [3].
XX
FF altered expression of Meis-1 may lead to tumor formation in BXH-2 mice [1];
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IN T01715 HOXA10; mouse, Mus musculus.
IN T01717 HOXA11; mouse, Mus musculus.
IN T03337 HOXA13; mouse, Mus musculus.
IN T13907 HoxA2; mouse, Mus musculus.
IN T00377 HOXA5; mouse, Mus musculus.
IN T01710 hoxa9; mouse, Mus musculus.
IN T14354 hoxa9; mouse, Mus musculus.
IN T03802 HOXB13; mouse, Mus musculus.
IN T01728 HOXB4; mouse, Mus musculus.
IN T01737 HOXB8; mouse, Mus musculus.
IN T03354 HOXC13; mouse, Mus musculus.
IN T01763 HOXD12; mouse, Mus musculus.
IN T01765 HOXD13; mouse, Mus musculus.
IN T09093 ipf1; mouse, Mus musculus.
IN T02088 Pbx1b; mouse, Mus musculus.
IN T31817 Pbx1b; Mammalia.
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MX M00420 V$MEIS1AHOXA9_01.
MX M00421 V$MEIS1BHOXA9_02.
MX M00419 V$MEIS1_01.
MX M01419 V$MEIS1_02.
XX
BS R09657.
BS R09658.
BS R09659.
BS R09660.
BS R09661.
BS R09662.
BS R09663.
BS R09664.
BS R09665.
BS R09666.
BS R09667.
BS R09668.
BS R09669.
BS R09637.
BS R09638.
BS R09639.
BS R09640.
BS R09641.
BS R09642.
BS R09643.
BS R09644.
BS R09645.
BS R09646.
BS R09647.
BS R09648.
BS R09649.
BS R09650.
BS R09651.
BS R09652.
BS R09653.
BS R09654.
BS R09655.
BS R09656.
BS R09696.
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DR TRANSPATH: MO000027325.
DR EMBL: U33629;
DR UniProtKB: Q60954-1;
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RN [1]; RE0010659.
RX PUBMED: 7565694.
RA Moskow J. J., Bullrich F., Huebner K., Daar I. O., Buchberg A. M.
RT Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice
RL Mol. Cell. Biol. 15:5434-5443 (1995).
RN [2]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [3]; RE0014560.
RX PUBMED: 8950991.
RA Nakamura T., Jenkins N. A., Copeland N. G.
RT Identification of a new family of Pbx-related homeobox genes
RL Oncogene 13:2235-2242 (1996).
RN [4]; RE0015480.
RX PUBMED: 9343407.
RA Shen W. F., Montgomery J. C., Rozenfeld S., Moskow J. J., Lawrence H. J., Buchberg A. M., Largman C.
RT AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins
RL Mol. Cell. Biol. 17:6448-6458 (1997).
RN [5]; RE0015494.
RX PUBMED: 10381567.
RA Ferretti E., Schulz H., Talarico D., Blasi F., Berthelsen J.
RT The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
RL Mech. Dev. 83:53-64 (1999).
RN [6]; RE0015495.
RX PUBMED: 9405651.
RA Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P.
RT Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
RL Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997).
RN [7]; RE0064941.
RX PUBMED: 15617687.
RA Williams T. M., Williams M. E., Innis J. W.
RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
RL Dev. Biol. 277:457-471 (2005).
RN [8]; RE0065060.
RX PUBMED: 9315626.
RA Chang C. P., Jacobs Y., Nakamura T., Jenkins N. A., Copeland N. G., Cleary M. L.
RT Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.
RL Mol. Cell. Biol. 17:5679-5687 (1997).
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