TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T03388 XX ID T03388 XX DT 26.05.2000 (created); rio. DT 29.04.2010 (updated); jig. CO Copyright (C), QIAGEN. XX FA meis1-a XX SY Meis1; myeloid ecotropic viral integration site 1a. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014347 Meis1. XX HO Pbx (vertebrates), Exd (Drosophila). XX CL C0006; homeo; XX SZ 390 AA; 43.0 kDa (cDNA) (calc.). XX SQ MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA SQ PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED SQ IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK SQ MPIDLVIDDREGGSKSDSEDVTRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHS SQ GDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYP SQ SEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVM SQ DGQQHMGIRAPGPMSGMGMNMGMEGQWHYM XX SC translated from EMBL #U33629 XX FT 1 348 PF00478; IMP dehydrogenase / GMP reductase domain. FT 71 100 HR1 domain [5]. FT 135 180 HR2 domain [5]. FT 270 333 PS50071; HOMEOBOX_2. FT 272 337 SM00389; HOX_1. FT 273 332 PF00046; Homeobox domain. XX SF TALE (three amino acid loop extension) homeo domain superclass [2]; SF Pbx related homeo domain [1]; SF Mais-1 may represent a novel proto-oncogene [1]; SF forms cooperative binding complexes with AbdB-like HOX proteins and stabilizes the DNA interaction complex [4]; SF interacts physically with HOXA9 T01710 and binds as heterodimer [4]; SF N-terminal region (HR1 and HR2) shares homology with PKNOX1 T04121 and mediates binding to Pbx-1 T01481 T02087 [5] [6]; XX CP (embryo:) expressed at high levels from 7-17 days [3]; (adult:) heart, brain, lung, spleen [1] [3]; BXH-2 tumors [1] [1] [3]. CN (adult:) liver, skeletal muscle, kidney [3]. XX FF altered expression of Meis-1 may lead to tumor formation in BXH-2 mice [1]; XX IN T01715 HOXA10; mouse, Mus musculus. IN T01717 HOXA11; mouse, Mus musculus. IN T03337 HOXA13; mouse, Mus musculus. IN T13907 HoxA2; mouse, Mus musculus. IN T00377 HOXA5; mouse, Mus musculus. IN T01710 hoxa9; mouse, Mus musculus. IN T14354 hoxa9; mouse, Mus musculus. IN T03802 HOXB13; mouse, Mus musculus. IN T01728 HOXB4; mouse, Mus musculus. IN T01737 HOXB8; mouse, Mus musculus. IN T03354 HOXC13; mouse, Mus musculus. IN T01763 HOXD12; mouse, Mus musculus. IN T01765 HOXD13; mouse, Mus musculus. IN T09093 ipf1; mouse, Mus musculus. IN T02088 Pbx1b; mouse, Mus musculus. IN T31817 Pbx1b; Mammalia. XX MX M00420 V$MEIS1AHOXA9_01. MX M00421 V$MEIS1BHOXA9_02. MX M00419 V$MEIS1_01. MX M01419 V$MEIS1_02. XX BS R09657. BS R09658. BS R09659. BS R09660. BS R09661. BS R09662. BS R09663. BS R09664. BS R09665. BS R09666. BS R09667. BS R09668. BS R09669. BS R09637. BS R09638. BS R09639. BS R09640. BS R09641. BS R09642. BS R09643. BS R09644. BS R09645. BS R09646. BS R09647. BS R09648. BS R09649. BS R09650. BS R09651. BS R09652. BS R09653. BS R09654. BS R09655. BS R09656. BS R09696. XX DR TRANSPATH: MO000027325. DR EMBL: U33629; DR UniProtKB: Q60954-1; XX RN [1]; RE0010659. RX PUBMED: 7565694. RA Moskow J. J., Bullrich F., Huebner K., Daar I. O., Buchberg A. M. RT Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice RL Mol. Cell. Biol. 15:5434-5443 (1995). RN [2]; RE0014544. RX PUBMED: 9336443. RA Burglin T. R. RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals RL Nucleic Acids Res. 25:4173-4180 (1997). RN [3]; RE0014560. RX PUBMED: 8950991. RA Nakamura T., Jenkins N. A., Copeland N. G. RT Identification of a new family of Pbx-related homeobox genes RL Oncogene 13:2235-2242 (1996). RN [4]; RE0015480. RX PUBMED: 9343407. RA Shen W. F., Montgomery J. C., Rozenfeld S., Moskow J. J., Lawrence H. J., Buchberg A. M., Largman C. RT AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins RL Mol. Cell. Biol. 17:6448-6458 (1997). RN [5]; RE0015494. RX PUBMED: 10381567. RA Ferretti E., Schulz H., Talarico D., Blasi F., Berthelsen J. RT The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse RL Mech. Dev. 83:53-64 (1999). RN [6]; RE0015495. RX PUBMED: 9405651. RA Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P. RT Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 RL Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997). RN [7]; RE0064941. RX PUBMED: 15617687. RA Williams T. M., Williams M. E., Innis J. W. RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. RL Dev. Biol. 277:457-471 (2005). RN [8]; RE0065060. RX PUBMED: 9315626. RA Chang C. P., Jacobs Y., Nakamura T., Jenkins N. A., Copeland N. G., Cleary M. L. RT Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. RL Mol. Cell. Biol. 17:5679-5687 (1997). XX //