AC T01737
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ID T01737
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DT 12.03.1996 (created); ewi.
DT 03.03.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA HOXB8
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SY c1 (human); homeo box B8; Hox-2.4; HOX2D (human); Hoxb-8; HOXB8; XlHbox7 (Xenopus).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014500 Hoxb8.
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HO abd-A (Drosophila).
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CL C0006; homeo; 3.1.1.7.1.
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FF involved in establishing the zone of polarizing activity (ZPA): ectopic expression extending the expression domain to more anterior regions causes formation of a second ZPA and a mirror-image forelimb duplication [1];
FF blocks activation of cell adhesion molecule genes (N-CAM) by HOXB9 [6];
FF proviral insertion at the HOXB8 gene may cause activation and leukemic transformation due to self-renewal of immature myeloid progenitors growing IL-3 independently [3] [5];
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IN T03388 meis1-a; mouse, Mus musculus.
IN T03389 meis1-b; mouse, Mus musculus.
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MX M01451 V$HOXB8_01.
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DR TRANSPATH: MO000046056.
DR UniProtKB: P09632; HXB8_MOUSE.
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RN [1]; RE0003912.
RX PUBMED: 7915198.
RA Charite J., de Graaff W., Shen S., Deschamps J.
RT Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
RL Cell 78:589-601 (1994).
RN [2]; RE0003959.
RX PUBMED: 2891608.
RA Hart C. P., Fainsod A., Ruddle F. H.
RT Sequence analysis of the murine Hox 2.2, 2.3, and 2.4 homeo boxes: Evolutionary and structural comparisons
RL Genomics 1:182-195 (1987).
RN [3]; RE0003972.
RX PUBMED: 2564662.
RA Kongsuwan K., Allen J., Adams J. M.
RT Expression of hox 2.4 homeobox gene induced by proviral insertion in myeloid leukemia
RL Nucleic Acids Res. 17:1881-1892 (1989).
RN [4]; RE0003973.
RX PUBMED: 2907477.
RA Blatt C., Aberdam D., Schwartz R., Sachs L.
RT DNA rearrangement of a homeobox gene in myeloid leukaemic cells
RL EMBO J. 7:4283-4290 (1988).
RN [5]; RE0003974.
RX PUBMED: 1673811.
RA Ben-David L., Aberdam D., Sachs L., Blatt C.
RT A deletion and a rearrangement distinguish between the intracisternal A particle of Hox 2.4 and that of interleukin 3 in the same leukemic cells
RL Virology 182:382-387 (1991).
RN [6]; RE0003975.
RX PUBMED: 1347944.
RA Jones F. S., Prediger E. A., Bittner D. A., de Robertis E. M., Edelman G. M.
RT Cell adhesion molecules as targets for Hox genes: Neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4
RL Proc. Natl. Acad. Sci. USA 89:2086-2090 (1992).
RN [7]; RE0003976.
RX PUBMED: 8104786.
RA Perkins A. C., Cory S.
RT Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene
RL EMBO J. 12:3835-3846 (1993).
RN [8]; RE0064941.
RX PUBMED: 15617687.
RA Williams T. M., Williams M. E., Innis J. W.
RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
RL Dev. Biol. 277:457-471 (2005).
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