TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01737 XX ID T01737 XX DT 12.03.1996 (created); ewi. DT 03.03.2014 (updated); jtr. CO Copyright (C), QIAGEN. XX FA HOXB8 XX SY c1 (human); homeo box B8; Hox-2.4; HOX2D (human); Hoxb-8; HOXB8; XlHbox7 (Xenopus). XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014500 Hoxb8. XX HO abd-A (Drosophila). XX CL C0006; homeo; XX FF involved in establishing the zone of polarizing activity (ZPA): ectopic expression extending the expression domain to more anterior regions causes formation of a second ZPA and a mirror-image forelimb duplication [1]; FF blocks activation of cell adhesion molecule genes (N-CAM) by HOXB9 [6]; FF proviral insertion at the HOXB8 gene may cause activation and leukemic transformation due to self-renewal of immature myeloid progenitors growing IL-3 independently [3] [5]; XX IN T03388 meis1-a; mouse, Mus musculus. IN T03389 meis1-b; mouse, Mus musculus. XX MX M01451 V$HOXB8_01. XX DR TRANSPATH: MO000046056. DR UniProtKB: P09632; HXB8_MOUSE. XX RN [1]; RE0003912. RX PUBMED: 7915198. RA Charite J., de Graaff W., Shen S., Deschamps J. RT Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures RL Cell 78:589-601 (1994). RN [2]; RE0003959. RX PUBMED: 2891608. RA Hart C. P., Fainsod A., Ruddle F. H. RT Sequence analysis of the murine Hox 2.2, 2.3, and 2.4 homeo boxes: Evolutionary and structural comparisons RL Genomics 1:182-195 (1987). RN [3]; RE0003972. RX PUBMED: 2564662. RA Kongsuwan K., Allen J., Adams J. M. RT Expression of hox 2.4 homeobox gene induced by proviral insertion in myeloid leukemia RL Nucleic Acids Res. 17:1881-1892 (1989). RN [4]; RE0003973. RX PUBMED: 2907477. RA Blatt C., Aberdam D., Schwartz R., Sachs L. RT DNA rearrangement of a homeobox gene in myeloid leukaemic cells RL EMBO J. 7:4283-4290 (1988). RN [5]; RE0003974. RX PUBMED: 1673811. RA Ben-David L., Aberdam D., Sachs L., Blatt C. RT A deletion and a rearrangement distinguish between the intracisternal A particle of Hox 2.4 and that of interleukin 3 in the same leukemic cells RL Virology 182:382-387 (1991). RN [6]; RE0003975. RX PUBMED: 1347944. RA Jones F. S., Prediger E. A., Bittner D. A., de Robertis E. M., Edelman G. M. RT Cell adhesion molecules as targets for Hox genes: Neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4 RL Proc. Natl. Acad. Sci. USA 89:2086-2090 (1992). RN [7]; RE0003976. RX PUBMED: 8104786. RA Perkins A. C., Cory S. RT Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene RL EMBO J. 12:3835-3846 (1993). RN [8]; RE0064941. RX PUBMED: 15617687. RA Williams T. M., Williams M. E., Innis J. W. RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. RL Dev. Biol. 277:457-471 (2005). XX //