AC T02088
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ID T02088
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DT 29.01.1997 (created); ewi.
DT 29.04.2011 (updated); lat.
CO Copyright (C), QIAGEN.
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FA Pbx1b
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SY PBX1; pre B-cell leukemia transcription factor 1b.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002136 Pbx1.
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HO Exd (Drosophila), MATa1 (yeast), ceh-20 (C. elegans).
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CL C0006; homeo; 3.1.4.4.1.2.
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SZ 347 AA; 38.4 kDa (cDNA) (calc.).
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SQ MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE
SQ AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP
SQ EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM
SQ NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF
SQ NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
SQ EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGGYPSPCYQPDRRIQ
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SC edited Swiss-Prot #P41778
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FT 33 232 
PF03792; PBX domain.
FT 37 89 
Meis-1 cooperativity domain [5].
FT 231 294 
PS50071; HOMEOBOX_2.
FT 233 298 
SM00389; HOX_1.
FT 234 293 
PF00046; Homeobox domain.
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SF TALE (three amino acid loop extension) homeo domain superclass [3];
SF tissue specific cooperative binding with PKNOX1 T04121 [4];
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CP widespread [2].
CN lymphoid cells [2].
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IN T01720 HOXB1; mouse, Mus musculus.
IN T03388 meis1-a; mouse, Mus musculus.
IN T00545 POU2F1; human, Homo sapiens.
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MX M00096 V$PBX1_01.
MX M00124 V$PBX1_02.
MX M01357 V$PBX1_04.
MX M07451 V$PBX1_10.
MX M02028 V$PBX1_Q3.
MX M00998 V$PBX_Q3.
MX M07304 V$PBX_Q5.
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BS R04429.
BS R35085.
BS R35086.
BS R08497.
BS R19539.
BS R35078.
BS R14770.
BS R14768.
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DR TRANSPATH: MO000010773.
DR EMBL: L27453;
DR UniProtKB: P41778-2;
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RN [1]; RE0005177.
RX PUBMED: 7913464.
RA Kagawa N., Ogo A., Takahashi Y., Iwamatsu A., Waterman M. R.
RT A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1
RL J. Biol. Chem. 269:18716-18719 (1994).
RN [2]; RE0005181.
RX PUBMED: 1682799.
RA Monica K., Saltman D., Nourse J., Galili N., Cleary M. L.
RT PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1
RL Mol. Cell. Biol. 11:6149-6157 (1991).
RN [3]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [4]; RE0015494.
RX PUBMED: 10381567.
RA Ferretti E., Schulz H., Talarico D., Blasi F., Berthelsen J.
RT The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
RL Mech. Dev. 83:53-64 (1999).
RN [5]; RE0015495.
RX PUBMED: 9405651.
RA Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P.
RT Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
RL Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997).
RN [6]; RE0047951.
RX PUBMED: 15138251.
RA Rave-Harel N., Givens M. L., Nelson S. B., Duong H. A., Coss D., Clark M. E., Hall S. B., Kamps M. P., Mellon P. L.
RT TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.
RL J. Biol. Chem. 279:30287-30297 (2004).
RN [7]; RE0065060.
RX PUBMED: 9315626.
RA Chang C. P., Jacobs Y., Nakamura T., Jenkins N. A., Copeland N. G., Cleary M. L.
RT Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.
RL Mol. Cell. Biol. 17:5679-5687 (1997).
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