AC T01720
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ID T01720
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DT 08.03.1996 (created); ewi.
DT 03.03.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA HOXB1
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SY Hox-2.9.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002142 Hoxb1.
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HO Lab (Drosophila) T02064.
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CL C0006; homeo; 3.1.1.1.2.
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SF CD spectroscopy revealed an alpha-helix content of about 71% [1];
SF relatively high affinity to a homeo domain consensus sequence: KD = 2.6 nM [1];
SF interaction with Pbx-1 T03451 T02088 [9] [10];
SF cooperative binding with Exd T01482 [8];
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CP specifically expressed in rhombomere r4 of the developing hindbrain, apparently delimited by Krox-20 T00454 expression in r3 and r5 [2].
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FF HOXB1 expression and rhombomere identity remain unaltered after transplantation to another region of the hindbrain [7];
FF highly sensitive towards retinoic acid (RA)-induction [6];
FF HOXB1 in conjunction with Pbx-1 T03451 T02088 can activate rhombomere-specific expression of Eph (ephrin) receptors [9];
FF HOXB1 is able to activate its own expression (autoregulation) [8];
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IN T03451 Pbx1a; mouse, Mus musculus.
IN T02088 Pbx1b; mouse, Mus musculus.
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BS R32602.
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DR TRANSPATH: MO000025894.
DR UniProtKB: P17919;
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RN [1]; RE0003885.
RX PUBMED: 7911971.
RA Pellerin I., Schnabel C., Catron K. M., Abate C.
RT Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
RL Mol. Cell. Biol. 14:4532-4545 (1994).
RN [2]; RE0003916.
RX PUBMED: 2571936.
RA Wilkinson D. G., Bhatt S., Cook M., Boncinelli E., Krumlauf R.
RT Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
RL Nature 341:405-409 (1989).
RN [3]; RE0003917.
RX PUBMED: 1983472.
RA Frohman M. A., Boyle M., Martin G. R.
RT Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm
RL Development 110:589-607 (1990).
RN [4]; RE0003918.
RX PUBMED: 1972280.
RA Rubock M. J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H.
RT A yeast artificial chromosome containing the mouse homeobox cluster Hox-2
RL Proc. Natl. Acad. Sci. USA 87:4751-4755 (1990).
RN [5]; RE0003919.
RX PUBMED: 1673098.
RA Murphy P., Hill R. E.
RT Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain
RL Development 111:67-74 (1991).
RN [6]; RE0003922.
RX PUBMED: 1682879.
RA Papalopulu N., Lovell-Badge R., Krumlauf R.
RT The expression of murine Hox-2 genes is dependent on the differentiation pathway and displays a collinear sensitivity to retinoic acid in F9 cells and Xenopus embryos
RL Nucleic Acids Res. 19:5497-5506 (1991).
RN [7]; RE0003923.
RX PUBMED: 1545869.
RA Guthrie S., Muchamore I., Kuroiwa A., Marshall H., Krumlauf R., Lumsden A.
RT Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions
RL Nature 356:157-159 (1992).
RN [8]; RE0010309.
RX PUBMED: 7600572.
RA Poepperl H., Bienz M., Studer M., Chan S.-K., Aparicio S., Brenner S., Mann R. S., Krumlauf R.
RT Segmental Expression of Hoxb-1 Is Controlled by a Highly Conserved Autoregulatory Loop Dependent upon exd/pbx
RL Cell 81:1031-1042 (1995).
RN [9]; RE0014613.
RX PUBMED: 9733765.
RA Chen J., Ruley H. E.
RT An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins
RL J. Biol. Chem. 273:24670-24675 (1998).
RN [10]; RE0014614.
RX PUBMED: 8763497.
RA Mann R. S., Chan S. K.
RT Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
RL Trends Genet. 12:258-262 (1996).
RN [11]; RE0047786.
RX PUBMED: 12487626.
RA Subramaniam N., Campion J., Rafter I., Okret S.
RT Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1.
RL Biochem. J. 370:1087-1095 (2003).
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