AC T03451
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ID T03451
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DT 16.06.2000 (created); rio.
DT 03.03.2008 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Pbx1a
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SY pre B-cell leukemia transcription factor 1a.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002136 Pbx1.
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HO Exd (Drosophila), MATa1 (yeast), ceh-20 (C. elegans).
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CL C0006; homeo; 3.1.4.4.1.1.
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SZ 430 AA; 46.6 kDa (cDNA) (calc.).
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SQ MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE
SQ AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP
SQ EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM
SQ NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF
SQ NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
SQ EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG
SQ AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG
SQ PGSVHSDTSN
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SC translated from EMBL #AF020196
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FT 33 232 
PF03792; PBX domain.
FT 37 89 
Meis-1 cooperativity domain [4].
FT 86 405 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 231 294 
PS50071; HOMEOBOX_2.
FT 233 298 
SM00389; HOX_1.
FT 234 293 
PF00046; Homeobox domain.
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SF TALE (three amino acid loop extension) homeo domain superclass [1];
SF tissue specific cooperative binding with PKNOX1 T04121 [3];
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IN T01720 HOXB1; mouse, Mus musculus.
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MX M00096 V$PBX1_01.
MX M00124 V$PBX1_02.
MX M01357 V$PBX1_04.
MX M07451 V$PBX1_10.
MX M02028 V$PBX1_Q3.
MX M00998 V$PBX_Q3.
MX M07304 V$PBX_Q5.
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BS R08497.
BS R14770.
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DR TRANSPATH: MO000027387.
DR EMBL: AF020196;
DR UniProtKB: P41778-1;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0014615.
RX PUBMED: 9710595.
RA Swift G. H., Liu Y., Rose S. D., Bischof L. J., Steelman S., Buchberg A. M., Wright C. V., MacDonald R. J.
RT An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)
RL Mol. Cell. Biol. 18:5109-5120 (1998).
RN [3]; RE0015494.
RX PUBMED: 10381567.
RA Ferretti E., Schulz H., Talarico D., Blasi F., Berthelsen J.
RT The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
RL Mech. Dev. 83:53-64 (1999).
RN [4]; RE0015495.
RX PUBMED: 9405651.
RA Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P.
RT Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
RL Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997).
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