AC T04121
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ID T04121
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DT 15.12.2000 (created); rio.
DT 05.10.2015 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Prep-1
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SY Pbx regulating protein 1; PBX/Knox1-related homeobox; PREP-1; Prep1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002133 Pknox1.
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CL C0006; homeo; 3.1.4.5.1.
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SF TALE (three amino acid loop extension) homeo domain superclass [1];
SF cooperative binding with Pbx-1a T03451, Pbx-1b T02088 and Pbx-2 T04127 [3];
SF N-terminal region (HR1 and HR2) shares homology with Meis-1 T03419 T03388 T03389 and mediates binding to Pbx-1 [3];
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EX brain,,,adult; medium; RNAse protection assay; total RNA; [3].
EX cerebellum,,,adult; medium; RNAse protection assay; total RNA; [3].
EX heart,,,adult; low; RNAse protection assay; total RNA; [3].
EX intestine,,,adult; medium; RNAse protection assay; total RNA; [3].
EX kidney (right and left),,,adult; medium; RNAse protection assay; total RNA; [3].
EX liver,,,adult; medium; RNAse protection assay; total RNA; [3].
EX lung,,,adult; medium; RNAse protection assay; total RNA; [3].
EX mouse, Mus musculus,,,Theiler Stage 15; medium; RNAse protection assay; total RNA; [3].
EX mouse, Mus musculus,,,Theiler Stage 17; medium; RNAse protection assay; total RNA; [3].
EX mouse, Mus musculus,,,Theiler Stage 21; medium; RNAse protection assay; total RNA; [3].
EX mouse, Mus musculus,,,Theiler Stage 23; medium; RNAse protection assay; total RNA; [3].
EX mouse, Mus musculus,,,Theiler Stage 25; medium; RNAse protection assay; total RNA; [3].
EX mouse, Mus musculus,,,Theiler Stage 26; medium; RNAse protection assay; total RNA; [3].
EX muscles,,,adult; low; RNAse protection assay; total RNA; [3].
EX myelencephalon,,,adult; medium; RNAse protection assay; total RNA; [3].
EX spleen,,,adult; medium; RNAse protection assay; total RNA; [3].
EX testis (right and left),,,adult; very high; RNAse protection assay; total RNA; [3].
EX thymus,,,adult; medium; RNAse protection assay; total RNA; [3].
EX thymus,,,neonate (during the first month after birth); very high; RNAse protection assay; total RNA; [3].
EX uterus,,,adult; medium; RNAse protection assay; total RNA; [3].
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FF may play a role in murine Down syndrome phenotype [2];
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MX M07304 V$PBX_Q5.
MX M01459 V$PREP1_01.
MX M07464 V$PREP1_Q3.
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BS R08497.
BS R69755.
BS R38910.
BS R38912.
BS R19539.
BS R14770.
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DR TRANSPATH: MO000028024.
DR UniProtKB: O70477;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015486.
RX PUBMED: 9479508.
RA Berthelsen J., Viggiano L., Schulz H., Ferretti E., Consalez G. G., Rocchi M., Blasi F.
RT PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C
RL Genomics 47:323-324 (1998).
RN [3]; RE0015494.
RX PUBMED: 10381567.
RA Ferretti E., Schulz H., Talarico D., Blasi F., Berthelsen J.
RT The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
RL Mech. Dev. 83:53-64 (1999).
RN [4]; RE0051982.
RX PUBMED: 10654609.
RA Ferretti E., Marshall H., Popperl H., Maconochie M., Krumlauf R., Blasi F.
RT Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins.
RL Development 127:155-166 (2000).
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