AC T03419
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ID T03419
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DT 07.06.2000 (created); rio.
DT 27.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA meis1
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SY myeloid ecotropic viral integration site 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006421 MEIS1; HGNC: Meis1.
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CL C0006; homeo; 3.1.4.2.1.
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SF TALE (three amino acid loop extension) homeo domain superclass [2];
SF expressed at high levels in leukemia cell lines, especially in those of megakaryocytic-erythroid lineage [3];
SF maps to chromosome region 2p13-p14 [3];
SF N-terminal region (HR1 and HR2) shares homology with PKNOX1 T04121 and mediates binding to Pbx-1 [4];
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CP hematopoietic tissues, appendix, liver, pancreas, brain [3]; HEL [5].
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FF might be activated by retroviral insertion during leukemogenesis like it is the case in mice [1] [3];
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IN T13762 hoxa9; human, Homo sapiens.
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MX M00420 V$MEIS1AHOXA9_01.
MX M00421 V$MEIS1BHOXA9_02.
MX M00419 V$MEIS1_01.
MX M01419 V$MEIS1_02.
MX M04027 V$MEIS1_04.
MX M07452 V$MEIS1_06.
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BS R66520.
BS R20301.
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DR TRANSPATH: MO000027355.
DR UniProtKB: O00470;
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RN [1]; RE0010659.
RX PUBMED: 7565694.
RA Moskow J. J., Bullrich F., Huebner K., Daar I. O., Buchberg A. M.
RT Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice
RL Mol. Cell. Biol. 15:5434-5443 (1995).
RN [2]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [3]; RE0014570.
RX PUBMED: 9226379.
RA Smith Jr. J. E., Bollekens J. A., Inghirami G., Takeshita K.
RT Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene
RL Genomics 43:99-103 (1997).
RN [4]; RE0015488.
RX PUBMED: 9482739.
RA Berthelsen J., Zappavigna V., Mavilio F., Blasi F.
RT Prep1, a novel functional partner of Pbx proteins
RL EMBO J. 17:1423-1433 (1998).
RN [5]; RE0030968.
RX PUBMED: 12609849.
RA Okada Y., Nagai R., Sato T., Matsuura E., Minami T., Morita I., Doi T.
RT Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.
RL Blood 101:4748-56 (2003).
RN [6]; RE0048810.
RX PUBMED: 17000644.
RA Vertegaal A. C., Andersen J. S., Ogg S. C., Hay R. T., Mann M., Lamond A. I.
RT Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics.
RL Mol. Cell. Proteomics 5:2298-2310 (2006).
RN [7]; RE0065074.
RX PUBMED: 10082572.
RA Shen W. F., Rozenfeld S., Kwong A., Kom ves L. G., Lawrence H. J., Largman C.
RT HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.
RL Mol. Cell. Biol. 19:3051-3061 (1999).
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