TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01481 XX ID T01481 XX DT 04.05.1995 (created); ewi. DT 30.09.2015 (updated); jmh. CO Copyright (C), QIAGEN. XX FA Pbx1a XX SY Pbx-1; Pbx1; pre B-cell leukemia transcription factor 1a; Prl. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002135 PBX1; HGNC: Pbx1. XX HO Exd (Drosophila), MATa1 (yeast), ceh-20 (C. elegans). XX CL C0006; homeo; XX SZ 430 AA; 46.6 kDa (cDNA) (calc.). XX SQ MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE SQ AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP SQ EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM SQ NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF SQ NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE SQ EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG SQ AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG SQ PGSVHSDTSN XX SC Swiss-Prot#P40424-1 XX FT 1 140 PKNOX1 T04122 interaction domain [15]. FT 33 232 PF03792; PBX domain. FT 86 405 PF00478; IMP dehydrogenase / GMP reductase domain. FT 119 233 blocks DNA binding [17]. FT 231 294 PS50071; HOMEOBOX_2. FT 233 430 sufficient for DNA binding [17]. FT 233 298 SM00389; HOX_1. FT 234 293 PF00046; Homeobox domain. FT 347 430 transactivation domain [11]. XX SF divergent homeo domain, most similar to yeast MATa1 [10]; SF TALE (three amino acid loop extension) homeo domain superclass [12]; SF co-factor for many, but not all homeo domain proteins [7] [8]; SF cooperative binding with Meis-1 T03388 T04129 and PKNOX1 T04122 which is disrupted in the oncoprotein E2A-Pbx1 [14] [15]; SF subunit of the UEF-3 T02839 complex [13]; SF interacts DNA independently with PKNOX1 T04122 and increases binding affinity [13] [15]; SF PKNOX1-Pbx-1 complexes are present during mouse embryogenesis [15]; SF mediates DNA dependent ternary complex with HOXB1 T01719 and PKNOX1 T04122 [15] [11]; XX CN (cell lines:) lymphoid cells, B- and T-cell lineages. EX adrenal gland (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [10]. EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [10]. EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [10]. EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [10]. EX blood,monocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [10]. EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [10]. EX brain,,,fetal; very high; Northern blot; mRNA (poly-A); [10]. EX gut,,,fetal; medium; Northern blot; mRNA (poly-A); [10]. EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [10]. EX heart,,,fetal; high; Northern blot; mRNA (poly-A); [10]. EX kidney (right and left),,,adult; none; Northern blot; mRNA (poly-A); [10]. EX kidney (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [10]. EX liver,,,fetal; medium; Northern blot; mRNA (poly-A); [10]. EX lung (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [10]. EX ovary (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [10]. EX spleen,,,fetal; medium; Northern blot; mRNA (poly-A); [10]. EX thymus,,,adult; none; Northern blot; mRNA (poly-A); [10]. EX thymus,,,fetal; medium; Northern blot; mRNA (poly-A); [10]. EX tonsil,,,adult; medium; Northern blot; mRNA (poly-A); [10]. EX uterus,,,adult; medium; Northern blot; mRNA (poly-A); [10]. XX FF in acute lymphoblastic leukemias, a t(1; FF 19)(q23; FF p13.3) translocation fuses the trans-activation domain encoded by the E2A gene with the homeobox of PBX1 [4] [1] [2]; FF the resulting chimeric protein (E2A-Pbx1) causes acute myeloid leukemia and induces enhanced proliferation as well as apoptosis probably by interfering with differentiation regulation by homeo domain factors and acting as a strong activator [3] [5] [7] [8] [9]; FF acts as cofactor of HOXB1 T01719 and cooperative transcriptional activator [11]; FF PKNOX2/Pbx-1a heterodimer (T01481/T05155) shows faster DNA-dissociation rate (binding site: R08497) than PKNOX1/Pbx-1a heterodimer (T01481/T04122) [16]; XX IN T14354 hoxa9; mouse, Mus musculus. IN T04122 PREP-1; human, Homo sapiens. IN T05155 PREP-2; human, Homo sapiens. XX MX M00096 V$PBX1_01. MX M00124 V$PBX1_02. MX M01357 V$PBX1_04. MX M07451 V$PBX1_10. MX M02028 V$PBX1_Q3. MX M00998 V$PBX_Q3. MX M07304 V$PBX_Q5. XX BS R06396. BS R06397. BS R06398. BS R06399. BS R06400. BS R06401. BS R06402. BS R06403. BS R06404. BS R06405. BS R06406. BS R06407. BS R06408. BS R06409. BS R06410. BS R06411. BS R06818. BS R06819. BS R06820. BS R06821. BS R06822. BS R06823. BS R06824. BS R06825. BS R06826. BS R06827. BS R06828. BS R06829. BS R06830. BS R06831. BS R06832. BS R06833. BS R06834. BS R06835. BS R06836. BS R06837. BS R06838. BS R06839. BS R06840. BS R06841. BS R06842. BS R06843. BS R06844. BS R06845. BS R06846. BS R06847. BS R06848. BS R06849. BS R06850. BS R06851. BS R06852. BS R06853. BS R06854. BS R06855. BS R06856. BS R06857. BS R15380. BS R14734. BS R09696. BS R09700. BS R09701. BS R14719. BS R08497. BS R09699. BS R12755. BS R04572. BS R04724. XX DR TRANSPATH: MO000025703. DR EMBL: M86546; DR UniProtKB: P40424-1; XX RN [1]; RE0000161. RX PUBMED: 1967982. RA Nourse J., Mellentin J. D., Galili N., Wilkinson J., Stanbridge E., Smith S. D., Cleary M. L. RT Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor RL Cell 60:535-545 (1990). RN [2]; RE0000671. RX PUBMED: 1672117. RA Kamps M. P., Look A. T., Baltimore D. RT The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials RL Genes Dev. 5:358-368 (1991). RN [3]; RE0003009. RX PUBMED: 7910944. RA Lu Q., Wright D. D., Kamps M. P. RT Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation RL Mol. Cell. Biol. 14:3938-3948 (1994). RN [4]; RE0004014. RX PUBMED: 1967983. RA Kamps M. P., Murre C., Sun X. H., Baltimore D. RT A new homeobox gene contributes the DNA binding domain oft the t(1; 19) translocation protein in pre-B ALL RL Cell 60:547-555 (1990). RN [5]; RE0004018. RX PUBMED: 8093327. RA Kamps M. P., Baltimore D. RT E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia causes acute myeloid leukemia in mice RL Mol. Cell. Biol. 13:351-357 (1993). RN [6]; RE0005177. RX PUBMED: 7913464. RA Kagawa N., Ogo A., Takahashi Y., Iwamatsu A., Waterman M. R. RT A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1 RL J. Biol. Chem. 269:18716-18719 (1994). RN [7]; RE0005178. RX PUBMED: 7791786. RA Lu Q., Knoepfler P. S., Scheele J., Wright D. D., Kamps M. P. RT Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. RL Mol. Cell. Biol. 15:3786-3795 (1995). RN [8]; RE0005179. RX PUBMED: 7623795. RA Phelan M. L., Rambaldi I., Featherstone M. S. RT Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif RL Mol. Cell. Biol. 15:3989-3997 (1995). RN [9]; RE0005180. RX PUBMED: 8104101. RA Dedera D. A., Waller E. K., LeBrun D. P., Sen-Majumdar A., Stevens M. E., Barsh G. S., Cleary M. L. RT Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice RL Cell 74:833-843 (1993). RN [10]; RE0005181. RX PUBMED: 1682799. RA Monica K., Saltman D., Nourse J., Galili N., Cleary M. L. RT PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 RL Mol. Cell. Biol. 11:6149-6157 (1991). RN [11]; RE0005973. RX PUBMED: 9218805. RA Rocco di G., Mavilio F., Zappavigna V. RT Functional dissection of a transcripitonally active, target-specific Hox-Pbx complex RL EMBO J. 16:3644-3654 (1997). RN [12]; RE0014544. RX PUBMED: 9336443. RA Burglin T. R. RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals RL Nucleic Acids Res. 25:4173-4180 (1997). RN [13]; RE0015488. RX PUBMED: 9482739. RA Berthelsen J., Zappavigna V., Mavilio F., Blasi F. RT Prep1, a novel functional partner of Pbx proteins RL EMBO J. 17:1423-1433 (1998). RN [14]; RE0015495. RX PUBMED: 9405651. RA Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P. RT Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 RL Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997). RN [15]; RE0015500. RX PUBMED: 9482740. RA Berthelsen J., Zappavigna V., Ferretti E., Mavilio F., Blasi F. RT The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity RL EMBO J. 17:1434-1445 (1998). RN [16]; RE0017883. RX PUBMED: 11972344. RA Fognani C., Kilstrup-Nielsen C., Berthelsen J., Ferretti E., Zappavigna V., Blasi F. RT Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors RL Nucleic Acids Res. 30:2043-2051 (2002). RN [17]; RE0024042. RX PUBMED: 9234726. RA Neuteboom S. T., Murre C. RT Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins. RL Mol. Cell. Biol. 17:4696-4706 (1997). RN [18]; RE0024570. RX PUBMED: 8183558. RA LeBrun D. P., Cleary M. L. RT Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. RL Oncogene 9:1641-1647 (1994). RN [19]; RE0065074. RX PUBMED: 10082572. RA Shen W. F., Rozenfeld S., Kwong A., Kom ves L. G., Lawrence H. J., Largman C. RT HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. RL Mol. Cell. Biol. 19:3051-3061 (1999). XX //