AC T05155
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ID T05155
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DT 26.06.2002 (created); mas.
DT 05.10.2015 (updated); sla.
CO Copyright (C), QIAGEN.
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FA PREP-2
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SY PKNOX2; PREP-2; PREP2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004511 PKNOX2; HGNC: PKNOX2.
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CL C0006; homeo; 3.1.4.5.2.
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SF TALE (three amino acid loop extension) homeo domain superclass [1] [2];
SF 52% amino acid identity between human PKNOX1 T04122 and PREP-2 T05155 in total and about 85% amino acid identity in homeo domains [2];
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CN (adult:) not detectable in liver, kidney, spleen, thymus, colon, peripheral blood leucocytes [2].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [2].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [2].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [2].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [2].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [2].
EX brain,,,adult; high; Northern blot; mRNA (poly-A); [2].
EX colon,,,adult; none; Northern blot; mRNA (poly-A); [2].
EX heart,,,adult; high; Northern blot; mRNA (poly-A); [2].
EX kidney (right and left),,,newborn; none; Northern blot; mRNA (poly-A); [2].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [2].
EX lung (right and left),,,adult; low; Northern blot; mRNA (poly-A); [2].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [2].
EX ovary (right and left),,,adult; high; Northern blot; mRNA (poly-A); [2].
EX pancreas,,,adult; low; Northern blot; mRNA (poly-A); [2].
EX placenta,,,adult; low; Northern blot; mRNA (poly-A); [2].
EX prostate gland,,,adult; low; Northern blot; mRNA (poly-A); [2].
EX small intestine,,,adult; low; Northern blot; mRNA (poly-A); [2].
EX spleen,,,adult; none; Northern blot; mRNA (poly-A); [2].
EX testis (right and left),,,adult; low; Northern blot; mRNA (poly-A); [2].
EX thymus,,,adult; none; Northern blot; mRNA (poly-A); [2].
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FF PREP-2/Pbx-1a heterodimer (T01481/T05155) shows faster DNA-dissociation rate (binding site: R08497) than PNOX1/Pbx-1a heterodimer (T01481/T04122) [2];
FF localized to cytoplasm (when recombinantly expressed in S2 and NIH3T3 cells) and requires PBX1a T01481 for nuclear translocation [2];
FF in contrast to its homolog T01481 does not enhance transcriptional activation of HOXb1/PBX1a heterodimer on HOXB1 gene G002142 autoregulatory element (compare to ) but even reduces it slightly [2];
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IN T01481 Pbx1a; human, Homo sapiens.
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MX M01411 V$PKNOX2_01.
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DR TRANSPATH: MO000032989.
DR UniProtKB: Q96KN3;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0017883.
RX PUBMED: 11972344.
RA Fognani C., Kilstrup-Nielsen C., Berthelsen J., Ferretti E., Zappavigna V., Blasi F.
RT Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors
RL Nucleic Acids Res. 30:2043-2051 (2002).
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