AC T04129
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ID T04129
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DT 20.12.2000 (created); rio.
DT 29.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA meis1-c
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SY myeloid ecotropic viral integration site 1c.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014347 Meis1.
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CL C0006; homeo.
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SZ 341 AA; 37.5 kDa (cDNA) (calc.).
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SQ MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA
SQ PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED
SQ IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKPSWNRDHDDTASTRSGGTP
SQ GPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRA
SQ WLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYN
SQ PDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
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SC sequence taken from ref. [2]
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FT 1 299 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 71 100 
HR1 domain [2].
FT 135 161 
HR2 domain (partial) [2].
FT 221 284 
PS50071; HOMEOBOX_2.
FT 223 288 
SM00389; HOX_1.
FT 224 283 
PF00046; Homeobox domain.
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SF TALE (three amino acid loop extension) homeo domain superclass [1];
SF cooperative binding with Pbx-1 T01481T02087, meis1-c is positioned 3' to Pbx-1 [2];
SF N-terminal region (HR1 and HR2) shares homology with PKNOX1 T04121 and mediates binding to Pbx-1 T01481 T02087 [2];
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MX M00420 V$MEIS1AHOXA9_01.
MX M00421 V$MEIS1BHOXA9_02.
MX M00419 V$MEIS1_01.
MX M01419 V$MEIS1_02.
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BS R09696.
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DR TRANSPATH: MO000028032.
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015495.
RX PUBMED: 9405651.
RA Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P.
RT Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
RL Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997).
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//