AC T01719
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ID T01719
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DT 08.03.1996 (created); ewi.
DT 05.12.2007 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA HOXB1
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SY homeo box B1; Hox-2.9; HOX2I; HOXB1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004684 HOXB1; HGNC: HOXB1.
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HO Lab (Drosophila) T02064.
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CL C0006; homeo; 3.1.1.1.2.
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SF cooperative binding with Pbx-1 T01481 T02087 and PKNOX1 T04122 building a ternary DNA dependent complex mediated by Pbx-1 T01481 T02087 [12] [10];
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CP expressed in erythroleukemia cells (as most other HOXB genes, contrasting to those of the HOXD cluster) [5]; Expressed in melanocyte and few melanoma cell lines like Me10538, Me665/R, Me9742/2, Me3146, FM713, FM727 and NT2/D1 [13].
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FF regulates transcription of upstream HOX genes (HOXB2-HOXB9) [9];
FF also affects expression of paralogous upstream genes [9];
FF highly sensitive to induction by retinoic acid (RA) through two RA-responsive sites of DR2-type in the 5'- and in the 3'-flanking region, both cooperating with different co-activator binding sites [3] [4] [6];
FF both RAR-responsive sites also differ in their tissue-specificity [4];
FF RA effects partly depend on the differentiation state of the cell [7];
FF induction by phytohemagglutinin (PHA) induces HOXB1 within 10 min, followed by a rapid decline [8];
FF only gene within the HOXB cluster that is found in quiescent T-cells [8];
FF acts together with cofactor Pbx-1 T01481 T02087 as transcriptional activator [10];
FF may be involved in autism [11];
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DR TRANSPATH: MO000025893.
DR UniProtKB: P14653;
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RN [1]; RE0003886.
RX PUBMED: 2576652.
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
RT Organization of human class I homeobox genes
RL Genome 31:745-756 (1989).
RN [2]; RE0003895.
RX PUBMED: 2574852.
RA Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.
RT The human HOX gene family
RL Nucleic Acids Res. 17:10385-10402 (1989).
RN [3]; RE0003909.
RX PUBMED: 7831296.
RA Ogura T., Evans R. M.
RT A retinoic acid-triggered cascade of HOXB1 gene activation
RL Proc. Natl. Acad. Sci. USA 92:387-391 (1995).
RN [4]; RE0003910.
RX PUBMED: 7831297.
RA Ogura T., Evans R. M.
RT Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation
RL Proc. Natl. Acad. Sci. USA 92:392-396 (1995).
RN [5]; RE0003920.
RX PUBMED: 1712489.
RA Magli M. C., Barba P., Celetti A., de Vita G., Cillo C., Boncinelli E.
RT Coordinate regulation of HOX genes in human hematopoietic cells
RL Proc. Natl. Acad. Sci. USA 88:6348-6352 (1991).
RN [6]; RE0003921.
RX PUBMED: 1975088.
RA Simeone A., Acampora D., Arcioni L., Andrews P. W., Boncinelli E., Mavilio F.
RT Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells
RL Nature 346:763-766 (1990).
RN [7]; RE0003924.
RX PUBMED: 1360433.
RA Safaei R., Prochazka V., Detmer K., Boncinelli E., Lawrence H. J., Largman C.
RT Modulation of HOX2 gene expression following differentiation of neural cell lines
RL Differentiation 5:39-47 (1992).
RN [8]; RE0003925.
RX PUBMED: 7911974.
RA Care A., Testa U., Bassani A., Tritarelli E., Montesoro E., Samoggia P., Cianetti L., Peschle C.
RT Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes
RL Mol. Cell. Biol. 14:4872-4877 (1994).
RN [9]; RE0003926.
RX PUBMED: 7911240.
RA Faiella A., Zappavigna V., Mavilio F., Boncinelli E.
RT Inhibition of retinoic acid-induced activation of 3' human HOXB genes by antisense oligonucleotides affects sequential activation of genes located upstream in the four HOX clusters
RL Proc. Natl. Acad. Sci. USA 91:5335-5339 (1994).
RN [10]; RE0005973.
RX PUBMED: 9218805.
RA Rocco di G., Mavilio F., Zappavigna V.
RT Functional dissection of a transcripitonally active, target-specific Hox-Pbx complex
RL EMBO J. 16:3644-3654 (1997).
RN [11]; RE0015483.
RX PUBMED: 11091361.
RA Ingram J. L., Stodgell C. J., Hyman S. L., Figlewicz D. A., Weitkamp L. R., Rodier P. M.
RT Discovery of allelic variants of HOXA1 and HOXB1: Genetic susceptibility to autism spectrum disorders
RL Teratology 62:393-405 (2000).
RN [12]; RE0015500.
RX PUBMED: 9482740.
RA Berthelsen J., Zappavigna V., Ferretti E., Mavilio F., Blasi F.
RT The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
RL EMBO J. 17:1434-1445 (1998).
RN [13]; RE0012439.
RX PUBMED: 8756643.
RA Care A., Silvani A., Meccia E., Mattia G., Stoppacciaro A., Parmiani G., Peschle C., Colombo M. P.
RT HOXB7 constitutively activates basic fibroblast growth factor in melanomas
RL Mol. Cell. Biol. 16:4842-4851 (1996).
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