AC T00377
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ID T00377
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DT 15.10.1992 (created); ewi.
DT 03.03.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA HOXA5
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SY Chox-1.3 (chick); Hox-1.3; Hoxa-5.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000525 Hoxa5.
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HO Scr (Drosophila).
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CL C0006; homeo; 3.1.1.5.1.
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SF phosphorylation [1];
SF moderate affinity to homeo domain consensus sequence (KD = 5 nM) [6];
SF a cis-regulatory region of 604 bp directs expression from cervical metamere 3 to thoracic metamere 2 (C3-T2) in the branchial spinal cord [9];
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CP (embryo 12.5 days:) CNS caudal to a boundary in the posterior myelencephalon, lung (low), dorsal parts of the mantle layer, oesophagus, trachea, stomach, posterior gut, mesonephric/metanephric kidney, testis [7].
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FF mutation causes homeotic transformations in cervical and thoracic regions [5];
FF the 7th cervical vertebra adopts thoracic-like features including the presence of a pair of ribs [5];
FF also expressed in certain kidney substructures [10] [8];
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IN T03388 meis1-a; mouse, Mus musculus.
IN T03389 meis1-b; mouse, Mus musculus.
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MX M00023 V$HOX13_01.
MX M01452 V$HOX13_02.
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BS R05447.
BS R05448.
BS R05449.
BS R05450.
BS R05451.
BS R05452.
BS R05453.
BS R05454.
BS R05455.
BS R05456.
BS R02638.
BS R04538.
BS R02635.
BS R02636.
BS R02637.
BS R01678.
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DR TRANSPATH: MO000046024.
DR UniProtKB: P09021; HXA5_MOUSE.
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RN [1]; RE0000655.
RX PUBMED: 2565857.
RA Odenwald W. F., Garbern J., Arnheiter H., Tournier-Lasserve E., Lazzarini R. A.
RT The HOX-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein
RL Genes Dev. 3:158-172 (1989).
RN [2]; RE0002766.
RX PUBMED: 2325642.
RA Hirsch M.-R., Gaugler L., Deagostini-Bazin H., Bally-Cuif L., Goridis C.
RT Identification of Positive and Negative Regulatory Elements Governing Cell-Type-Specific Expression of the Neural Cell Adhesion Molecule Gene
RL Mol. Cell. Biol. 10:1959-1968 (1990).
RN [3]; RE0003882.
RX PUBMED: 2890554.
RA Odenwald W. F., Taylor C. F., Palmer-Hill F. J., Friedrich jr V., Tani M., Lazzarini R. A.
RT Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons
RL Genes Dev. 1:482-496 (1987).
RN [4]; RE0003883.
RX PUBMED: 2901335.
RA Fibi M., Zink B., Kessel M., Colberg-Poley A. M., Labeit S., Lehrach H., Gruss P.
RT Coding sequence and expression of the homeobox gene hox 1.3
RL Development 102:349-359 (1988).
RN [5]; RE0003884.
RX PUBMED: 7901120.
RA Jeannotte L., Lemieux M., Charron J., Poirier F., Robertson E. J.
RT Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene
RL Genes Dev. 7:2085-2096 (1993).
RN [6]; RE0003885.
RX PUBMED: 7911971.
RA Pellerin I., Schnabel C., Catron K. M., Abate C.
RT Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
RL Mol. Cell. Biol. 14:4532-4545 (1994).
RN [7]; RE0003983.
RX PUBMED: 1976088.
RA Gaunt S. J., Coletta P. L., Pravtcheva D., Sharpe P. T.
RT Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network
RL Development 109:329-339 (1990).
RN [8]; RE0006757.
RX PUBMED: 2904354.
RA Gaunt S. J.
RT Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5
RL Development 103:135-144 (1988).
RN [9]; RE0014483.
RX PUBMED: 10075847.
RA Nowling T., Zhou W., Krieger K. E., Larochelle C., Nguyen-Huu M. C., Jeannotte L., Tuggle C. K.
RT Hoxa5 gene regulation: A gradient of binding activity to a brachial spinal cord element
RL Dev. Biol. 208:134-146 (1999).
RN [10]; RE0014517.
RA Davies J. A., Brandli A. W.
RT The Kidney Development Database; URL: http://www.ana.ed.ac.uk/anatomy/database/kidbase/tranfack.html
RL Internet : (1997).
RN [11]; RE0064941.
RX PUBMED: 15617687.
RA Williams T. M., Williams M. E., Innis J. W.
RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
RL Dev. Biol. 277:457-471 (2005).
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