AC T01728
XX
ID T01728
XX
DT 11.03.1996 (created); ewi.
DT 03.03.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
XX
FA HOXB4
XX
SY homeo box B4; Hox-2.6; Hoxb-4; HOXB4.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G014497 Hoxb4.
XX
HO Dfd (Drosophila).
XX
CL C0006; homeo; 3.1.1.4.2.
XX
SF dissociation constant for binding to a homeo domain consensus site: KD = 1 nM [2];
SF unique DNA-binding specificity with regard to nucleotides that flank the core motif [2];
XX
FF although being part of the 3' ->5' expression waves of homeobox gene clusters, the isolated regulatory region of the HOXB4 gene is still functional [6];
FF 2 spatially specific enhancers govern the expression pattern, one of them is responsible for expression in the neural tube [6];
XX
IN T03388 meis1-a; mouse, Mus musculus.
IN T03389 meis1-b; mouse, Mus musculus.
XX
MX M01424 V$HOXB4_01.
XX
DR TRANSPATH: MO000046052.
DR UniProtKB: P10284; HXB4_MOUSE.
XX
RN [1]; RE0003884.
RX PUBMED: 7901120.
RA Jeannotte L., Lemieux M., Charron J., Poirier F., Robertson E. J.
RT Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene
RL Genes Dev. 7:2085-2096 (1993).
RN [2]; RE0003885.
RX PUBMED: 7911971.
RA Pellerin I., Schnabel C., Catron K. M., Abate C.
RT Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
RL Mol. Cell. Biol. 14:4532-4545 (1994).
RN [3]; RE0003937.
RX PUBMED: 2463210.
RA Graham A., Papalopulu N., Lorimer J., McVey J. H., Tuddenham E. G. D., Krumlauf R.
RT Characterization of murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene
RL Genes Dev. 2:1424-1438 (1988).
RN [4]; RE0003938.
RX PUBMED: 1446073.
RA Kristensen T., Lopez R., Prydz H.
RT An estimate of the sequencing error frequency in the DNA sequence databases
RL DNA Seq. 2:343-346 (1992).
RN [5]; RE0003939.
RX PUBMED: 2906328.
RA Do M. S., Lonai P.
RT Gene organization of murine homeobox-containing gene clusters
RL Genomics 3:195-200 (1988).
RN [6]; RE0003941.
RX PUBMED: 1682218.
RA Whiting J., Marshall H., Cook M., Krumlauf R., Rigby P. W. J., Stott D., Allemann R. K.
RT Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression
RL Genes Dev. 5:2048-2059 (1991).
RN [7]; RE0064941.
RX PUBMED: 15617687.
RA Williams T. M., Williams M. E., Innis J. W.
RT Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
RL Dev. Biol. 277:457-471 (2005).
XX
//